Zhenjun Sun
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View article: CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma
CRISPR screens identify the ATPase VCP as a druggable therapeutic vulnerability in cholangiocarcinoma Open
Cholangiocarcinoma (CCA) remains a lethal malignancy with limited therapeutic options. Through genome-wide CRISPR-Cas9 screening, we identified the adenosine triphosphatase (ATPase) valosin-containing protein (VCP) as a critical dependency…
View article: SPICE: Detecting Pepper Adulteration Using Impedance Sensors and Machine Learning Techniques
SPICE: Detecting Pepper Adulteration Using Impedance Sensors and Machine Learning Techniques Open
Food adulteration in commodities such as pepper poses significant economic and public health risks, necessitating robust detection technologies. This study presents an approach combining electrical impedance spectroscopy (EIS) and advanced…
View article: Optimizing Antibiotic Prophylaxis for Type III Open Fractures in China: A Cost- Effectiveness Analysis
Optimizing Antibiotic Prophylaxis for Type III Open Fractures in China: A Cost- Effectiveness Analysis Open
Background Surgical site infections (SSI) remain a significant concern following Type III open fractures. Recent studies have suggested that narrow-spectrum antibiotics like cefazolin (CEZ) may offer comparable efficacy to broader-spectrum…
View article: Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury
Bioinformatics analysis combined with experimental validation reveals the novel mechanisms of multi-targets of dapagliflozin attenuating diabetic liver injury Open
Objective Diabetic liver injury, a chronic complication of diabetes mellitus (DM), has been extensively documented. Dapagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has shown significant therapeutic benefits in clinical …
View article: The structure and breakup mechanism of the South China Sea
The structure and breakup mechanism of the South China Sea Open
As one of the largest marginal seas in the Western Pacific, the structure and evolution of the South China Sea will provide important reference to the marginal sea research. In order to decode the continent-ocean transition and seafloor sp…
View article: Pathogenic germline variants in Chinese pancreatic adenocarcinoma patients
Pathogenic germline variants in Chinese pancreatic adenocarcinoma patients Open
Putting pancreatic adenocarcinoma (PAAD) screening into perspective for high-risk individuals could significantly reduce cancer morbidity and mortality. Previous studies have profiled somatic mutations in PAAD. In contrast, the prevalence …
View article: Ellagic Acid Protects Against Acute Stress‐Induced Kidney Damage in Rats by Regulating the SIRT1/Nrf2 Signaling Pathway
Ellagic Acid Protects Against Acute Stress‐Induced Kidney Damage in Rats by Regulating the SIRT1/Nrf2 Signaling Pathway Open
Ellagic acid displays multiple biological and pharmacological effects. Here, we explore its protective role against acute stress (AS)–induced kidney damage. We established the AS model through excessive swimming (15 min) and restraint stre…
View article: De novo assembly of a chromosome-level genome of naked carp (Gymnocypris przewalskii) reveals geographic isolation of Schizothoracine fishes in Qinghai-tibet plateau lift
De novo assembly of a chromosome-level genome of naked carp (Gymnocypris przewalskii) reveals geographic isolation of Schizothoracine fishes in Qinghai-tibet plateau lift Open
In this study, we present a de novo genome assembly of Gymnocypris przewalski using long‐read PacBio sequencing technology with Genome-wide high throughput chromosome conformation capture correction. The assembly resulted in a high sequenc…
View article: Molecular mechanisms behind global distribution of earthworm revealed by the genome
Molecular mechanisms behind global distribution of earthworm revealed by the genome Open
Earthworms (Annelida: Crassiclitellata), are widely distributed around the world due to their great adaptability. However, lack of a high-quality genome sequence prevents gaining the many insights into physiology, phylogeny, and genome evo…
View article: Mechanisms of earthworms to alleviate continuous cropping obstacles through regulating soil microecology
Mechanisms of earthworms to alleviate continuous cropping obstacles through regulating soil microecology Open
Obstacles to continuous cropping seriously affect crop yield and also lead to a series of microecological imbalance problems, such as the decline of soil biodiversity, the decrease of beneficial microbes, and the increase of pathogens.The …