Suja Pillai
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Evaluating the Level of Difficulty of University Statistical Course Assessments: A Modern Perspective through Item Analysis Open
University statistics courses serve as critical platforms for developing learners' mathematical thinking, problem-solving skills, and analytical abilities. To gauge the effectiveness of these courses and to provide learners with a fair and…
View article: Roles of long noncoding <scp>RNA</scp> in triple‐negative breast cancer
Roles of long noncoding <span>RNA</span> in triple‐negative breast cancer Open
Introduction Long noncoding RNAs (lncRNAs) play crucial roles in regulating various hallmarks in cancers. Triple‐negative (Estrogen receptor, ER; Human epidermal growth factor receptor 2, HER2; Progesterone receptor, PR) breast cancer (TNB…
Implications of estrogen and its receptors in colorectal carcinoma Open
Estrogens have been implicated in the pathogenesis of various cancer types, including colorectal carcinoma (CRC). Estrogen receptors such as ERα and ERβ activate intracellular signaling cascades followed by binding to estrogen, resulting i…
Editorial: Recent Advances in Pheochromocytoma and Paraganglioma: Molecular Pathogenesis, Clinical Impacts, and Therapeutic Perspective Open
In this Research Topic, we have collected recent developments in research into Pheochromocytomas and Paragangliomas (PPGLs), highlighting their molecular mechanisms, clinical manifestations, and improved therapeutic management.\n\nPPGLs ar…
Identification of novel mutations and functional impacts of EPAS1 in colorectal cancer Open
Endothelial PAS domain‐containing protein 1 (EPAS1) has implications in many cancers. However, the molecular behaviours, functional roles and mutational status of EPAS1 have never been studied in colorectal carcinoma (CRC). The study aims …
VEGF-A/VEGF-B/VEGF-C expressions in non-hereditary, non-metastatic phaeochromocytoma. Open
Vascular endothelial growth factor (VEGF) is important in pathogenesis of different cancers. The aim of this study is to investigate the relationships between different VEGFs and clinicopathological factors in patients with phaeochromocyto…
Identification of Novel Mutations and Expressions of EPAS1 in Phaeochromocytomas and Paragangliomas Open
Endothelial PAS domain-containing protein 1 (EPAS1) is an oxygen-sensitive component of the hypoxia-inducible factors (HIFs) having reported implications in many cancers by inducing a pseudo-hypoxic microenvironment. However, the molecular…
Molecular Deregulation of EPAS1 in the Pathogenesis of Esophageal Squamous Cell Carcinoma Open
Endothelial PAS domain-containing protein 1 (EPAS1) is an angiogenic factor and its implications have been reported in many cancers but not in esophageal squamous cell carcinoma (ESCC). Herein, we aim to examine the genetic and molecular a…
Novel Therapeutics Against Breast Cancer Stem Cells by Targeting Surface Markers and Signaling Pathways Open
Background: Breast cancer remains to be one of the deadliest forms of cancers, owing to the drug resistance and tumor relapse caused by breast cancer stem cells (BCSCs) despite notable advancements in radio-chemotherapies. Objective: To fi…
Natural Compounds Targeting Cancer Stem Cells: A Promising Resource for Chemotherapy Open
Background: Cancer Stem Cells (CSCs) are the subpopulation of cancer cells which are directly involved in drug resistance, metastases to distant organ and cancer recurrence. Methods: A systematic literature search was conducted through var…
Evaluation of multidisciplinary strategies and traditional approaches in teaching pathology in medical students Open
This study aims to evaluate the impact on the implementation of multiple strategies to improve medical student's pathology learning experience. In two consecutive years, medical students after a whole year of enrolling in pathology teachin…
Promoter hypermethylation inactivate tumor suppressor <i>FAM134B</i> and is associated with poor prognosis in colorectal cancer Open
The present study aims to examine promoter methylation status of FAM134B in a large cohort of patients with colorectal adenocarcinomas. The clinical significances and correlations of FAM134B promoter methylation with its expression are als…
Comparative Studies of Mathematical Literacy/Education: A Literature Review Open
Mathematics cuts across all the fields of human endeavours in its wide application and mind development.Hence, this study focuses on the learners' perception on the importance of utilizing teaching resources in mathematics.It adopted case …
Genetic Profiling of Phaeochromocytoma and Paraganglioma Using Next Generation Sequencer Open
Phaeochromocytoma (PCC) and paraganglioma (PGL) are tumours with neural crest differentiation. They are relatively rare neoplasms, but can be highly malignant, and benign tumours can progress into malignant phenotypes many years after init…
Metastasis-suppressing<i>NID2</i>, an epigenetically-silenced gene, in the pathogenesis of nasopharyngeal carcinoma and esophageal squamous cell carcinoma Open
Nidogen-2 (NID2) is a key component of the basement membrane that stabilizes the extracellular matrix (ECM) network. The aim of the study is to analyze the functional roles of NID2 in the pathogenesis of nasopharyngeal carcinoma (NPC) and …