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Hypoxia-Exosome Mesenchymal Stem Cells Therapy Reduces Interleukin-6 Levels and CD86 Expression Open
Background: UVB exposure activates type 1 macrophages (CD86) and increases IL-6, both contributing to collagen loss. exosome hypoxia mesenchymal stem cells (EH-MSC) has anti-inflammatory properties, suggesting its potential role in modulat…
Exosome Therapy from Hypoxia-treated Mesenchymal Stem Cells Reduces TNF-α and Increases VEGF Levels in Fluconazole-Induced Alopecia Model Open
Background: Alopecia is a condition with partial or complete hair loss, leading to psychological distress. Current treatments, such as minoxidil and finasteride, have limited efficacyand side effects. Recent studies suggest that mesenchyma…
Protective Effect of Black Rice Extract Cream on Ultraviolet B-Induced Skin Hyperpigmentation in Mice Open
Background: Hyperpigmentation is a common sign of skin aging caused by prolonged ultraviolet B (UVB) exposure. Black rice (Oryza sativa L. var glutinosa), known for its high antioxidant content, has moisturizing and regenerative properties…
Hypoxia-Induced Mesenchymal Stem Cell Exosomes Modulate Protein Kinase A and VEGFR Expression in Ultraviolet B-Induced Hyperpigmentation in Mice Open
Background: Hyperpigmentation is often exacerbated by ultraviolet-B (UVB) exposure through oxidative stress and activation of pathways like mitogen-activated protein kinase (MAPK) and vascular endothelial growth factor receptor (VEGFR). Cu…
Mesenchymal Stem Cell-Derived Exosomes Enhance FGF-1 and SDF-1 Expression in Rats with Second Degree Burns Open
Background: Second-degree burns cause extensive damage to the skin and pose significant health challenges, with current treatments facing limitations such as donor skin shortages and complications. Fibroblast growth factor 1 (FGF-1) and st…
Inhibition of Cetylpyridinium Chloride against the Growth of Porphyromonas gingivalis Open
Periodontal disease is a prevalent dental and oral health issue within the community, typically commencing with symptoms of gingivitis and potentially advancing to periodontitis. Porphyromonas gingivalis is an obligate anaerobic Gram-negat…
MSC-Exosomes Hypoxia (EH-MSCs) in modulating Apaf-1 and Survivin in UVB-induced skin aging Open
Skin aging is marked by decreased elasticity and increased wrinkle formation, often associated with altered expression of key genes such as APAF-1 and Survivin. Exposure to UVB radiation, particularly in tropical regions, accelerates colla…
Potential of Glycine max-Based Cream in Restoring Skin Structure Through PDGF and Collagen Modulation After UVB Exposure Open
Premature aging is caused by excessive activity in the sun, causing oxidative stress and inflammatory reactions, which include changes in skin structure such as shortening and thickening of collagen fibers, damage to elastic fibers, and ch…
Secretome of Human MSC Gel Improves DFU Healing through NF-κB p50 and CD163 mRNA Expression Open
Background and Objective: Diabetic foot ulcers (DFUs) remain a critical clinical problem and stem cell-derived secretome reared under hypoxic conditions has been shown to play a significant role in tissue repair via immunomodulation. This …
Hypoxia-conditioned mesenchymal stem cells (MSC) exosomes attenuate ultraviolet-B (UVB)-mediated malondialdehyde (MDA) and matrix metalloproteinase-1 (MMP)-1 upregulation in collagen loss models Open
<p><strong>Aim</strong> To investigate the effects of exosome-derived human mesenchymal stem cells (EH-MSCs) on matrix metalloproteinase-1 (MMP)-1 and malondialdehyde (MDA) levels in ultraviolet-B (UVB)-irradiated Wistar …
The Role of MSC-Derived Exosomes in Soft Tissue Remodelling via the PTEN and PI3K/AKT Pathway Following Wide Excision of Fibrosarcoma: A Review Open
Fibrosarcoma is a neoplasm of fibroblast tissue with varying collagen production. Fibrosarcoma, an aggressive form of soft tissue cancer, is currently a major challenge in the field of oncology. Although its prevalence is relatively low co…
View article: Synergistic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells Secretome and Alkaline Water in Alleviating Oxidative Stress and Inflammation in Type 2 Diabetic Rats.
Synergistic Effects of Hypoxia-Preconditioned Mesenchymal Stem Cells Secretome and Alkaline Water in Alleviating Oxidative Stress and Inflammation in Type 2 Diabetic Rats. Open
These findings highlight the potential of SH-MSC and alkaline water as a novel therapeutic strategy for alleviating T2DM.
