Explanipedia

Loss of synovial tissue macrophage homeostasis precedes rheumatoid arthritis clinical onset Open

Megan M. Hanlon, Conor M. Smith, Mary Canavan, Nuno Neto, Qingxuan Song , et al. · 2024

This study performed an in-depth investigation into the myeloid cellular landscape in the synovium of patients with rheumatoid arthritis (RA), “individuals at risk” of RA, and healthy controls (HC). Flow cytometric analysis demonstrated th…

Environmental insults and compensative responses: when microbiome meets cancer Open

Sunil Nagpal, Sharmila S. Mande · 2023

Tumor microenvironment has recently been ascribed a new hallmark—the polymorphic microbiome. Accumulating evidence regarding the tissue specific territories of tumor-microbiome have opened new and interesting avenues. A pertinent question …

Transcriptomic profiling of programmed cell death 1 (PD-1) expressing T cells in early rheumatoid arthritis identifies a decreased CD4 + PD-1 + signature post-treatment Open

Katie Lowe, Annabelle Small, Qingxuan Song, Ling‐Yang Hao, William Murray‐Brown , et al. · 2023

Environmental insults and compensative responses: when microbiome meets cancer Open

Sunil Nagpal, Sharmila S. Mande · 2023

Tumor microenvironment has recently been ascribed a new hallmark – the polymorphic microbiome. Accumulating evidence regarding the tissue specific territories of tumor-microbiome have opened new and interesting avenues. A pertinent questio…

Rheumatoid arthritis macrophages are primed for inflammation and display bioenergetic and functional alterations Open

Megan M. Hanlon, Trudy McGarry, Viviana Marzaioli, Success Amaechi, Qingxuan Song , et al. · 2022

Objectives Myeloid cells with a monocyte/macrophage phenotype are present in large numbers in the RA joint, significantly contributing to disease; however, distinct macrophage functions have yet to be elucidated. This study investigates th…

Differential expansion of T peripheral helper cells in early rheumatoid arthritis and osteoarthritis synovium Open

William Murray‐Brown, Yanxia Guo, Annabelle Small, Katie Lowe, Helen Weedon , et al. · 2022

Objectives Programmed cell death protein 1 (PD-1)-expressing T cells are implicated in the pathogenesis of autoimmune inflammatory diseases such as rheumatoid arthritis. A subset of CXCR5 − T cells, termed T peripheral helper (Tph) cells, …

OP0013 LOSS OF SYNOVIAL TISSUE MACROPHAGE HOMEOSTASIS PRECEDES RHEUMATOID ARTHRITIS CLINICAL ONSET Open

M. Hanlon, Mary Canavan, Nuno Neto, Qingxuan Song, P. Gallagher , et al. · 2022

Attenuation of the BTLA/HVEM Regulatory Network in the Circulation in Primary Sjögren’s Syndrome Open

Annabelle Small, Suzanne Cole, Jing Jing Wang, Sunil Nagpal, Ling‐Yang Hao , et al. · 2022

Primary Sjögren’s syndrome (SjS) is an inflammatory autoimmune disorder which targets the lacrimal and salivary glands, resulting in glandular dysfunction. Currently, the immune drivers of SjS remain poorly understood and peripheral biomar…

Functionally Mature CD1c+ Dendritic Cells Preferentially Accumulate in the Inflammatory Arthritis Synovium Open

Mary Canavan, Viviana Marzaioli, Vipul Bhargava, Sunil Nagpal, Phil Gallagher , et al. · 2021

Objective To examine the role of synovial CD1c + DCs in patients with Inflammatory Arthritis (IA) with a specific focus on the transcriptional and maturation signatures that govern their function. Methods RNA sequencing was performed on he…

POS0387 ACPA STATUS CORRELATES WITH DIFFERENTIAL IMMUNE PROFILE OF RHEUMATOID ARTHRITIS PATIENTS Open

Achilleas Floudas, Mary Canavan, Trudy McGarry, Vinod Krishna, Sunil Nagpal , et al. · 2021

