Sunbin Ling
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View article: Stemness- and hypoxia-based prognostic stratification index reveals G6PD as a regulator of hypoxia-driven stemness in hepatocellular carcinoma
Stemness- and hypoxia-based prognostic stratification index reveals G6PD as a regulator of hypoxia-driven stemness in hepatocellular carcinoma Open
Background The positive feedback loop between cancer stemness and the hypoxic microenvironment is a critical driver of hepatocellular carcinoma (HCC) progression. Analyzing their interaction in HCC is crucial to characterize immune microen…
View article: Primary signet ring cell carcinoma of the female urethra: A case report
Primary signet ring cell carcinoma of the female urethra: A case report Open
BACKGROUND Primary signet ring cell carcinoma of the urethra in women is an exceedingly rare malignancy. It was first reported in postmenopausal women in 1987, and only five patients have been reported to date. CASE SUMMARY A 61-year-old w…
View article: Multi-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients beyond the Milan criteria
Multi-omic analysis reveals a CAF-stemness-governed classification in HCC liver transplant recipients beyond the Milan criteria Open
View article: Clinical challenges and research perspectives in liver transplant oncology
Clinical challenges and research perspectives in liver transplant oncology Open
View article: The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma
The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma Open
View article: An E2F7/TSC1-based model for predicting the efficacy of sirolimus after liver transplantation for hepatocellular carcinoma beyond the Milan criteria
An E2F7/TSC1-based model for predicting the efficacy of sirolimus after liver transplantation for hepatocellular carcinoma beyond the Milan criteria Open
To the Editor: As a radical treatment for hepatocellular carcinoma (HCC), liver transplantation (LT) has become an ideal treatment option for certain HCC patients. For patients beyond the Milan criteria, high HCC recurrence risk is a vital…
View article: mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma
mTOR inhibitor reduces nontumour-related death in liver transplantation for hepatocellular carcinoma Open
View article: Unveiling the Role of Mechanical Microenvironment in Hepatocellular Carcinoma: Molecular Mechanisms and Implications for Therapeutic Strategies
Unveiling the Role of Mechanical Microenvironment in Hepatocellular Carcinoma: Molecular Mechanisms and Implications for Therapeutic Strategies Open
Hepatocellular carcinoma (HCC) is the sixth most common cancer in the world and the third leading cause of cancer deaths globally. More than 80% of HCC patients have a background of fibrosis or cirrhosis, which leads to changes in physical…
View article: Ubiquitin‐specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma
Ubiquitin‐specific protease 22 promotes tumorigenesis and progression by an FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma Open
Ubiquitin‐specific protease 22 (USP22) has been identified as a potential marker for cancer stem cells in hepatocellular carcinoma (HCC). It can promote HCC stemness, which is considered a driver of tumorigenesis. Here, we sought to determ…
View article: Bone marrow-derived mesenchymal stem cells reactive oxygen species-responsively secreting hepatocyte growth factor for effective treatment of ischemia-reperfusion injury in liver transplantation
Bone marrow-derived mesenchymal stem cells reactive oxygen species-responsively secreting hepatocyte growth factor for effective treatment of ischemia-reperfusion injury in liver transplantation Open
Background: Ischemia-reperfusion injury (IRI) in liver transplantation is a key factor, impairing the clinical efficacy of liver transplantation.After liver reperfusion, reactive oxygen species (ROS) generated from stressed hepatocytes wou…
View article: TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma
TP53/mTORC1-mediated bidirectional regulation of PD-L1 modulates immune evasion in hepatocellular carcinoma Open
Background Immunotherapy has facilitated great breakthroughs in the treatment of hepatocellular carcinoma (HCC). However, the efficacy and response rate of immunotherapy are limited and vary among different patients with HCC. TP53 mutation…
View article: Insights into the history and tendency of liver transplantation for liver cancer: a bibliometric-based visual analysis
Insights into the history and tendency of liver transplantation for liver cancer: a bibliometric-based visual analysis Open
Research on liver transplantation (LT) for liver cancer has gained increasing attention. This paper has comprehensively described the current status, hotspots and trends in this field. A total of 2991 relevant articles from 1 January 1963 …
View article: USP22 promotes tumorigenesis and progression by a FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma
USP22 promotes tumorigenesis and progression by a FKBP12/mTORC1/autophagy positive feedback loop in hepatocellular carcinoma Open
Background: Ubiquitin-specific protease 22 (USP22) was a potential cancer stem cell (CSC) marker and could promote hepatocellular carcinoma (HCC) stemness upon tumor protein P53 (TP53) inactivation, which have been viewed as drivers of tum…
View article: The predictive value of the modified AFP model for liver transplantation outcomes in multinodular hepatocellular carcinoma patients
The predictive value of the modified AFP model for liver transplantation outcomes in multinodular hepatocellular carcinoma patients Open
View article: PDZ‐binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway
PDZ‐binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway Open
The therapeutic effects of existing drug regimens against pancreatic neuroendocrine neoplasms (pNENs) remain limited, and identifying ideal therapeutic targets is warranted. PDZ binding kinase (PBK) may play an oncogenic role in most solid…
