Sunil Sharma
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View article: CTNI-10. A PHASE 1/2 TRIAL OF FOG-001, A FIRST-IN-CLASS DIRECT β-CATENIN:TCF4 INHIBITOR: SAFETY AND PRELIMINARY ANTITUMOR ACTIVITY IN ADAMANTINOMATOUS CRANIOPHARYNGIOMA (ACP) PATIENTS
CTNI-10. A PHASE 1/2 TRIAL OF FOG-001, A FIRST-IN-CLASS DIRECT β-CATENIN:TCF4 INHIBITOR: SAFETY AND PRELIMINARY ANTITUMOR ACTIVITY IN ADAMANTINOMATOUS CRANIOPHARYNGIOMA (ACP) PATIENTS Open
BACKGROUND ACPs are brain tumors that typically originate in the suprasellar region and are associated with significant morbidity, with patients experiencing visual impairment, pituitary dysfunction and headaches. No systemic therapies are…
View article: NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer
NK cell-derived extracellular vesicles enhance cytotoxicity and immune cell recruitment in non-small cell lung cancer Open
Introduction Immune-based agents, especially Immune Checkpoint Inhibitors (ICI), are standard of care therapy in non-small cell lung cancers (NSCLC); however, a significant number of patient tumors fail to respond, or develop resistance. W…
View article: A Randomized Phase II Trial of Gemcitabine, Nab-Paclitaxel, Cisplatin with or without a Medically Supervised Ketogenic Diet for Patients with Metastatic Pancreatic Cancer
A Randomized Phase II Trial of Gemcitabine, Nab-Paclitaxel, Cisplatin with or without a Medically Supervised Ketogenic Diet for Patients with Metastatic Pancreatic Cancer Open
SUMMARY Background In this Phase II randomized clinical trial, we evaluated a medically supervised ketogenic diet (MSKD) compared to a usual diet (non-MSKD) when combined with the triplet chemotherapy regimen of gemcitabine, nab-paclitaxel…
View article: Performance analysis of Indian private sector banks: insights from CAMELS and statistical technique
Performance analysis of Indian private sector banks: insights from CAMELS and statistical technique Open
The performance of banks is crucial for a country’s economic development as they serve as important financial intermediaries. This study aims to evaluate the performance of private sector banks in India using the CAMELS model. The CAMELS m…
View article: Study on the Self-Assembly and Dual-Stimuli-Responsive Behavior of Multi-amphiphilic Polymeric Architectures
Study on the Self-Assembly and Dual-Stimuli-Responsive Behavior of Multi-amphiphilic Polymeric Architectures Open
View article: A study to evaluate the effectiveness of structured teaching programme on knowledge regarding varicose veins and its prevention among operation theatre and intensive care unit nurses of selected hospital at Jaipur
A study to evaluate the effectiveness of structured teaching programme on knowledge regarding varicose veins and its prevention among operation theatre and intensive care unit nurses of selected hospital at Jaipur Open
View article: 682 Ongoing phase 1/2 trial of the HPK1 inhibitor NDI-101150 as monotherapy and in combination with pembrolizumab: clinical safety update and renal cell carcinoma (RCC) efficacy analysis
682 Ongoing phase 1/2 trial of the HPK1 inhibitor NDI-101150 as monotherapy and in combination with pembrolizumab: clinical safety update and renal cell carcinoma (RCC) efficacy analysis Open
View article: 744 Phase 1b/2, multicenter dose escalation and expansion study of muzastotug (ADG126, a masked anti-CTLA-4 SAFEbody®) in combination with pembrolizumab in advanced/metastatic MSS CRC
744 Phase 1b/2, multicenter dose escalation and expansion study of muzastotug (ADG126, a masked anti-CTLA-4 SAFEbody®) in combination with pembrolizumab in advanced/metastatic MSS CRC Open
View article: Optimizing laser metal implantation through customized mayfly-integrative feed-forward neural network based clad property assessment
Optimizing laser metal implantation through customized mayfly-integrative feed-forward neural network based clad property assessment Open
Optimizing laser metal implantation is a multidisciplinary strategy that aims to improve the precision and efficiency of implanting metallic elements into the surface of a material by utilizing a laser. Cladding improves qualities by layer…
View article: Polatuzumab vedotin, venetoclax, and an <scp>anti‐CD20</scp> monoclonal antibody in relapsed/refractory B‐cell <scp>non‐Hodgkin</scp> lymphoma
Polatuzumab vedotin, venetoclax, and an <span>anti‐CD20</span> monoclonal antibody in relapsed/refractory B‐cell <span>non‐Hodgkin</span> lymphoma Open
The Phase 2 portion of this study evaluated safety and efficacy of polatuzumab vedotin 1.8 mg/kg and venetoclax 800 mg, plus fixed‐dose obinutuzumab 1000 mg or rituximab 375 mg/m 2 in patients with relapsed/refractory (R/R) follicular lymp…
View article: Phishing Emails Detection in Cyber Security
Phishing Emails Detection in Cyber Security Open
As digital communication becomes increasingly integral to personal and corporate activities, phishing attacks have emerged as a prevalent threat, ingeniously mimicking legitimate sources to illicitly acquire sensitive information. This res…
View article: Naturopathy: The Body’s Natural Power to Fight Pathogens
Naturopathy: The Body’s Natural Power to Fight Pathogens Open
Since ancient times, phase therapy or naturopathy is proving effective in all kinds of diseases. We should make maximum use of natural methods so that the cost of medical treatment in the world can be reduced and treatment can be easily ac…
View article: Efficient Synthesis and In-Silico Studies of Pyrano[3,2-C]Pyrones Based Glycohybrids
Efficient Synthesis and In-Silico Studies of Pyrano[3,2-C]Pyrones Based Glycohybrids Open
View article: Stimuli-Responsive Azo-Functionalized Non-Ionic Amphiphiles for Controlled Drug Delivery Applications
Stimuli-Responsive Azo-Functionalized Non-Ionic Amphiphiles for Controlled Drug Delivery Applications Open
View article: Thurston syndrome in two Indian female siblings
Thurston syndrome in two Indian female siblings Open
