Sunil Kumar Dogga
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View article: Pf Atlas of sexual development
Pf Atlas of sexual development Open
The datasets here are a key addition to the Malaria Cell Atlas, that include short and long read single cell RNA-sequencing profiles of i) over 37,000 Plasmodium falciparum cells across intraerythrocytic asexual and sexual development of l…
View article: Pf Atlas of sexual development
Pf Atlas of sexual development Open
The datasets here are a key addition to the Malaria Cell Atlas, that include short and long read single cell RNA-sequencing profiles of i) over 37,000 Plasmodium falciparum cells across intraerythrocytic asexual and sexual development of l…
View article: Pf Atlas of sexual development
Pf Atlas of sexual development Open
The datasets here are a key addition to the Malaria Cell Atlas, that include short and long read single cell RNA-sequencing profiles of i) over 37,000 Plasmodium falciparum cells across intraerythrocytic asexual and sexual development of l…
View article: Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum
Novel insights into the role of long non-coding RNA in the human malaria parasite, Plasmodium falciparum Open
The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. Increasing evidence now suggests a major role for epigenetic mechanisms in gene …
View article: A single cell atlas of sexual development in<i>Plasmodium falciparum</i>
A single cell atlas of sexual development in<i>Plasmodium falciparum</i> Open
The developmental decision made by malaria parasites to become sexual underlies all malaria transmission. Here, we describe a rich atlas of short and long-read single-cell transcriptomes of over 37,000 Plasmodium falciparum cells across in…
View article: Pf Atlas of sexual development
Pf Atlas of sexual development Open
The datasets here are a key addition to the Malaria Cell Atlas, that include short and long read single cell RNA-sequencing profiles of i) over 37,000 Plasmodium falciparum cells across intraerythrocytic asexual and sexual development of l…
View article: Pf Atlas of sexual development
Pf Atlas of sexual development Open
The datasets here are a key addition to the Malaria Cell Atlas, that include short and long read single cell RNA-sequencing profiles of i) over 37,000 Plasmodium falciparum cells across intraerythrocytic asexual and sexual development of l…
View article: Isolating Plasmodium sexual and asexual parasites from malaria infected individuals for single cell RNA sequencing v1
Isolating Plasmodium sexual and asexual parasites from malaria infected individuals for single cell RNA sequencing v1 Open
This protocol isolates circulating sexual and asexual Plasmodium parasites from an infected individual's blood such that the resulting parasites are viable for single cell RNA sequencing, as well as bulk RNA sequencing and genome sequencin…
View article: Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite
Deciphering the non-coding code of pathogenicity and sexual differentiation in the human malaria parasite Open
The complex life cycle of Plasmodium falciparum requires coordinated gene expression regulation to allow host cell invasion, transmission, and immune evasion. However, this cascade of transcripts is unlikely to be regulated by the limited …
View article: Importance of aspartyl protease 5 in the establishment of the intracellular niche during acute and chronic infection of <i>Toxoplasma gondii</i>
Importance of aspartyl protease 5 in the establishment of the intracellular niche during acute and chronic infection of <i>Toxoplasma gondii</i> Open
Virulence and persistence of the obligate intracellular parasite Toxoplasma gondii involve the secretion of effector proteins belonging to the family of dense granule proteins (GRAs) that act notably as modulators of the host defense mecha…
View article: Tackling malaria transmission at a single cell level in an endemic setting in sub-Saharan Africa
Tackling malaria transmission at a single cell level in an endemic setting in sub-Saharan Africa Open
International audience
View article: Genomic reconstruction of the SARS-CoV-2 epidemic in England
Genomic reconstruction of the SARS-CoV-2 epidemic in England Open
The evolution of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus leads to new variants that warrant timely epidemiological characterization. Here we use the dense genomic surveillance data generated by the COVID-19 G…
View article: A single-cell atlas of <i>Plasmodium falciparum</i> transmission through the mosquito
A single-cell atlas of <i>Plasmodium falciparum</i> transmission through the mosquito Open
Malaria parasites have a complex life cycle featuring diverse developmental strategies, each uniquely adapted to navigate specific host environments. Here we use single-cell transcriptomics to illuminate gene usage across the transmission …
