Explanipedia

Signal-aware synthesis of tissue polarization uniformity from OCT images guided by an SNR-based heuristic Open

Yuheng Wang, Chris Zhou, Jiayue Cai, Xin Lu, Shuo Tang , et al. · 2025

Medico-legal risks associated with laser therapy: A cross-sectional descriptive analysis of closed cases over a 10-year period in Canada Open

Y. Deng, Sunil Kalia, Jeffrey Toy, Chaocheng Liu, Laura Payant , et al. · 2025

Impact of treatment of COVID-19 with sotrovimab on post-acute sequelae of COVID-19 (PASC): an analysis of National COVID Cohort Collaborative (N3C) data Open

Myriam Gharbi, Rose Chang, Tracy Guo, Mei Sheng Duh, Jennifer Han , et al. · 2025

Mission impossible? Caveats in interpreting and comparing long‐term efficacy in biologic studies for moderate‐to‐severe plaque psoriasis Open

Richard G. Langley, Alexander Egeberg, Melinda Gooderham, Robert Bissonnette, Julien Ringuet , et al. · 2025

Motion-tolerant 3D volumetric multimodality microscopy imaging of human skin with subcellular resolution and extended field-of-view Open

Zhenguo Wu, Yunxian Tian, Jianhua Zhao, Yimei Huang, Harvey Lui , et al. · 2025

The skin, the body's largest organ, has a heterogeneous structure with various cell types and tissue layers. In vivo noninvasive 3D volumetric imaging with multi-contrast, high resolution, a large field-of-view (FOV), and no-motion artifac…

Burden of Vitiligo in Canada: Retrospective Analysis of a Canadian Public Claims Database Open

Julien Ringuet, Gloria Hoi Yan Wong, Véronique Baribeau, Sunil Kalia, Josée Brisebois , et al. · 2025

Background: Vitiligo is an autoimmune disease resulting in skin depigmentation. Treatment options are limited. Objectives: To examine disease burden and healthcare resource utilization (HCRU) among patients with vitiligo in Québec, Canada.…

Unlocking the potential of Liver X Receptors: A new era in metabolic regulation Open

Imroze Singh, Sunil Kalia · 2025

Integrating Clinical Knowledge Graphs and Gradient-Based Neural Systems for Enhanced Melanoma Diagnosis via the Seven-Point Checklist Open

Yuheng Wang, Tianze Yu, Jiayue Cai, Sunil Kalia, Harvey Lui , et al. · 2025

The seven-point checklist (7PCL) is a widely used diagnostic tool in dermoscopy for identifying malignant melanoma by assigning point values to seven specific attributes. However, the traditional 7PCL is limited to distinguishing between m…

Comparative effectiveness among BRAF plus MEK inhibitors for patients with BRAF V600-mutant melanoma Open

Gino K. In, K. Chen, Gautam Sajeev, Ryan Simpson, Sunil Kalia , et al. · 2024

Background: Understanding of comparative efficacy of treatments can inform clinical decision-making. This study compared overall survival (OS) and progression-free survival (PFS) across patients with metastatic BRAFV600-mutant melanoma ini…

Precise Serial Microregistration Enables Quantitative Microscopy Imaging Tracking of Human Skin Cells In Vivo Open

Yunxian Tian, Zhenguo Wu, Harvey Lui, Jianhua Zhao, Sunil Kalia , et al. · 2024

We developed an automated microregistration method that enables repeated in vivo skin microscopy imaging of the same tissue microlocation and specific cells over a long period of days and weeks with unprecedented precision. Applying this m…

Improving skin cancer detection by Raman spectroscopy using convolutional neural networks and data augmentation Open

Jianhua Zhao, Harvey Lui, Sunil Kalia, Tim K. Lee, Haishan Zeng · 2024

Background Our previous studies have demonstrated that Raman spectroscopy could be used for skin cancer detection with good sensitivity and specificity. The objective of this study is to determine if skin cancer detection can be further im…