View article: Clinical practice guideline on liver transplantation for hepatocellular carcinoma in China (2021 edition)
Clinical practice guideline on liver transplantation for hepatocellular carcinoma in China (2021 edition) Open
Hepatocellular carcinoma (HCC) is the main cause of cancer-related deaths in adult men under the age of 60 years in China.[1] Liver transplantation (LT) is generally recognized as one of the most effective therapeutic approaches for end-st…
View article: RNA binding protein-based risk score model for prognosis prediction of patients with hepatocellular carcinoma
RNA binding protein-based risk score model for prognosis prediction of patients with hepatocellular carcinoma Open
To the Editor: Liver cancer is estimated to be the sixth most lethal tumor, representing approximately 5.0% of all cancer-related deaths.[1] Mainly due to the high rate of infection with hepatitis B virus, liver cancer remains a serious he…
View article: Novel γδ T cell-based prognostic signature to estimate risk and aid therapy in hepatocellular carcinoma
Novel γδ T cell-based prognostic signature to estimate risk and aid therapy in hepatocellular carcinoma Open
View article: Role of surgical treatments in high-grade or advanced gastroenteropancreatic neuroendocrine neoplasms
Role of surgical treatments in high-grade or advanced gastroenteropancreatic neuroendocrine neoplasms Open
Over the last 40 years, the incidence and prevalence of gastroenteropancreatic neuroendocrine neoplasms (GEP-NENs) have continued to increase. Compared to other epithelial neoplasms in the same organ, GEP-NENs exhibit indolent biological b…
View article: [Corrigendum] Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel‑7402/5‑fluorouracil cells
[Corrigendum] Metformin reverses multidrug resistance in human hepatocellular carcinoma Bel‑7402/5‑fluorouracil cells Open
Subsequently to the publication of the above paper, the authors have reviewed its content and the primary data, and have realized that the western blots selected to show the β‑actin experiments featured in Fig. 4A and Fig. 3C were the same…
View article: Polyploidy Spectrum Correlates with Immunophenotype and Shapes Hepatocellular Carcinoma Recurrence Following Liver Transplantation
Polyploidy Spectrum Correlates with Immunophenotype and Shapes Hepatocellular Carcinoma Recurrence Following Liver Transplantation Open
Polyploid spectra are associated with tumor immunophenotype and provide supplementary prognostic information in LT for HCC.
View article: Additional file 1 of Novel γδ T cell-based prognostic signature to estimate risk and aid therapy in hepatocellular carcinoma
Additional file 1 of Novel γδ T cell-based prognostic signature to estimate risk and aid therapy in hepatocellular carcinoma Open
Additional file 1.
View article: PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors
PDZ Binding Kinase/T-LAK Cell-Derived Protein Kinase Plays an Oncogenic Role and Promotes Immune Escape in Human Tumors Open
Background. PDZ binding kinase (PBK)/T-LAK cell-derived protein kinase (TOPK) is an important mitotic kinase that promotes tumor progression in some cancers. However, the pan-cancer analysis of PBK/TOPK and its role in tumor immunity are l…
View article: The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance
The metabolic flexibility of quiescent CSC: implications for chemotherapy resistance Open
View article: Menin‐regulated Pbk controls high fat diet‐induced compensatory beta cell proliferation
Menin‐regulated Pbk controls high fat diet‐induced compensatory beta cell proliferation Open
Pancreatic beta cells undergo compensatory proliferation in the early phase of type 2 diabetes. While pathways such as FoxM1 are involved in regulating compensatory beta cell proliferation, given the lack of therapeutics effectively target…
View article: Hepatocellular Carcinoma: Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy (Adv. Sci. 5/2021)
Hepatocellular Carcinoma: Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy (Adv. Sci. 5/2021) Open
Resistance to sorafenib remains one of the biggest concerns for hepatocellular carcinoma treatment. In article number 2003042, Xiao Xu, Jiajia Xiang, and co‐workers developed a self‐activated sorafenib and USP22 shRNA codelivery nanoplatfo…
View article: RAP1GAP is a novel marker of trabecular pattern and poor sorafenib treatment response in hepatocellular carcinoma
RAP1GAP is a novel marker of trabecular pattern and poor sorafenib treatment response in hepatocellular carcinoma Open
Background The trabecular pattern is one of the most common features of hepatocellular carcinoma (HCC). In this study, we aimed to identify the molecular mechanisms underlying different trabecular patterns in HCC, and their interaction wit…
View article: Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy
Self‐Activated Cascade‐Responsive Sorafenib and USP22 shRNA Co‐Delivery System for Synergetic Hepatocellular Carcinoma Therapy Open
Resistance to sorafenib severely hinders its effectiveness against hepatocellular carcinoma (HCC). Cancer stemness is closely connected with resistance to sorafenib. Methods for reversing the cancer stemness remains one of the largest conc…
View article: “Sweet tooth”-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy
“Sweet tooth”-oriented SN38 prodrug delivery nanoplatform for targeted gastric cancer therapy Open
Motivated by the overexpression of GLUT1 in gastric cancer, a targeted SN38 prodrug delivery nanoplatform was constructed and exhibited potent antitumor efficiency, which brought a new insight to the design of nanomedicine against cancer.
View article: Sirolimus-based immunosuppression improves outcomes in liver transplantation recipients with hepatocellular carcinoma beyond the Hangzhou criteria
Sirolimus-based immunosuppression improves outcomes in liver transplantation recipients with hepatocellular carcinoma beyond the Hangzhou criteria Open
SRL can improve survival outcomes in LT patients with HCC exceeding the Hangzhou criteria.