Jianwei Sun
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View article: Copper-Catalyzed Enantioselective Intra- and Intermolecular Desymmetrization of Azetidiniums by Carbon Nucleophiles
Copper-Catalyzed Enantioselective Intra- and Intermolecular Desymmetrization of Azetidiniums by Carbon Nucleophiles Open
Disclosed here is a transition-metal-catalyzed enantioselective ring-opening of azetidiniums. It also represents the first demonstration of catalytic enantioselective intramolecular desymmetrization of prochiral azetidiniums. With a cheap …
View article: Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer
Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer Open
Biomacromolecules such as DNA, proteins, and polysaccharides possess unique helical structures that are closely related to their biological functions involving recognition, catalysis, replication, and genetic information storage. From a bi…
View article: Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer
Fluorescence Visualization of Helix Inversion in Biomimic Polymeric Foldamer Open
Biomacromolecules such as DNA, proteins, and polysaccharides possess unique helical structures that are closely related to their biological functions involving recognition, catalysis, replication, and genetic information storage. From a bi…
View article: Catalytic Enantioselective Perezone-Type [5 + 2] Cycloaddition
Catalytic Enantioselective Perezone-Type [5 + 2] Cycloaddition Open
Here we report the first catalytic enantioselective Perezone-type [5 + 2] cycloaddition, enabling convenient access to a variety of bicyclo[3.2.1]octanes and other complex carbocycles from readily available quinone ketals and alkenes. Enab…
View article: Design, Synthesis, and Application of a Type of Chiral Spirocyclic Naphthylamines
Design, Synthesis, and Application of a Type of Chiral Spirocyclic Naphthylamines Open
A family of new spirocyclic chiral mono- and diamine structures has been designed together with their de novo asymmetric synthesis, featuring a short sequence from simple substrates. This study complements the previous limited exploration …
View article: Constructing visible light-activatable luminogens with multiresponsive functions via a site-blocking design
Constructing visible light-activatable luminogens with multiresponsive functions via a site-blocking design Open
Photoswitches exhibiting large structural variation, visible light responsiveness, and multifunctionality are important for both chemistry and bionics research. However, beyond the limited variety of functional motifs, removing high-energy…
View article: Strategic Design of Aptamer‐Guided Aggregation‐Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer
Strategic Design of Aptamer‐Guided Aggregation‐Induced Emission Nanoparticles for Targeted Photodynamic Therapy in Breast Cancer Open
Breast cancer (BC), characterized by its heterogeneity and diverse subtypes, necessitates personalized treatment strategies. This study presents MF3Ec‐TBPP nanoparticles (NPs) as a promising approach, integrating an aggregation‐induced emi…
View article: Ruthenium-Catalyzed Intermolecular [2 + 2] Cycloaddition of Unactivated Allenes and Alkynes with Unusual Regioselectivity
Ruthenium-Catalyzed Intermolecular [2 + 2] Cycloaddition of Unactivated Allenes and Alkynes with Unusual Regioselectivity Open
Described here is an efficient protocol for intermolecular [2 + 2] cycloaddition of unactivated and unsymmetrical allenes and alkynes with unusual regioselectivity, counterintuitively favoring the most hindered isomer. CpRu(MeCN)3PF6 serve…
View article: Enantioselective Synthesis of α-Oxygenated Ketones via Organocatalytic Formal O–H Bond Insertion of Sulfonium Ylides
Enantioselective Synthesis of α-Oxygenated Ketones via Organocatalytic Formal O–H Bond Insertion of Sulfonium Ylides Open
Described here is an example of organocatalytic enantioselective formal O-H bond insertion of α-carbonyl sulfur ylides, providing efficient access to highly enantioenriched ketones bearing a tertiary α-oxygenated stereocenter. This metal-f…
View article: FSCN1-mediated hepatic gluconeogenesis is indispensable for neonatal mice survivalFSCN1 regulates gluconeogenesis and neonatal survival
