Sungsin Jo
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View article: Host Translational Control by Stress Granules Promotes <i>Mycobacterium tuberculosis</i> Pathogenesis
Host Translational Control by Stress Granules Promotes <i>Mycobacterium tuberculosis</i> Pathogenesis Open
Stress granules (SGs) are cytoplasmic condensates that regulate mRNA translation and signaling in response to stress. Although SGs have been widely studied in antiviral responses, their function in bacterial infections is not well understo…
View article: Gene Profiling Analyses of Synovium Tissues in Korean Osteoarthritis Patients
Gene Profiling Analyses of Synovium Tissues in Korean Osteoarthritis Patients Open
We identified 11 candidate genes associated with immune responses that are abnormally overexpressed in the synovium tissues of Korean osteoarthritis patients. Establishment of the strategies for targeting these genes may help alleviate pai…
View article: Inflammation increases the penetrance of behavioral impairment in <i>Shank3</i> haploinsufficiency mice – can it explain the behavioral regression in Autism?
Inflammation increases the penetrance of behavioral impairment in <i>Shank3</i> haploinsufficiency mice – can it explain the behavioral regression in Autism? Open
Behavioral regression occurs in ∼40% of SHANK3 -associated autism spectrum disorder (ASD). We previously reported that significant behavioral regression in a small cohort with SHANK3 haploinsufficiency patients, triggered by subclinical in…
View article: Oral–gut microbiome axis in a Korean cohort with inflammatory bowel disease and ankylosing spondylitis (INTEGRATE): a prospective and observational study protocol
Oral–gut microbiome axis in a Korean cohort with inflammatory bowel disease and ankylosing spondylitis (INTEGRATE): a prospective and observational study protocol Open
Introduction The global burden of chronic immune-mediated inflammatory diseases (IMIDs) is increasing, and rising prevalence rates significantly affect socioeconomic factors and quality of life. Inflammatory bowel disease (IBD), including …
View article: Erratum to: Celecoxib is the only nonsteroidal anti-inflammatory drug to inhibit bone progression in spondyloarthritis.
Erratum to: Celecoxib is the only nonsteroidal anti-inflammatory drug to inhibit bone progression in spondyloarthritis. Open
[Erratum to: BMB Reports 2025; 58(3): 140-145, PMID: 39757202, PMCID: PMC11955732] The BMB Reports would like to issue a correction to an article published in BMB Rep. 58(3): 140-145, titled "Celecoxib is the only nonsteroidal anti-inflamm…
View article: Microbiome Composition of <scp><i>Haemaphysalis flava</i></scp> in Korea and Diversity Analysis Based on Region, Developmental Stage, and Sex
Microbiome Composition of <span><i>Haemaphysalis flava</i></span> in Korea and Diversity Analysis Based on Region, Developmental Stage, and Sex Open
Ticks are well‐known vectors of various diseases and are widely distributed globally. In this study, we investigated the microbial community of Haemaphysalis flava , a common tick species in Korea, using 16S rRNA gene analysis. Alpha diver…
View article: Factors associated with anti-drug antibody production in ankylosing spondylitis patients treated with the infliximab biosimilar CT-P13
Factors associated with anti-drug antibody production in ankylosing spondylitis patients treated with the infliximab biosimilar CT-P13 Open
Smoking is identified as a significant risk factor for elevated ADAs in AS patients treated with CT-P13. The findings underscore the importance of smoking-cessation strategies in the management of AS patients.
View article: Wnt5a exacerbates pathological bone features and trabecular bone loss in curdlan-injected SKG mice via osteoclast activation
Wnt5a exacerbates pathological bone features and trabecular bone loss in curdlan-injected SKG mice via osteoclast activation Open
Many studies on osteoblasts have suggested that Wnt5a plays a crucial role in excessive osteoblast activity, which is responsible for ectopic new bone formation, but research on osteoclasts in ankylosing spondylitis (AS) remains relatively…
View article: Bach2 repression of CD36 regulates lipid-metabolism-linked effector functions in follicular B cells
Bach2 repression of CD36 regulates lipid-metabolism-linked effector functions in follicular B cells Open
The transcription repressor Bach2 plays a crucial role in shaping humoral immunity, but its cell-autonomous function remains elusive. Here, we reveal the mechanism by which Bach2 regulates effector cell maturation in peripheral B cells. In…
View article: Celecoxib is the only nonsteroidal anti-inflammatory drug to inhibit bone progression in spondyloarthritis
Celecoxib is the only nonsteroidal anti-inflammatory drug to inhibit bone progression in spondyloarthritis Open
Spondyloarthritis (SpA) is a chronic inflammatory disease that leads to ankylosis of the axial skeleton. Celecoxib (cyclooxygenase-2 inhibitor, COX-2i) inhibited radiographic progression in a clinical study of SpA, but in the following stu…
View article: Scaffold-induced compression enhances ligamentization potential of decellularized tendon graft reseeded with ACL-derived cells
Scaffold-induced compression enhances ligamentization potential of decellularized tendon graft reseeded with ACL-derived cells Open
Anterior cruciate ligament (ACL) reconstruction is often performed using a tendon graft. However, the predominant synthesis of fibrotic scar tissue (type III collagen) occurs during the healing process of the tendon graft, resulting in a s…
View article: Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture
Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture Open
These findings indicate the potential of soluble MYH2 protein as a promising therapeutic strategy for promoting endochondral bone formation in chondrocytes following fracture.
View article: Targeting osteoclast-derived DPP4 alleviates inflammation-mediated ectopic bone formation in ankylosing spondylitis.