Thurston syndrome (oral-facial-digital syndromes [OFDS] Type V) is characterized by median cleft lip, postaxial polydactyly of hands and feet, and other oral manifestations. It is one of the OFDS described earlier in the literature. It is …
View article: A Critical Analysis of Kushthaghna Dravyas Mentioned in Sushrutokta Gana with Commentators View on Controversial Drugs
A Critical Analysis of Kushthaghna Dravyas Mentioned in Sushrutokta Gana with Commentators View on Controversial Drugs Open
Ayurveda is one of the oldest medical systems with a holistic approach to health and individualize medicine. All the skin diseases in Ayurveda have been discussed under the broad heading of Kushtha. The literal meaning of Kustha is “Kushna…
View article: 897-G SR-8541A, a small molecule inhibitor of ENPP1, enhances the effect of immune checkpoint inhibitors in a colorectal cancer model
897-G SR-8541A, a small molecule inhibitor of ENPP1, enhances the effect of immune checkpoint inhibitors in a colorectal cancer model Open
Background The five-year survival rate for colorectal cancer (CRC) remains at 14% despite improvements in early detection and development of novel treatments, including immune checkpoint inhibitors (ICIs). The immune landscape of CRC is he…
View article: Leveraging immunoliposomes as nanocarriers against SARS-CoV-2 and its emerging variants
Leveraging immunoliposomes as nanocarriers against SARS-CoV-2 and its emerging variants Open
The global COVID-19 pandemic arising from SARS-CoV-2 has impacted many lives, gaining interest worldwide ever since it was first identified in December 2019. Till 2023, 752 million cumulative cases and 6.8 million deaths were documented gl…
View article: Corrigendum to “Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial” [J Infect 84(6) (2022) 795–813, 5511]
Corrigendum to “Persistence of immunogenicity after seven COVID-19 vaccines given as third dose boosters following two doses of ChAdOx1 nCov-19 or BNT162b2 in the UK: Three month analyses of the COV-BOOST trial” [J Infect 84(6) (2022) 795–813, 5511] Open
View article: Supplementary Figure 4 from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response
Supplementary Figure 4 from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response Open
GSK-LSD1, Doxorubicin and AraC have no effect on KDM1A and KDM1B expression
View article: Data from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma
Data from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma Open
Histone deacetylase (HDAC) inhibition has sporadic clinical efficacy in urothelial carcinoma; the genomic basis for clinical response is not known. In two separate phase I clinical trials testing pharmacokinetic aspects of HDAC inhibitors …
View article: Supplemental Table 1 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma
Supplemental Table 1 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma Open
Demographic and clinical characteristics of patients treated with belinostat and panobinostat with archived tumor tissue available for study.
View article: Supplemental Figure 3 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma
Supplemental Figure 3 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma Open
Heat map of top 50 genes affected in HT1197 cells when treated with panobinostat at 48 hours log2 gene expression change(HT1197 A-B and C represent control replicates, HT1197 Pano A, B, C represent treated replicates). For the cell lines w…
View article: Data from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response
Data from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response Open
Multi-agent chemotherapeutic regimes remain the cornerstone treatment for Ewing sarcoma, the second most common bone malignancy diagnosed in pediatric and young adolescent populations. We have reached a therapeutic ceiling with conventiona…
View article: Supplementary Data from First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma
Supplementary Data from First-in-Human Phase I Study of Fisogatinib (BLU-554) Validates Aberrant FGF19 Signaling as a Driver Event in Hepatocellular Carcinoma Open
Supplement
View article: Supplemental figure 4 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma
Supplemental figure 4 from Histone Deacetylase Inhibition Has Targeted Clinical Benefit in <i>ARID1A</i>-Mutated Advanced Urothelial Carcinoma Open
GSEA with Hallmark gene sets performed on transcriptional changes in HT1197 cells treated with panobinostat for 48 hours. A. Top 6 downregulated GSEA signatures B. Top 6 upregulated GSEA signatures C. GSEA HT1197 vs UMUC3 ( comparison of t…
View article: Supplementary Figure 2 from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response
Supplementary Figure 2 from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response Open
Targeted KDM1A inhibition and EWS/FLI knockdown induces similar transcriptional signatures
View article: Supplementary Figure Legend from Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
Supplementary Figure Legend from Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells Open
PDF - 95K, Figure legends for the Supplemental Data.
View article: Supplementary Figure Legend from Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells
Supplementary Figure Legend from Highly Active Combination of BRD4 Antagonist and Histone Deacetylase Inhibitor against Human Acute Myelogenous Leukemia Cells Open
PDF - 95K, Figure legends for the Supplemental Data.
View article: Data from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response
Data from Therapeutic Targeting of KDM1A/LSD1 in Ewing Sarcoma with SP-2509 Engages the Endoplasmic Reticulum Stress Response Open
Multi-agent chemotherapeutic regimes remain the cornerstone treatment for Ewing sarcoma, the second most common bone malignancy diagnosed in pediatric and young adolescent populations. We have reached a therapeutic ceiling with conventiona…