Penh Sun Ly
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View article: High Performance of Systematic Combined Urine Liboarabinomannan Test and Sputum Xpert MTB/RIF for Tuberculosis Screening in Severely Immunosuppressed Ambulatory Adults With Human Immunodeficiency Virus
High Performance of Systematic Combined Urine Liboarabinomannan Test and Sputum Xpert MTB/RIF for Tuberculosis Screening in Severely Immunosuppressed Ambulatory Adults With Human Immunodeficiency Virus Open
Background In people with human immunodeficiency virus (PWH), the World Health Organization–recommended tuberculosis (TB) 4-symptom screen (W4SS) targeting those who need molecular rapid testing may be suboptimal. We assessed the performan…
View article: Virological failure and treatment switch after ART initiation among people living with HIV with and without routine viral load monitoring in Asia
Virological failure and treatment switch after ART initiation among people living with HIV with and without routine viral load monitoring in Asia Open
Introduction Viral load (VL) testing is still challenging to monitor treatment responses of antiretroviral therapy (ART) for HIV treatment programme in Asia. We assessed the association between routine VL testing and virological failure (V…
View article: Factors associated with high alanine aminotransferase (ALT) and cirrhosis in people living with HIV on combination antiretroviral treatment (cART) in the Asia‐Pacific
Factors associated with high alanine aminotransferase (ALT) and cirrhosis in people living with HIV on combination antiretroviral treatment (cART) in the Asia‐Pacific Open
Liver disease is a growing burden among people living with HIV (PLHIV) in resource‐limited settings. As an indicator of liver disease, risk factors of high alanine aminotransferase (ALT) and cirrhosis were assessed among PLHIV in the TREAT…
View article: <scp>BMI</scp> as a predictor of high fasting blood glucose among people living with <scp>HIV</scp> in the Asia‐Pacific region
<span>BMI</span> as a predictor of high fasting blood glucose among people living with <span>HIV</span> in the Asia‐Pacific region Open
Background Non‐Asian body mass index (BMI) classifications are commonly used as a risk factor for high fasting blood glucose (FBG). We investigated the incidence and factors associated with high FBG among people living with HIV in the Asia…
View article: A Cross-Sectional Assessment of HIV Self-Testing Preferences and Uptake Among Key Populations in Phnom Penh, Cambodia
A Cross-Sectional Assessment of HIV Self-Testing Preferences and Uptake Among Key Populations in Phnom Penh, Cambodia Open
Uptake of HIVST was high, and most participants preferred oral-fluid over finger-prick-based testing. Many individuals (72%) who had never previously accessed HIV testing services participated in HIVST, with high rates of reactivity.
View article: Patterns and prognosis of holding regimens for people living with HIV in Asian countries
Patterns and prognosis of holding regimens for people living with HIV in Asian countries Open
The use of holding regimens for people living with HIV (PLWH) without effective antiretroviral options can have effects on outcomes and future treatment options. We aimed to investigate the use of holding regimens for PLWH in Asian countri…
View article: Weight changes, metabolic syndrome and all‐cause mortality among Asian adults living with HIV
Weight changes, metabolic syndrome and all‐cause mortality among Asian adults living with HIV Open
Objectives We investigated weight changes following antiretroviral therapy (ART) initiation, the development of metabolic syndrome (MetS) and its association with all‐cause mortality among Asian adults living with HIV. Methods Participants…
View article: Community-based model for the delivery of antiretroviral therapy in Cambodia: a quasi-experimental study protocol
Community-based model for the delivery of antiretroviral therapy in Cambodia: a quasi-experimental study protocol Open
BackgroundMulti-month dispensing (MMD) is the mainstay mechanism for clinically stable people living with HIV in Cambodia to refill antiretroviral therapy (ART) every three to six months. However, less frequent ART dispensing through the c…
View article: Validation of the D:A:D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific
Validation of the D:A:D Chronic Kidney Disease Risk Score Model Among People Living With HIV in the Asia-Pacific Open
Background: We validated the Data collection on Adverse events of anti-HIV Drugs (D:A:D) full-risk and short-risk score models for chronic kidney disease (CKD) in the Asian HIV cohorts. Settings: A validation study among people living with…
View article: Impact of low‐level viraemia on virological failure among Asian children with perinatally acquired HIV on first‐line combination antiretroviral treatment: a multicentre, retrospective cohort study
Impact of low‐level viraemia on virological failure among Asian children with perinatally acquired HIV on first‐line combination antiretroviral treatment: a multicentre, retrospective cohort study Open
Introduction The clinical relevance of low‐level viraemia (LLV) and virological outcomes among children living with HIV (CLHIV) remains controversial. This study aimed to determine the impact of LLV on virological failure (VF) among Asian …
View article: Identification, Management, and Outcomes of Combination Antiretroviral Treatment Failure in Adolescents With Perinatal Human Immunodeficiency Virus Infection in Asia
Identification, Management, and Outcomes of Combination Antiretroviral Treatment Failure in Adolescents With Perinatal Human Immunodeficiency Virus Infection in Asia Open
Background Combination antiretroviral therapy (cART) failure is a major threat to human immunodeficiency virus (HIV) programs, with implications for individual- and population-level outcomes. Adolescents with perinatally acquired HIV infec…
View article: Determining standardized causes of death of infants, children, and adolescents living with HIV in Asia
Determining standardized causes of death of infants, children, and adolescents living with HIV in Asia Open
Objective: To implement a standardized cause of death reporting and review process to systematically disaggregate causes of HIV-related deaths in a cohort of Asian children and adolescents. Design: Death-related data were retrospectively a…