Single source CARS-based multimodal microscopy system for biological tissue imaging [Invited] Open

Ming-Yu Sheng, Yuan Zhao, Zhenguo Wu, Jianhua Zhao, Harvey Lui , et al. · 2023

A coherent anti-Stokes Raman scattering (CARS)-based multimodality microscopy system was developed using a single Ti:sapphire femtosecond laser source for biological imaging. It provides three complementary and co-registered imaging modali…

1117P Overall survival (OS) in patients with metastatic BRAF V600-mutant melanoma treated with encorafenib plus binimetinib (ENCO+BINI): Comparing real-world vs clinical trial data Open

G.K. In, Ken Chen, Gautam Sajeev, Ross J. Simpson, Sunil Kalia , et al. · 2023

Baseline Characteristics of Canadian Patients in the Psoriasis Longitudinal Assessment and Registry (PSOLAR) Open

Melinda Gooderham, Robert Bissonnette, Sunil Kalia, Kim Papp, Lyn Guenther , et al. · 2023

Background The Psoriasis Longitudinal Assessment and Registry (PSOLAR) is a global, prospective, longitudinal, disease-based registry. It serves as a post-marketing safety commitment with a focus on patients with moderate to severe plaque …

Tailored Sun Safety Messages for Outdoor Workers Open

Sajjad S Fazel, Shelby Fenton, Nicole Braun, Lindsay Forsman-Phillips, D. Linn Holness , et al. · 2023

The resulting tailored messages are a set of evidence-based, expert- approved, and stakeholder-workshopped messages that can be used in a variety of work settings as part of an exposure control plan for employers with outdoor workers.

Tralokinumab Plus Topical Corticosteroids as Needed Provides Progressive and Sustained Efficacy in Adults with Moderate-to-Severe Atopic Dermatitis Over a 32-Week Period: An ECZTRA 3 Post Hoc Analysis Open

Jonathan I. Silverberg, David N. Adam, Matthew Zirwas, Sunil Kalia, Jan Gutermuth , et al. · 2022

Validation of Medical Service Insurance Claims as a Surrogate for Ascertaining Vitiligo Cases Open

Madelaine Bell, Harvey Lui, Tim Lee, Sunil Kalia · 2022

Background: The epidemiology of vitiligo, especially its disease burden on the healthcare system, can be assessed indirectly by analyzing health insurance claims data. Validating this approach is integral to ensuring accurate case identifi…

Treatment Guidelines for Atopic Dermatitis Since the Approval of Dupilumab: A Systematic Review and Quality Appraisal Using AGREE-II Open

Stephanie Ghazal, Zainab Ridha, Kathleen D’Aguanno, David Nassim, Andrea Quaiattini , et al. · 2022

Introduction Since its approval for adults with moderate-to-severe atopic dermatitis (AD) in 2017, dupilumab has been incorporated into clinical practice guidelines (CPGs). However, recommendations differ internationally, and the quality a…

Incidence of skin cancers in patients with eczema treated with ultraviolet phototherapy Open

Tashmeeta Ahad, Elle Wang, Yi A. Liu, Tim K. Lee, Harvey Lui , et al. · 2021

Light and Laser-based Treatments for Hidradenitis Suppurativa: A Systematic Review Open

Ilya Mukovozov, Sara Mirali, Sofi Khaslavsky, Sunil Kalia · 2021

Background: Hidradenitis suppurativa (HS) is characterized by painful, recurrent lesions occurring mainly in intertriginous areas. The pain, odor, and disfigurement caused by HS significantly impacts quality of life and is challenging to t…

P-341 Sun exposure in outdoor workers: key considerations for an occupational surveillance system Open

Nicole Slot, Lindsay Forsman-Phillips, Victoria H Arrandale, Sunil Kalia, Thomas Tenkate , et al. · 2021

Introduction Outdoor workers are exposed to a variety of hazards, including solar ultraviolet radiation (UVR). Identifying, reporting, analyzing, and tracking the exposures or health outcomes of outdoor workers specifically have not genera…