FSCN1-mediated hepatic gluconeogenesis is indispensable for neonatal mice survivalFSCN1 regulates gluconeogenesis and neonatal survival Open
Actin-bundling protein Fascin1 (FSCN1) is encoded by the Fscn1 gene and is crucial for cytoskeletal remodeling and cellular migration. Although a previous study linked Fscn1 deficiency to neonatal lethality in mice, the underlying metaboli…
View article: A universal solution‐phase strategy for bright lanthanide(III) emission: aggregation‐induced emission via electronic–vibrational decoupling
A universal solution‐phase strategy for bright lanthanide(III) emission: aggregation‐induced emission via electronic–vibrational decoupling Open
Lanthanide ions (Ln³⁺) in solution typically suffer from severe luminescence quenching due to vibrational coupling with solvent molecules. Herein, we report the universal occurrence of aggregation-induced emission (AIE) via electronic–vibr…
View article: A chameleon AIEgen exhibiting six distinct yet tunable thermal and photoswitchable states
A chameleon AIEgen exhibiting six distinct yet tunable thermal and photoswitchable states Open
Seeking methods to realize multiple fluorescence changes in a single luminogenic system is of great importance for both chemistry and bionics research. Due to the lack of effective strategies and functional motifs, luminogens with multiple…
View article: Building bridges through dynamic coupling for organic phosphorescence
Building bridges through dynamic coupling for organic phosphorescence Open
Achieving long-lived room temperature phosphorescence (RTP) in organic materials has garnered significant attention in the field of optoelectronics. Although many host−guest systems with versatile performances have been developed, their ph…
View article: Enantioselective Synthesis of 2,3-Disubstituted Azetidines via Copper-Catalyzed Boryl Allylation of Azetines
Enantioselective Synthesis of 2,3-Disubstituted Azetidines via Copper-Catalyzed Boryl Allylation of Azetines Open
Disclosed here is a highly enantioselective difunctionalization of azetines for convenient access to chiral 2,3-disubstituted azetidines, a family of important scaffolds previously lacking general access. With Cu/bisphosphine as a catalyst…
View article: Manipulation of Intramolecular and Intermolecular Noncovalent Conformational Locked Network via Side-Chain Isomerization for Constructing Planar NIR-II Phototheranostic Aggregates
Manipulation of Intramolecular and Intermolecular Noncovalent Conformational Locked Network via Side-Chain Isomerization for Constructing Planar NIR-II Phototheranostic Aggregates Open
The transition from molecular-scale intramolecular non-covalent conformational locking (NoCL) to hierarchically organized intra- and intermolecular NoCL in aggregates presents transformative potential for engineering photo-theranostic aggr…
View article: United we stand: Perovskite quantum dot/AIEgen hybrids with high optical stability and efficiency
United we stand: Perovskite quantum dot/AIEgen hybrids with high optical stability and efficiency Open
Perovskite quantum dots and aggregation-induced-emission luminogens (AIEgens) are both widely investigated luminescent materials, yet they generally suffer from poor photostability. In this study, we fabricated a nanocomposite exhibiting e…
View article: Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H <sub>3</sub> PO <sub>4</sub> in Aqueous Media
Electrochemical Enantioselective Oxidation of Indoles via Chiral Phosphoric Acid Catalysis in Cooperation with H <sub>3</sub> PO <sub>4</sub> in Aqueous Media Open
Disclosed here is the first catalytic enantioselective electrochemical oxidative rearrangement of indoles for the efficient synthesis of highly enantioenriched spirooxindoles. The in‐situ generated HBr from substrate oxidation, known to be…
View article: Photoinduced Copper-Catalyzed Enantioselective Allylic C(<i>sp</i><sup>3</sup>)–H Oxygenation of Acyclic Terminal Olefins Enabled by SphenBOX
Photoinduced Copper-Catalyzed Enantioselective Allylic C(<i>sp</i><sup>3</sup>)–H Oxygenation of Acyclic Terminal Olefins Enabled by SphenBOX Open
Although the copper-catalyzed allylic C(sp3)-H oxygenation (Kharasch-Sosnovsky reaction) is a powerful transformation known for over a half century, its enantioselective version has been developed with drawbacks. High enantioselectivity wa…
