Eun Sook Lee
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View article: Neoadjuvant palbociclib in women with operable, hormone receptor-positive breast cancer
Neoadjuvant palbociclib in women with operable, hormone receptor-positive breast cancer Open
The addition of a cyclin-dependent kinase 4/6 (CDK4/6) inhibitor to endocrine therapy augments biological response in breast cancer. This phase III randomized, double-blind study evaluated the efficacy of adding palbociclib to neoadjuvant …
View article: Multi-Ancestry Transcriptome-wide Association Studies Uncover New Insights into Breast Cancer Genetics and Biology
Multi-Ancestry Transcriptome-wide Association Studies Uncover New Insights into Breast Cancer Genetics and Biology Open
Genome-wide association studies (GWAS) have identified over 200 genetic risk loci for breast cancer, yet the target genes in these loci remain largely unknown. To address this knowledge gap, we conducted a series of multi-ancestry transcri…
View article: Impact of a 24-Week Mobile App–Based Human Coaching Program on Body Composition and Lipid Metabolism in Breast Cancer Survivors With Overweight or Obesity: Single-Arm Prospective Cohort Study
Impact of a 24-Week Mobile App–Based Human Coaching Program on Body Composition and Lipid Metabolism in Breast Cancer Survivors With Overweight or Obesity: Single-Arm Prospective Cohort Study Open
Background Overweight or obesity is a prognostic factor for breast cancer recurrence and breast cancer–related deaths. However, weight control is difficult for breast cancer survivors because of menopause, chemotherapy, antihormonal therap…
View article: Dietary isoflavone intake among breast cancer survivors and cancer-free women
Dietary isoflavone intake among breast cancer survivors and cancer-free women Open
Breast cancer survivors were more likely to consume isoflavones than age-matched cancer-free women. Dietary isoflavone intake was associated with healthy lifestyle characteristics in women both with and without breast cancer. Further resea…
View article: Progranulin and Breast Cancer Mortality: 13-Year Follow-Up of a Cohort Study
Progranulin and Breast Cancer Mortality: 13-Year Follow-Up of a Cohort Study Open
Pre-operative serum PGRN levels had clinical significance for predicting cancer mortality in breast cancer patients independent of tumor stage and metabolic parameters, especially in HR-positive tumors.
View article: Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment
Disease-microenvironment modulation by bare- or engineered-exosome for rheumatoid arthritis treatment Open
Background Exosomes are extracellular vesicles secreted by eukaryotic cells and have been extensively studied for their surface markers and internal cargo with unique functions. A deeper understanding of exosomes has allowed their applicat…
View article: Determining the Factors Predicting the Response to Anti-HER2 Therapy in HER2-Positive Breast Cancer Patients
Determining the Factors Predicting the Response to Anti-HER2 Therapy in HER2-Positive Breast Cancer Patients Open
Purpose We aimed to identify the differently expressed genes or related pathways associated with good responses to anti-HER2 therapy and to suggest a model for predicting drug response in neoadjuvant systemic therapy with trastuzumab in HE…
View article: Differences in Willingness to Undergo BRCA1/2 Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey
Differences in Willingness to Undergo BRCA1/2 Testing and Risk Reducing Surgery among the General Public, Cancer Patients, and Healthcare Professionals: A Large Population-Based Survey Open
We aimed to understand the decision-making process related to the willingness to undergo BRCA1/2 genetic testing, risk-reducing salpingo-oophorectomy (RRSO), or risk-reducing mastectomy (RRM) among the general public, cancer patients, and …
View article: Determining the Factors Predicting the Response to Anti-HER2 Therapy in HER2-Positive Breast Cancer Patients
Determining the Factors Predicting the Response to Anti-HER2 Therapy in HER2-Positive Breast Cancer Patients Open
Purpose: We aimed to identify the overexpressed genes or related pathways associated with good responses to anti-HER2 therapy and to suggest a model for predicting drug response in neoadjuvant systemic therapy with trastuzumab in HER2-posi…
View article: Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women
Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction Among Asian Women Open
In this study, PRSs derived using breast cancer risk-associated SNVs had similar predictive performance in Asian and European women. Including nongenetic risk factors in models further improved prediction accuracy. These findings support t…
View article: Therapeutic Targeting of DNA Damage Response in Cancer
Therapeutic Targeting of DNA Damage Response in Cancer Open
DNA damage response (DDR) is critical to ensure genome stability, and defects in this signaling pathway are highly associated with carcinogenesis and tumor progression. Nevertheless, this also provides therapeutic opportunities, as cells w…
View article: Low incidence of lymph node metastasis in patients with microinvasive breast cancer: a Korean nationwide study
Low incidence of lymph node metastasis in patients with microinvasive breast cancer: a Korean nationwide study Open
The incidence of LNM in MIBC patients was only 4.0% in our study, suggesting that de-escalation of axillary surgical interventions could be carefully considered. The indications for axillary staging should be individualized considering tum…
View article: Targeted next generation sequencing of circulating tumor DNA provides prognostic information for management in breast cancer patients
Targeted next generation sequencing of circulating tumor DNA provides prognostic information for management in breast cancer patients Open
The genomic profile of ctDNA reflects and provides additional information to the tumor DNA genome profile. Follow-up monitoring of mutations detected in ctDNA is useful in the clinical management of breast cancer patients.