View article: Two palmitoyl acyltransferases involved sequentially in the biogenesis of the inner membrane complex of<i>Toxoplasma gondii</i>
Two palmitoyl acyltransferases involved sequentially in the biogenesis of the inner membrane complex of<i>Toxoplasma gondii</i> Open
The phylum Apicomplexa includes a number of significant human pathogens like Toxoplasma gondii and Plasmodium species. These obligate intracellular parasites possess a membranous structure, the inner membrane complex (IMC), composed of fla…
View article: Additional file 6 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 6 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 6 : Table S2. ΔACL/iΔACS acetytlome. Excel spreadheet summarising the acetylome data set from the nanoLC-MS/MS analysis. Sites and proteins which are significantly hypo- or hyper-acetylated in ΔACL/iΔACS parasites are highl…
View article: Additional file 10 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 10 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 10 : Table S5. ΔACL/iΔACS proteome. Excel spreadheet summarising the proteome data set from the nano-LC-MS/MS analysis. Proteins which are significantly up- or downregulated in ΔACL/iΔACS parasites are highlighted. Abbrevia…
View article: Additional file 11 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 11 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 11 : Table S6. ΔBCKDH transcriptome. Excel spreadheet summarising the transcriptome data set from the RNA-seq analysis. Transcripts which are significantly up- or downregulated in ΔBCKDH parasites are highlighted. Abbreviat…
View article: Additional file 14 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 14 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 14 : Table S8. Primers. Excel spreadsheet providing an overview of the primers used in this publication including their sequences.
View article: Additional file 12 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 12 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 12 : Table S7. ΔBCKDH proteome. Excel spreadheet summarising the proteome data set from the nano-LC-MS/MS analysis. Proteins which are significantly up- or downregulated in ΔBCKDH parasites are highlighted. Abbreviations: B…
View article: Additional file 2 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 2 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 2 : Table S1. ΔACL/iΔACS metabolome. Excel spreadheet summarising the metabolomic data set from the LC-MS analysis. Metabolites which are significantly decreased or increased in ΔACL parasites, iΔACS parasites and ΔACL/iΔAC…
View article: Additional file 7 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 7 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 7 : Table S3. ΔBCKDH acetytlome. Excel spreadheet summarising the acetylome data set from the nanoLC-MS/MS analysis. Sites and proteins which are significantly hypo- or hyper-acetylated in ΔBCKDH parasites are highlighted. …
View article: Additional file 9 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii
Additional file 9 of Multi-omics analysis delineates the distinct functions of sub-cellular acetyl-CoA pools in Toxoplasma gondii Open
Additional file 9 : Table S4. ΔACL/iΔACS transcriptome. Excel spreadheet summarising the transcriptome data set from the RNA-seq analysis. Transcripts which are significantly up- or downregulated in ΔACL/iΔACS parasites are highlighted. Ab…
View article: Transcriptome analysis of<i>Plasmodium berghei</i>during exo-erythrocytic development
Transcriptome analysis of<i>Plasmodium berghei</i>during exo-erythrocytic development Open
Summary The complex life cycle of malaria parasites requires well-orchestrated stage specific gene expression. In the vertebrate host the parasites grow and multiply by schizogony in two different environments: within erythrocytes and with…
View article: MOESM1 of Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development
MOESM1 of Transcriptome analysis of Plasmodium berghei during exo-erythrocytic development Open
Additional file 1: Table S1. RNA-seq data of different life cycle stages of P. berghei used in this study. Table S2. RNA-seq analysis: Raw sequencing counts per gene in the different life cycle stages. Table S3. Gene ontology (GO) term ann…
View article: <i>Toxoplasma gondii</i> TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis
<i>Toxoplasma gondii</i> TFP1 is an essential transporter family protein critical for microneme maturation and exocytosis Open
Summary Invasion and egress are two key steps in the lytic cycle of Apicomplexa that are governed by the sequential discharge of proteins from two apical secretory organelles called micronemes and rhoptries. In Toxoplasma gondii , the biog…