Sunhye Lee
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View article: Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
View article: Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq)…
View article: Prediction and Imputation of Missing Values in Canine Joint Data Using Recurrent Neural Networks
Prediction and Imputation of Missing Values in Canine Joint Data Using Recurrent Neural Networks Open
View article: Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Author response: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin. Here, we used deep full-length single-cell RNA-sequencing to distinguish post-mitotic cone and rod developmental states and cone-specific features t…
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq)…
View article: Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features
Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features Open
Human cone photoreceptors differ from rods and serve as the retinoblastoma cell-of-origin, yet the developmental basis for their distinct behaviors is poorly understood. Here, we used deep full-length single-cell RNA-sequencing (scRNA-seq)…
View article: Supplementation of Non-Fermented and Fermented Red Ginseng Improves Obese Phenotypes, Lipid and Inflammatory Profiles, and Antioxidant Defense System in High Fat-Fed Rats
Supplementation of Non-Fermented and Fermented Red Ginseng Improves Obese Phenotypes, Lipid and Inflammatory Profiles, and Antioxidant Defense System in High Fat-Fed Rats Open
Obesity is characterized by excessive fat accumulation, chronic inflammation, and enhanced oxidative stress that can present a substantial risk for metabolic complications. The aim of this study was to investigate the protective effects of…
View article: Supplementary Material for: Association of Carotid Artery Endothelial Signal Intensity Gradient with Unilateral Large Artery Ischemic Stroke
Supplementary Material for: Association of Carotid Artery Endothelial Signal Intensity Gradient with Unilateral Large Artery Ischemic Stroke Open
Background: Common carotid artery (CCA) and internal carotid artery (ICA) are aligned linearly, but their hemodynamic role in ischemic stroke has not been studied in depth. Objectives: We aimed to investigate wh…
View article: Gut microbiota composition modulates inflammation and structure of the vagal afferent pathway
Gut microbiota composition modulates inflammation and structure of the vagal afferent pathway Open
View article: 2’-fucosyllactose (2’-FL) Supplementation Improves Gut Barrier Function and Lipid Metabolism in HF-fed Mice
2’-fucosyllactose (2’-FL) Supplementation Improves Gut Barrier Function and Lipid Metabolism in HF-fed Mice Open
OBJECTIVES: 2’-fucosyllactose (2’-FL), the most predominant oligosaccharide found in human milk, acts as a prebiotic with beneficial effects on the host. The aim of this study was to determine the beneficial effect of 2’-FL on intestinal b…
View article: 2′-Fucosyllactose Supplementation Improves Gut-Brain Signaling and Diet-Induced Obese Phenotype and Changes the Gut Microbiota in High Fat-Fed Mice
2′-Fucosyllactose Supplementation Improves Gut-Brain Signaling and Diet-Induced Obese Phenotype and Changes the Gut Microbiota in High Fat-Fed Mice Open
Obesity is characterized by fat accumulation, chronic inflammation and impaired satiety signaling, which may be due in part to gut microbial dysbiosis. Manipulations of the gut microbiota and its metabolites are attractive targets for obes…
View article: Improved Third-Generation Lentiviral Packaging with Plko.1C Vectors
Improved Third-Generation Lentiviral Packaging with Plko.1C Vectors Open
A widely used third-generation lentiviral packaging system produces virus with enhanced biosafety by eliminating HIV accessory genes and separating packaging elements into three different plasmids. However, for certain vectors such as pLKO…
View article: Beneficial Effects of Non-Encapsulated or Encapsulated Probiotic Supplementation on Microbiota Composition, Intestinal Barrier Functions, Inflammatory Profiles, and Glucose Tolerance in High Fat Fed Rats
Beneficial Effects of Non-Encapsulated or Encapsulated Probiotic Supplementation on Microbiota Composition, Intestinal Barrier Functions, Inflammatory Profiles, and Glucose Tolerance in High Fat Fed Rats Open
Development of obesity-associated comorbidities is related to chronic inflammation, which has been linked to gut microbiota dysbiosis. Thus, modulating gut microbiota composition could have positive effects for metabolic disorders, support…
View article: TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling
TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling Open
View article: Rapid tissue histology using multichannel confocal fluorescence microscopy with focus tracking
Rapid tissue histology using multichannel confocal fluorescence microscopy with focus tracking Open
This study confirms the use of confocal fluorescence microscopy technique to acquire rapid pathology results using optical sectioning, line scanning and focus tracking. We anticipate that the presented method will enable intraoperative his…
View article: Developmental-stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors
Developmental-stage-specific proliferation and retinoblastoma genesis in RB-deficient human but not mouse cone precursors Open
Most retinoblastomas initiate in response to the inactivation of the RB1 gene and loss of functional RB protein. The tumors may form without additional genomic changes and develop after a pre-malignant retinoma phase. Despite this seemingl…
View article: Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet–Fed Rats
Blueberry Supplementation Influences the Gut Microbiota, Inflammation, and Insulin Resistance in High-Fat-Diet–Fed Rats Open
View article: Energy‑dense diet triggers changes in gut microbiota, reorganization of gut‑brain vagal communication and increases body fat accumulation
Energy‑dense diet triggers changes in gut microbiota, reorganization of gut‑brain vagal communication and increases body fat accumulation Open
Obesity is associated with consumption of energy-dense diets and development of systemic inflammation. Gut microbiota play a role in energy harvest and inflammation and can influence the change from lean to obese phenotypes. The nucleus of…
View article: A Recently Established Murine Model of Nasal Polyps Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps
A Recently Established Murine Model of Nasal Polyps Demonstrates Activation of B Cells, as Occurs in Human Nasal Polyps Open
Animal model systems are invaluable for examining human diseases. Our laboratory recently established a mouse model of nasal polyps (NPs) and investigated similarities and differences between this mouse model and human NPs. We especially f…
View article: PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness
PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness Open
View article: Wnt2 complements Wnt/β-catenin signaling in colorectal cancer
Wnt2 complements Wnt/β-catenin signaling in colorectal cancer Open
Wnt2 is implicated in various human cancers. However, it remains unknown how Wnt2 is upregulated in human cancer and contributes to tumorigenesis. Here we found that Wnt2 is highly expressed in colorectal cancer (CRC) cells. In addition to…
View article: A Newly Established Murine Model of Nasal Polyps Demonstrates B Cell Activation, Similar to Human Nasal Polyps
A Newly Established Murine Model of Nasal Polyps Demonstrates B Cell Activation, Similar to Human Nasal Polyps Open