View article: Continuous centrifugal microfluidics (CCM) isolates heterogeneous circulating tumor cells via full automation
Continuous centrifugal microfluidics (CCM) isolates heterogeneous circulating tumor cells via full automation Open
Understanding cancer heterogeneity is essential to finding diverse genetic mutations in metastatic cancers. Thus, it is critical to isolate all types of CTCs to identify accurate cancer information from patients. Moreover, full automation …
View article: Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors
Fear of Cancer Recurrence and Its Negative Impact on Health-Related Quality of Life in Long-term Breast Cancer Survivors Open
Purpose Fear of cancer recurrence (FCR) is a common psychological issue in breast cancer (BC) survivors during early survivorship but whether the same is true among long-term survivors has yet to be empirically evaluated. This study invest…
View article: Clinical Effectiveness of Hypofractionated Proton Beam Therapy for Liver Metastasis From Breast Cancer
Clinical Effectiveness of Hypofractionated Proton Beam Therapy for Liver Metastasis From Breast Cancer Open
Background Few studies of proton beam therapy (PBT) for patients with liver metastasis from breast cancer (LMBC) are available to date. The aim of the present study was to evaluate the clinical effectiveness of PBT for patients with LMBC. …
View article: Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction among Asian Women, Results from Asia Breast Cancer Consortium
Incorporating Polygenic Risk Scores and Nongenetic Risk Factors for Breast Cancer Risk Prediction among Asian Women, Results from Asia Breast Cancer Consortium Open
Importance Polygenic risk scores (PRSs) have shown promises in breast cancer risk prediction; however, limited studies have been conducted among Asian women. Objective To develop breast cancer risk prediction models for Asian women incorpo…
View article: Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study
Clinical impact of follow‐up imaging on mortality in Korean breast cancer patients: A national cohort study Open
Background As the incidence of breast cancer has increased and the survival rate has improved, supporting the optimal follow‐up strategy has become an important issue. This study aimed to evaluate follow‐up imaging usage after breast cance…
View article: Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality
Effectiveness of the Korean National Cancer Screening Program in reducing breast cancer mortality Open
High incidences of breast cancer (BC) are reported in Asian women in their forties, and it is not clear whether mammographic screening reduces mortality among them. This study evaluated the effect of BC screening on mortality in Korea. We …
View article: Awareness, Knowledge, Perceived Benefits, and Barriers Regarding Precision Medicine and Willingness to Participate in a National Registry: Comparison of Cancer Patients and the General Population
Awareness, Knowledge, Perceived Benefits, and Barriers Regarding Precision Medicine and Willingness to Participate in a National Registry: Comparison of Cancer Patients and the General Population Open
Background Precision medicine (PM) is a growing area of interest in cancer care. However, relatively little is known about the public attitudes toward PM and the factors associated with the willingness to participate in the construction of…
View article: Guidelines for Cancer Care during the COVID-19 Pandemic in South Korea
Guidelines for Cancer Care during the COVID-19 Pandemic in South Korea Open
At the end of 2019, the cause of pneumonia outbreaks in Wuhan, China, was identified as severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. In February 2020, the World Health Organization named the disease cause by SARS…
View article: Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score Open
View article: Survival in untreated hepatocellular carcinoma: A national cohort study
Survival in untreated hepatocellular carcinoma: A national cohort study Open
This study aimed to analyze the proportion, characteristics and prognosis of untreated hepatocellular carcinoma (HCC) patients in a large representative nationwide study. A cohort study was conducted using the National Health Insurance Ser…
View article: Criteria for identifying residual tumours after neoadjuvant chemotherapy of breast cancers: a magnetic resonance imaging study
Criteria for identifying residual tumours after neoadjuvant chemotherapy of breast cancers: a magnetic resonance imaging study Open
View article: Analysis of risk factors associated with survival in human epidermal growth factor receptor 2-positive ductal carcinoma <i>in situ</i> using Korean Breast Cancer Society Database
Analysis of risk factors associated with survival in human epidermal growth factor receptor 2-positive ductal carcinoma <i>in situ</i> using Korean Breast Cancer Society Database Open
Advanced age, higher BMI, mastectomy, and the absence of endocrine therapy were factors associated with poor survival of patients with HER2-positive DCIS. This finding requires further validation combined with additional analysis of large …
View article: The Effects of Emotional Labor and Job Exhaustion of Art Psychology Counselors on Life Satisfaction
The Effects of Emotional Labor and Job Exhaustion of Art Psychology Counselors on Life Satisfaction Open
View article: Sentinel Lymph Node Biopsy in Breast Cancer Patients With Pathological Complete Response in the Axillary Lymph Node After Neoadjuvant Chemotherapy
Sentinel Lymph Node Biopsy in Breast Cancer Patients With Pathological Complete Response in the Axillary Lymph Node After Neoadjuvant Chemotherapy Open
As an alternative to ALND, SLNB has oncological safety in patients with axillary pathological complete response after NAC.
View article: Data and metadata supporting the article: Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score
Data and metadata supporting the article: Systematic evaluation of scoring methods for Ki67 as a surrogate for 21-gene recurrence score Open
Although Ki67 labeling index is a potential predictive marker for chemotherapy benefit, its clinical utility has been limited by the lack of a standard scoring method resulting in poor inter-observer reproducibility. Especially, there is n…
View article: The Effects of Emotional Labor of Workers in Elderly Nursing Home on their Job Attitude
The Effects of Emotional Labor of Workers in Elderly Nursing Home on their Job Attitude Open
The purpose of this study is to investigate the effects of emotional labor on job attitudes of elderly nursing facility workers.For the study, 120 elderly nursing facility workers in OO city, Gangwon-do were investigated.For the analysis m…
View article: Exon splicing analysis of intronic variants in multigene cancer panel testing for hereditary breast/ovarian cancer
Exon splicing analysis of intronic variants in multigene cancer panel testing for hereditary breast/ovarian cancer Open
The use of multigene panel testing for patients with a predisposition to breast/ovarian cancer is increasing as the identification of variants is useful for diagnosis and disease management. We identified pathogenic and likely pathogenic (…