View article: Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone
Rapid Access to an Enantioenriched Spiro Bisindole Directly from Indole and Acetone Open
Disclosed here is a “one‐pot self‐assembly” strategy for the enantioselective synthesis of a spiro bisindole molecule directly from indole and acetone. This convenient synthesis contrasts drastically to the typical long sequence required f…
View article: Recent Advances in Catalytic Asymmetric Synthesis of Chiral Sulfinyl Compounds
Recent Advances in Catalytic Asymmetric Synthesis of Chiral Sulfinyl Compounds Open
Chiral sulfinyl architectures have emerged as one of most important structural motifs in modern drug and agrochemical discovery due to their unique physicochemical and pharmacokinetic properties. They are also recognized as versatile platf…
View article: Effect of combined treatment with Sodium valproate and methylprednisolone onneurological recovery after experimental spinal cord injury
Effect of combined treatment with Sodium valproate and methylprednisolone onneurological recovery after experimental spinal cord injury Open
The present study aimed to investigate the effect of Sodium valproate (VAP) combined with methylprednisolone (MP) on spinal cord injury (SCI), and its underlying mechanism. Following the establishment of the SCI model using SD mice, VPA tr…
View article: Synthesis of γ-Lactams by Intermolecular (3 + 2) Annulation of Siloxy Alkynes and 3-Aminooxetanes
Synthesis of γ-Lactams by Intermolecular (3 + 2) Annulation of Siloxy Alkynes and 3-Aminooxetanes Open
A silver-catalyzed intermolecular (3 + 2) annulation of siloxy alkynes and 3-aminooxetanes has been developed. This process provides mild and convenient access to useful γ-butyrolactams with high regio- and stereoselectivity. Mechanistical…
View article: Fluorescence tracking of inter- and intramolecular motion in zwitterionic aggregate
Fluorescence tracking of inter- and intramolecular motion in zwitterionic aggregate Open
Ionic aggregates are among the most common forms of matter, yet the investigation of their molecular motion is often constrained by the instability of isolated anions and cations, as well as the lack of real-time monitoring techniques. Thi…
View article: Iridium‐Catalyzed Asymmetric Allenylic Substitution via Kinetic Resolution Enabled by New Monodentate Ligands
Iridium‐Catalyzed Asymmetric Allenylic Substitution via Kinetic Resolution Enabled by New Monodentate Ligands Open
Iridium‐catalyzed asymmetric allenylic substitution represents a useful method for the construction of allenes bearing an allenylic central chirality, but current success has uniformly relied on only one specific chiral bidentate ligand. H…
View article: Iridium‐Catalyzed Asymmetric Allenylic Substitution via Kinetic Resolution Enabled by New Monodentate Ligands
Iridium‐Catalyzed Asymmetric Allenylic Substitution via Kinetic Resolution Enabled by New Monodentate Ligands Open
Iridium‐catalyzed asymmetric allenylic substitution represents a useful method for the construction of allenes bearing an allenylic central chirality, but current success has uniformly relied on only one specific chiral bidentate ligand. H…
View article: Hot‐Exciton‐Involved Dual‐Channel Stepwise Energy Transfer Enabling Efficient and Stable Blue OLEDs with Narrow Emission and High Luminance
Hot‐Exciton‐Involved Dual‐Channel Stepwise Energy Transfer Enabling Efficient and Stable Blue OLEDs with Narrow Emission and High Luminance Open
Marching toward next‐generation ultrahigh‐definition and high‐resolution displays, the development of high‐performance blue organic light‐emitting diodes (OLEDs) with narrow emission and high luminance is essential and requires conceptual …
View article: Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy
Facile Access to Piezoelectric Polyamides by Polyamidation of Carboxylic Acids and Ynamides for Potent Tumor Immunotherapy Open
Polyamides are a fascinating group of piezoelectric materials that are largely synthesized by the polycondesation of dicarboxylic acids with diamines or the ring‐opening polymerization of special lactams. However, developing a green polyme…