O-277 Solar UVR exposure among outdoor workers in Alberta: Measurements and protective behaviours Open

Cheryl Peters, Ela Rydz, Andrew Harper, Brandon Leong, Victoria H Arrandale , et al. · 2021

Introduction Workplace solar UVR exposure has significant health and economic impacts. However, occupational exposure and sun protection behaviour data are scarcely available. Objectives This study aimed to characterize outdoor workers' fu…

Restructuring the workday to reduce occupational exposure to solar ultraviolet radiation (UVR) Open

Cheryl Peters, Thomas Tenkate, Emily Heer, Rachel O’Reilly, Sunil Kalia , et al. · 2021

BACKGROUND AND AIM: Messaging about sun avoidance strategies is often not practical for outdoor workers. The objective of this study was to use personal monitoring data to determine when peak UVR exposure occurs for outdoor workers, estima…

Constructing a portable optical polarimetry probe for in-vivo skin cancer detection Open

Daniel C. Louie, Lioudmila Tchvialeva, Sunil Kalia, Harvey Lui, Tim K. Lee · 2021

Tests of each probe component, and the complete system put together, were performed to evaluate error and confirm the probe's performance despite its low-cost components. This probe's potential is demonstrated in a pilot clinical study on …

Pregnancy Outcomes in Women With Moderate-to-Severe Psoriasis From the Psoriasis Longitudinal Assessment and Registry (PSOLAR) Open

Alexa B. Kimball, Lyn Guenther, Sunil Kalia, E.M.G.J. de Jong, Kimberly Parnell Lafferty , et al. · 2021

The findings of this cohort study suggest that pregnancy outcomes in PSOLAR have remained consistent with previous reports. Overall and live birth outcomes were similar to those for the general population.

Strategic Task and Break Timing to Reduce Ultraviolet Radiation Exposure in Outdoor Workers Open

Cheryl Peters, Thomas Tenkate, Emily Heer, Rachel O’Reilly, Sunil Kalia , et al. · 2020

Objectives: Public health messaging about sun avoidance strategies is often not practical for outdoor workers. The objective of this study was to use personal monitoring data to determine when peak UVR exposure occurs for outdoor wo…

Incorporating patient demographics into Raman spectroscopy algorithm improves in vivo skin cancer diagnostic specificity Open

Jianhua Zhao, Haishan Zeng, Sunil Kalia, Harvey Lui · 2019

The study objective is to evaluate whether incorporating patient demographics into Raman spectral analysis can improve diagnostic performance. In vivo Raman spectra of 731 cases were analyzed by dividing the data into two groups: skin canc…

Labial Melanotic Macules in Atopic Dermatitis: An Observational Study Open

Joseph M. Lam, MohammedI AlJasser, Harvey Lui, Sunil Kalia · 2019

Background: Labial melanotic macules (LMMs) are benign hyperpigmented macules of unknown etiology. They can affect one or both lips. Their description in patients with atopic dermatitis (AD) is limited in the published literature. Objectiv…

The Centre of Excellence in Cancer Prevention Archive of Website Blog Posts (October 2013 to October 2018) Open

Carolyn Gotay, Joan L. Bottorff, Kristin L. Campbell, Laura C. Dale, Sarah Neil‐Sztramko , et al. · 2019

The Centre of Excellence in Cancer Prevention Blog was a web-based resource that was published online for five years (October 2013 through October 2018). The blog provided a regular source of accessible, evidence-based and current informat…

Degree of optical polarization as a tool for detecting melanoma: proof of principle Open

Daniel C. Louie, Jamie Phillips, Lioudmila Tchvialeva, Sunil Kalia, Harvey Lui , et al. · 2018

Determining the optical polarization properties of a skin lesion is a proposed method to differentiate melanoma from other skin lesions. We developed an in vivo Stokes polarimetry probe that fires a laser of known polarization at the skin …

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