View article: Atherosclerotic cardiovascular disease screening and management protocols among adult HIV clinics in Asia
Atherosclerotic cardiovascular disease screening and management protocols among adult HIV clinics in Asia Open
The consistent availability of clinical screening, diagnostic testing and procedures and the availability of ASCVD medications in the Asian LMIC clinics surveyed are strengths that should be leveraged to improve the implementation of cardi…
View article: Status of HIV Case-Based Surveillance Implementation — 39 U.S. PEPFAR-Supported Countries, May–July 2019
Status of HIV Case-Based Surveillance Implementation — 39 U.S. PEPFAR-Supported Countries, May–July 2019 Open
Human immunodeficiency virus (HIV) case-based surveillance (CBS) systematically and continuously collects available demographic and health event data (sentinel events*) about persons with HIV infection from diagnosis and, if available, thr…
View article: Dual Analysis of Loss to Follow-up for Perinatally HIV-Infected Adolescents Receiving Combination Antiretroviral Therapy in Asia
Dual Analysis of Loss to Follow-up for Perinatally HIV-Infected Adolescents Receiving Combination Antiretroviral Therapy in Asia Open
Background: Perinatally HIV-infected adolescents (PHIVA) are an expanding population vulnerable to loss to follow-up (LTFU). Understanding the epidemiology and factors for LTFU is complicated by varying LTFU definitions. Setting: Asian reg…
View article: Treatment Modification after Second-Line Failure among People Living with HIV in Asia-Pacific
Treatment Modification after Second-Line Failure among People Living with HIV in Asia-Pacific Open
Background The World Health Organization recommends continuation with the failing second-line regimen if third-line option is not available. We investigated treatment outcomes among people living with HIV in Asia who continued with failing…
View article: Access to prevention of mother‐to‐child transmission of <scp>HIV</scp> along <scp>HIV</scp> services cascade through integrated active case management in 15 operational districts in Cambodia
Access to prevention of mother‐to‐child transmission of <span>HIV</span> along <span>HIV</span> services cascade through integrated active case management in 15 operational districts in Cambodia Open
Introduction Following the introduction of option B+ in 2013, and with the perspective of eliminating mother‐to‐child transmission of HIV by 2025, Cambodia has implemented an integrated active case management (IACM) approach since 2014 to …
View article: Increased Risk of Executive Function and Emotional Behavioral Problems Among Virologically Well-Controlled Perinatally HIV-Infected Adolescents in Thailand and Cambodia
Increased Risk of Executive Function and Emotional Behavioral Problems Among Virologically Well-Controlled Perinatally HIV-Infected Adolescents in Thailand and Cambodia Open
Background: Large numbers of perinatally HIV-infected (PHIV) children are aging into adolescence. We examined cognitive and behavioral outcomes in a longitudinal cohort of Asian youth. Methods: We followed up 231 PHIV, 125 perinatally HIV-…
View article: Impact of the frequency of plasma viral load monitoring on treatment outcomes among children with perinatally acquired <scp>HIV</scp>
Impact of the frequency of plasma viral load monitoring on treatment outcomes among children with perinatally acquired <span>HIV</span> Open
Introduction Recommendations on the optimal frequency of plasma viral load ( pVL ) monitoring in children living with HIV ( CLWH ) who are stable on combination antiretroviral therapy ( cART ) are inconsistent. This study aimed to determin…
View article: Emotional and behavioral resilience among children with perinatally acquired HIV in Thailand and Cambodia
Emotional and behavioral resilience among children with perinatally acquired HIV in Thailand and Cambodia Open
Despite biopsychosocial risks, resilience is observed among PHIV and PHEU children. Further study is needed to understand mechanisms underlying associated factors and intervention priorities.
View article: Cotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIV
Cotrimoxazole prophylaxis decreases tuberculosis risk among Asian patients with HIV Open
Introduction Cotrimoxazole ( CTX ) is recommended as prophylaxis against Pneumocystis jiroveci pneumonia, malaria and other serious bacterial infections in HIV ‐infected patients. Despite its in vitro activity against Mycobacterium tubercu…
View article: Brief Report: Malignancies in Adults Living With HIV in Asia
Brief Report: Malignancies in Adults Living With HIV in Asia Open
Background: Hematological malignancies have continued to be highly prevalent among people living with HIV (PLHIV). This study assessed the occurrence of, risk factors for, and outcomes of hematological and nonhematological malignancies in …
View article: Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia
Changes in renal function with long‐term exposure to antiretroviral therapy in HIV‐infected adults in Asia Open
Purpose Renal disease is common among people living with human immunodeficiency virus (HIV). However, there is limited information on the incidence and risk factors associated with renal dysfunction among this population in Asia. Methods W…
View article: Characteristics, mortality and outcomes at transition for adolescents with perinatal HIV infection in Asia
Characteristics, mortality and outcomes at transition for adolescents with perinatal HIV infection in Asia Open
Delayed HIV diagnosis and cART initiation resulted in considerable morbidity and poor immune status by adolescent entry. Durable first-line cART regimens to optimize disease control are key to minimizing mortality. Early cART initiation pr…
View article: Durability of Antiretroviral Therapy Regimens and Determinants for Change in HIV-1-Infected Patients in the TREAT Asia HIV Observational Database (TAHOD-LITE)
Durability of Antiretroviral Therapy Regimens and Determinants for Change in HIV-1-Infected Patients in the TREAT Asia HIV Observational Database (TAHOD-LITE) Open
Background The durability of first-line regimen is important to achieve long-term treatment success for the management of HIV infection. Our analysis describes the duration of sequential ART regimens and identifies the determinants leading…