Qing Li
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View article: Revisiting noncoding RNAs: emerging coding functions and their impact on skeletal muscle development
Revisiting noncoding RNAs: emerging coding functions and their impact on skeletal muscle development Open
Accumulating evidence has revealed noncoding RNAs (ncRNAs) as versatile regulators in skeletal muscle development, extending beyond their canonical roles as nontranslating transcripts. Recent advancements in proteomics and translatomics ha…
View article: Endoscopic resection in the treatment of intramural esophageal cysts: A retrospective analysis of 67 cases
Endoscopic resection in the treatment of intramural esophageal cysts: A retrospective analysis of 67 cases Open
Background and study aims: Intramural esophageal cysts (ECs) are rare congenital malformations. This study aimed to investigate the clinical characteristics of intramural ECs and evaluate the safety and efficacy of endoscopic resection. Pa…
View article: Multi-omics analysis of key lipid metabolism-related genes involved in the anti-hepatocellular carcinoma effect of dihydroartemisinin
Multi-omics analysis of key lipid metabolism-related genes involved in the anti-hepatocellular carcinoma effect of dihydroartemisinin Open
Based on analyses of public databases and computational predictions, DHA may exert anti-HCC effects by regulating the p53 signaling pathway, cell cycle progression, and the LMRGs. However, these potential regulatory mechanisms require furt…
View article: Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries
Diversity, transfer potential, and transcriptional activity of virus‐carried antibiotic resistance genes in global estuaries Open
Estuaries, the transition zones between terrestrial and marine ecosystems, are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been considered as reservoirs and vectors o…
View article: Two Birds with One Stone: One-Pot Conversion of Waste Biomass into N-Doped Porous Biochar for Efficient Formaldehyde Adsorption
Two Birds with One Stone: One-Pot Conversion of Waste Biomass into N-Doped Porous Biochar for Efficient Formaldehyde Adsorption Open
Converting agricultural solid waste into porous biochar for HCHO adsorption is considered as a “two birds with one stone” strategy, which can achieve the environmental goal of “treating waste with waste”. Unfortunately, the HCHO adsorption…
View article: The effect of intraoperative hypotension on postoperative delirium: a meta-analysis and systematic review
The effect of intraoperative hypotension on postoperative delirium: a meta-analysis and systematic review Open
Background Postoperative delirium (POD) is a common complication linked to poor outcomes, yet its relationship with intraoperative hypotension (IOH) remains unclear. The objective of this study was to clarify the association between intrao…
View article: Configurational pathways to pediatric e-bike injury severity: an fsQCA study of global evidence
Configurational pathways to pediatric e-bike injury severity: an fsQCA study of global evidence Open
Background E-bike use among children and adolescents has surged worldwide, raising concerns about injury severity and safety management. While prior research has identified multiple risk factors, the complex interplay among study and conte…
View article: Precision medicine in Crohn’s disease: Navigating the path from biomarker discovery to clinical implementation
Precision medicine in Crohn’s disease: Navigating the path from biomarker discovery to clinical implementation Open
Crohn’s disease (CD) is a highly heterogeneous inflammatory bowel disorder. Despite an expanding therapeutic arsenal, treatment selection remains largely empirical, often leading to delayed effective control and suboptimal outcomes. Precis…
View article: Clinical Validation of DNA Methylation Detection in Cervical Exfoliated Cells for Endometrial Cancer in Women with Suspected Lesions
Clinical Validation of DNA Methylation Detection in Cervical Exfoliated Cells for Endometrial Cancer in Women with Suspected Lesions Open
Background/Objectives: Currently, no non-invasive detection method for endometrial cancer (EC) is recommended in clinical practice worldwide. This study aimed to evaluate the clinical value of detecting DNA methylation of CDO1 and CELF4 (C…
View article: Advances and challenges in point‐of‐care testing for pathogenic bacteria in battlefield injuries
Advances and challenges in point‐of‐care testing for pathogenic bacteria in battlefield injuries Open
Infections are a leading contributor to delayed mortality in patients with combat‐related trauma. Thus, the real‐time, accurate, and rapid detection of invasive pathogens is essential for optimizing wound management and accelerating recove…
View article: Distinct antidepressant therapies act on a common brain network
Distinct antidepressant therapies act on a common brain network Open
Depression disorder is a global health crisis, due to its high prevalence. Yet clinical treatments are inadequate. Uncovering the neural correlates of depression remission is a vital step toward developing effective therapies. Using a meth…
View article: KRAS-ERK signaling drives metastasis in colorectal cancer via phosphorylation-dependent activation of the ZBTB20-TGFBR2 axis
KRAS-ERK signaling drives metastasis in colorectal cancer via phosphorylation-dependent activation of the ZBTB20-TGFBR2 axis Open
Background Metastatic colorectal cancer (CRC) harboring KRAS mutations presents a major therapeutic challenge due to its aggressive nature, poor prognosis, and resistance to EGFR-targeted therapies. This study aimed to identify novel drive…
View article: Decoding neurotransmitter and genetic contributions to abnormal neuronal signal variability in Anti‑N‑Methyl‑D‑Aspartate receptor encephalitis: Implications for targeted therapies
Decoding neurotransmitter and genetic contributions to abnormal neuronal signal variability in Anti‑N‑Methyl‑D‑Aspartate receptor encephalitis: Implications for targeted therapies Open
This study identifies a transcriptional signature that is spatially associated with CVBOLD/FC abnormalities and neurotransmitter distributions in anti-NMDAR encephalitis, thereby generating hypotheses about molecular targets that may be re…
View article: Spatial heterogeneity of viral communities across the gastrointestinal tracts of ruminants
Spatial heterogeneity of viral communities across the gastrointestinal tracts of ruminants Open
These findings suggest that the GIT viral communities exhibit spatial heterogeneity with distinct virus-host interactions, and offer new perspectives on maintenance of complex ecological and nutritional functions in ruminant GIT.
View article: Critical transition of urban ozone formation regime in the North China Plain
Critical transition of urban ozone formation regime in the North China Plain Open
Over the past decade, China has achieved remarkable progress in mitigating the aerosol pollution. However, ozone (O3) pollution still shows a worsening trend, implying that China’s control measures may have been less effective in tackling …