ACPA Status Correlates with Differential Immune Profile in Patients with Rheumatoid Arthritis Open

Achilleas Floudas, Mary Canavan, Trudy McGarry, Ronan Mullan, Sunil Nagpal , et al. · 2021

Rheumatoid arthritis (RA) is a progressive erosive autoimmune disease that affects 1% of the world population. Anti-citrullinated protein autoantibodies (ACPA) are routinely used for the diagnosis of RA, however 20–30% of patients are ACPA…

Rheumatoid arthritis CD14<sup>+</sup> monocytes display metabolic and inflammatory dysfunction, a phenotype that precedes clinical manifestation of disease Open

Trudy McGarry, Megan M. Hanlon, Viviana Marzaioli, Clare C. Cunningham, Vinod Krishna , et al. · 2021

Introduction This study investigates the metabolic activity of circulating monocytes and their impact on pro‐inflammatory responses in RA and explores whether this phenotype is already primed for inflammation before clinical manifestations…

Integration of the Transcriptome and Genome-Wide Landscape of BRD2 and BRD4 Binding Motifs Identifies Key Superenhancer Genes and Reveals the Mechanism of Bet Inhibitor Action in Rheumatoid Arthritis Synovial Fibroblasts Open

Vinod Krishna, Xuefeng Yin, Qingxuan Song, Alice M. Walsh, David Pocalyko , et al. · 2020

Fibroblast-like synoviocytes (FLS), one of the main cell types of the rheumatoid arthritis (RA) synovium, possess phenotypic and molecular characteristics of transformed cells. JQ1, an inhibitor of the bromodomain and extra terminal domain…

Pathogenic, glycolytic PD-1+ B cells accumulate in the hypoxic RA joint Open

Achilleas Floudas, Nuno Neto, Viviana Marzaioli, Kieran Murray, Barry Moran , et al. · 2020

While autoantibodies are used in the diagnosis of rheumatoid arthritis (RA), the function of B cells in the inflamed joint remains elusive. Extensive flow cytometric characterization and SPICE algorithm analyses of single-cell synovial tis…

Rheumatoid arthritis synovial microenvironment induces metabolic and functional adaptations in dendritic cells Open

Mary Canavan, Viviana Marzaioli, Trudy McGarry, Vipul Bhargava, Sunil Nagpal , et al. · 2020

Summary Rheumatoid arthritis (RA) is a chronic autoimmune disease which causes degradation of cartilage and bone. It is well appreciated that the pathogenic hallmark of RA is the mass influx of inflammatory cells into the joint. However, t…

AB0037 EXPRESSION OF NEGATIVE CHECKPOINT MOLECULES BTLA AND HVEM IS DYSREGULATED IN AUTOIMMUNE DISEASES Open

Sunil Nagpal, Suzanne Cole, Achilleas Floudas, Mihir D. Wechalekar, Qingxiao Song , et al. · 2020

OP0337 DIFFERENTIAL METHYLATION OF PERIPHERAL BLOOD ADAPTIVE IMMUNE CELLS IN INDIVIDUALS AT HIGH RISK FOR RA AND WITH EARLY RA COMPARED WITH CONTROLS IDENTIFIES PATHWAYS IMPORTANT IN TRANSITION TO ARTHRITIS Open

Rizi Ai, D. Boyle, Deepa Hammaker, Kevin D. Deane, V. Michael Holers , et al. · 2020

THU0033 ALTERATIONS IN THE PHENOTYPIC LANDSCAPE AND SPECIFICITY OF CD4+ T CELLS IN CCP+ AT RISK SUBJECTS BEFORE THE ONSET OF RHEUMATOID ARTHRITIS Open

Cliff Rims, Virginia Muir, Kevin D. Deane, Sunil Nagpal, Navin Rao , et al. · 2020

SAT0003 ELEVATED BASELINE AND INCREASING AUTOANTIBODY LEVELS ARE ASSOCIATED WITH INCREASED RISK FOR IMMINENT ONSET OF INFLAMMATORY ARTHRITIS IN A PROSPECTIVELY STUDIED ANTI-CITRULLINATED PROTEIN ANTIBODY POSITIVE COHORT: THE TIP-RA COLLECTIVE Open