The Effect of Celery Extract on Caspase-3 and TNF-α Gene Expression in Lead Poisoning-Induced Renal Injury in Rats Open
Background To determine the effect of Apium graveolens L (Celery) extract in the TNF-α and caspase-3 gene expression on the lead poisoning-induced renal injury rats’ model. Methods This study is experimental research with post test only co…
Anti-inflammatory and antioxidant effects of sea cucumber extract in mitigating hepatic TNF-α elevation induced by high-fat diet Open
High-fat diets contribute to the generation of free radicals, which subsequently induce oxidative stress. Prolonged oxidative stress can lead to cellular necrosis and initiate inflammatory processes. The sea cucumber (Phyllophorus sp.) is …
Enhanced Third Degree Burn Wound Healing by Hypoxic Mesenchymal Stem Cells' Secretome: IL-10 Upregulation and TNF-α/PGE2 Suppression Open
Background: Severe third-degree burns pose a notable obstacle in clinical settings, frequently leading to hindered healing of wounds and the development of scars. In this research, we explored how the secretome of hypoxic mesenchymal stem …
Moringa oleifera leaf extract ameliorates collagen degradation via the inhibition of MMP‐3 expression in UVB‐induced rats Open
Prolonged exposure to high‐intensity UVB induces the formation of reactive oxygen species (ROS) in skin tissue, triggering an increase in matrix metalloproteinase‐3 (MMP‐3) enzyme production and leading to collagen degradation. Moringa ole…
Enhanced Wound Healing in Superficial Infection Wounds Through α-SMA Upregulation and Collagen Density Increase by Secretome Hypoxia Mesenchymal Stem Cells Open
Background: Superficial wound infections lead to delayed remodeling due to the suppression of alpha-smooth muscle actin (α-SMA) gene expression, thus inhibiting collagen synthesis. Secretomes from hypoxia mesenchymal stem cells (SH-MSCs) c…
Mesenchymal stem cells suppress inflammation by downregulating interleukin-6 expression in intestinal perforation animal model Open
Introduction: Intestinal perforation has significant fatality due to sepsis contamination and prolonged inflammation. Studies showed that mesenchymal stem cells (MSCs) secreted cytokines and growth factors to reduce inflammation. This stud…
The Effect of Habbatussauda (Nigella sativa) on TNF-α and IL-6 Levels in Wistar Rats Induced High Fat Diet Open
Habbatussauda (Nigella sativa) contains the active substance thymoquinone which has antihypercholesterolemic, antioxidant, and anti-inflammatory effects. Administration of Habbatussauda oil can improve TNF-α and IL-6 levels in hypercholest…
Therapeutic Potential of Secretome Hypoxia Mesenchymal Stem Cells: Downregulation of TNF-α and HIF-2α in Metabolic Syndrome-Induced Inflammation in Wistar Rats Open
Background: Metabolic syndrome (MetS) has become a global health challenge with several associated issues, such as obesity, insulin resistance, dyslipidemia, and hypertension. Important proteins such as Tumor Necrosis Factor-alpha (TNF-α) …
Effect of Pomegranate Extract Topical Cream (Punica granatum) on SOD and TNF-α Levels in Wistar Rats Excision Wound Model Open
Wounds cause damage or loss of skin tissue components. The body will respond and trigger the wound healing process. Neutrophils will trigger the pro-inflammatory mediator, Tumor Necrosis Factor alpha (TNF-α) which is useful for starting in…
Unveiling Paclitaxel-Induced Mesenchymal Stem Cells: orchestrating Nrf2 Modulation and Apoptosis in CD44+/CD24- Cancer Stem Cells Open
Paclitaxel-induced MSCs decreased Nrf2 expression and significantly decreased CSC viability while enhancing apoptosis. This suggests a potential strategy to mitigate paclitaxel resistance in CD44+/CD24- CSCs. Leveraging Paclitaxel-induced …
Synergistic Cytotoxicity of 5-Fluorouracil and Epigallocatechin-3-Gallate on Colorectal Cancer Stem Cell Open
Background: Colorectal cancer stem cells (CR-CSCs) derived from the HCT-116 cell line established human colon carcinoma cell line, validated with CD44+/CD133+. The study investigates the synergistic effects of combining epigallocatechin ga…
The Role of Mesenchymal Stem Cells Secretome in Regeneration of Thyroid Tissue Damage after Thyroid Lobectomy: A Literature Review Open
Mesenchymal Stem Cells (MSC) are a type of stem cell that is multipotent and originates from the mesoderm and ectoderm at an early stage of development and can differentiate into: 1. Ectodermal derivatives such as: neurons, keratocytes and…
Optimization of PD-1 / PD-L1 Blockade to Increase NK Cells Cytotoxicity in Killing Cancer Cells: Article Review” Open
Anti-PD-1 and anti-PD-L1 are therapies that have shown success in cancer treatment. However, while treating cancer with PD-1/PD-L1 blockade is similar, the clinical response rate is still low in certain cancers at around 40%. Therefore, th…
Targeting Unique Features of Quiescent Cancer Stem Cells to Overcome Resistance and Recurrence in Cancer Therapy: A Review Open
Quiescent cancer stem cells (QCSC) are non-proliferating cells that survive in the G0 phase and have low ki-67 expression and high p27 expression. QCSCs have the ability to evade most chemotherapy, and some subsequent treatments may result…
Apoptotic Effects of Adipose-Derived Stem Cell Secretome in Breast Cancer Stem Cells: A Literature Review Open
Adipose-derived stem cells (ASC) are cells from the core of fat tissue that secrete various cytokines, growth factors, proteins and extracellular vesicles that can be used in regenerative therapy, especially in the case of cancer. This ASC…
Effect of Petai Bark Extract Gel on Tyrosinase and TRP1 Gene Expression (In Vivo Experimental Study on Hyperpigmented Wistar Mice Exposed to UVB Model) Open
UVB irradiation can induce the formation of Reactive Oxygen Species (ROS) which causes activation of melanin synthesis through activation of tyrosinase and tyrosinase related protein-1 (TRP1). Secondary metabolites contained in petai peel …
Secretome of Hypoxia-Preconditioned Mesenchymal Stem Cells Ameliorates Hyperglycemia in Type 2 Diabetes Mellitus Rats Open
Introduction: Type 2 diabetes mellitus (T2DM) is a prevalent form of diabetes that affects 90 - 95 % of all diabetic patients. Insulin sensitizers and insulin exogenous supply could temporarily ameliorate hyperglycaemia; however, they are …