Targeting osteoclast-derived DPP4 alleviates inflammation-mediated ectopic bone formation in ankylosing spondylitis. Open
Background: Ankylosing spondylitis (AS) is a chronic inflammatory disease characterized by ectopic bone formation. The anti-inflammatory function of dipeptidyl peptidase-4 (DPP4) inhibitor has been reported in bone metabolism, but its util…
View article: Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis
Elevated BMPR2 expression amplifies osteoblast differentiation in ankylosing spondylitis Open
The expression of BMPR2 was found to be significantly increased in facet joint tissues of patients with AS. These findings suggest that BMPR2 may play a role in the BMP2-mediated progression of AS.
View article: Characterization and Neutralization of Pathologic Memory CD4+ T Cells in Spondyloarthritis Synovial Fluid
Characterization and Neutralization of Pathologic Memory CD4+ T Cells in Spondyloarthritis Synovial Fluid Open
Spondyloarthritis (SpA), which has increased T helper 17 (Th17) cell activity, and neutralizing antibodies targeting IL-17 are effective in patients with SpA. However, not all Th17 cells are pathologic; most Th17 cells have physiological r…
View article: Analysis of <scp>Single‐Cell</scp> Transcriptome and Surface Protein Expression in Ankylosing Spondylitis Identifies <scp>OX40</scp>‐Positive and <scp>Glucocorticoid‐Induced</scp> Tumor Necrosis Factor Receptor–Positive Pathogenic Th17 Cells
Analysis of <span>Single‐Cell</span> Transcriptome and Surface Protein Expression in Ankylosing Spondylitis Identifies <span>OX40</span>‐Positive and <span>Glucocorticoid‐Induced</span> Tumor Necrosis Factor Receptor–Positive Pathogenic Th17 Cells Open
Objective To demonstrate the immune landscape of blood and synovial cells in the setting of ankylosing spondylitis (AS) through the analysis of both single‐cell transcriptome and surface protein expression, and to unveil the molecular char…
View article: Extracellular <scp>PPM1A</scp> promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the <scp>FOXO1A‐RUNX2</scp> pathway
Extracellular <span>PPM1A</span> promotes mineralization of osteoblasts differentiation in ankylosing spondylitis via the <span>FOXO1A‐RUNX2</span> pathway Open
Protein phosphatase magnesium‐dependent 1A (PPM1A), serine/threonine protein phosphatase, in sera level was increased in patients with ankylosing spondylitis (AS). Preosteoblasts were differentiated actively to matured osteoblasts by intra…
View article: Angiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis
Angiotensin receptor blockers, but not angiotensin-converting enzyme inhibitors, inhibit abnormal bone changes in spondyloarthritis Open
Background Spondyloarthritis (SpA) is a chronic inflammatory disease that results in bone ankylosis. The tissue renin-angiotensin system (RAS), updated with new components, is an emerging phenomenon possibly implicated in SpA-associated bo…
View article: Dikkopf-1 promotes matrix mineralization of osteoblasts by regulating Ca<sup>+</sup>-CAMK2A- CREB1 pathway
Dikkopf-1 promotes matrix mineralization of osteoblasts by regulating Ca<sup>+</sup>-CAMK2A- CREB1 pathway Open
Other SectionsABSTRACTINTRODUCTIONRESULTSDISCUSSIONMATERIALS AND METHODSACKNOWLEDGEMENTSCONFLICTS OF INTERESTFIGURESREFERENCES
View article: Comparison of ligamentization potential between anterior cruciate ligament-derived cells and adipose-derived mesenchymal stem cells reseeded to acellularized tendon allograft
Comparison of ligamentization potential between anterior cruciate ligament-derived cells and adipose-derived mesenchymal stem cells reseeded to acellularized tendon allograft Open
Aims To test the hypothesis that reseeded anterior cruciate ligament (ACL)-derived cells have a better ability to survive and integrate into tendon extracellular matrix (ECM) and accelerate the ligamentization process, compared to adipose-…
View article: Comparison of a Cryopneumatic Compression Device and Ice Packs for Cryotherapy Following Anterior Cruciate Ligament Reconstruction
Comparison of a Cryopneumatic Compression Device and Ice Packs for Cryotherapy Following Anterior Cruciate Ligament Reconstruction Open
Compared to standard ice packs, application of cryopneumatic compression was associated with a significant reduction in VAS pain scores and joint effusion during the early postoperative period following ACL reconstruction.
View article: House dust mite‐induced <scp>Akt‐ERK1</scp> / <scp>2‐C</scp> / <scp>EBP</scp> beta pathway triggers <scp>CCL20</scp> ‐mediated inflammation and epithelial–mesenchymal transition for airway remodeling
House dust mite‐induced <span>Akt‐ERK1</span> / <span>2‐C</span> / <span>EBP</span> beta pathway triggers <span>CCL20</span> ‐mediated inflammation and epithelial–mesenchymal transition for airway remodeling Open
House dust mite (HDM) allergens cause inflammatory responses and chronic allergic diseases such as bronchial asthma and atopic dermatitis. Here, we investigate the mechanism by which HDM induces C–C chemokine ligand 20 (CCL20) expression t…
View article: Dikkopf-1 promotes matrix mineralization of osteoblasts by regulating Ca+-CAMK2A-CREB
Dikkopf-1 promotes matrix mineralization of osteoblasts by regulating Ca+-CAMK2A-CREB Open
Dickkopf-1 (DKK1) is a secreted protein that acts as an antagonist of the canonical WNT/β-catenin pathway, which regulates osteoblast differentiation. However, the role of DKK1 on osteoblast differentiation has not yet been fully clarified…