Kevin D. Deane, Gary S. Firestein, D. Boyle, Jane H. Buckner, Eddie A. James , et al. · 2020

Cohort profile of a US military population for evaluating pre-disease and disease serological biomarkers in rheumatoid and reactive arthritis: Rationale, organization, design, and baseline characteristics Open

Chad K. Porter, Mark S. Riddle, Renée M. Laird, Matthew J. Loza, Suzanne Cole , et al. · 2020

This study establishes the framework for the evaluation of novel serum biomarkers enabling the identification of signals prior to clinical disease that may enable disease prediction, elucidate disease pathogenesis and identify novel exposu…

Discovery of <i>N</i>-(Indazol-3-yl)piperidine-4-carboxylic Acids as RORγt Allosteric Inhibitors for Autoimmune Diseases Open

Hongjun Zhang, Blair T. Lapointe, Neville J. Anthony, Rita Azevedo, Jos Cals , et al. · 2020

The clinical success of anti-IL-17 monoclonal antibodies (i.e., Cosentyx and Taltz) has validated Th17 pathway modulation for the treatment of autoimmune diseases. The nuclear hormone receptor RORγt is a master regulator of Th17 cells and …

SAT0082 ASSOCIATIONS OF BASELINE CLINICAL AND BIOMARKER FACTORS WITH SYMPTOMS AND FUTURE DEVELOPMENT OF CLINICALLY-APPARENT RHEUMATOID ARTHRITIS IN AN ACPA POSITIVE COHORT Open

Kevin D. Deane, Sunil Nagpal, Navin Rao, Frédéric Baribaud, George Vratsanos , et al. · 2019

OP0118 DISCRETE PATTERNS OF CITRULLINATED PEPTIDE AUTOANTIBODY REACTIVITIES EMERGE DURING PROGRESSION FROM PRE-DISEASE STATE TO DIAGNOSIS OF RHEUMATOID ARTHRITIS Open

Matthew J. Loza, Sunil Nagpal, Renée M. Laird, Suzanne Cole, Frédéric Baribaud , et al. · 2019

Enriched Cd141+ DCs in the joint are transcriptionally distinct, activated, and contribute to joint pathogenesis Open

Mary Canavan, Alice M. Walsh, Vipul Bhargava, S Wade, Trudy McGarry , et al. · 2018

CD141+ DC are implicated in antiviral and antitumor immunity. However, mechanistic studies in autoimmune disease are limited. This is the first study to our knowledge examining CD141+ DC in autoimmune disease, specifically inflammatory art…

Comprehensive epigenetic landscape of rheumatoid arthritis fibroblast-like synoviocytes Open

Rizi Ai, Teresina Laragione, Deepa Hammaker, David L. Boyle, André Wildberg , et al. · 2018

Integrative analysis reveals CD38 as a therapeutic target for plasma cell-rich pre-disease and established rheumatoid arthritis and systemic lupus erythematosus Open

Suzanne Cole, Alice M. Walsh, Xuefeng Yin, Mihir D. Wechalekar, Malcolm Smith , et al. · 2018

The Rheumatoid Arthritis-Associated Citrullinome Open

Ronak Tilvawala, Son Hong Nguyen, Aaron Maurais, Venkatesh V. Nemmara, Mitesh Nagar , et al. · 2018

Immune checkpoint inhibitor PD-1 pathway is down-regulated in synovium at various stages of rheumatoid arthritis disease progression Open

Yanxia Guo, Alice M. Walsh, Mary Canavan, Mihir D. Wechalekar, Suzanne Cole , et al. · 2018

Immune checkpoint blockade with therapeutic anti-cytotoxic T lymphocyte-associated antigen (CTLA)-4 (Ipilimumab) and anti-programmed death (PD)-1 (Nivolumab and Pembrolizumab) antibodies alone or in combination has shown remarkable efficac…

Triple DMARD treatment in early rheumatoid arthritis modulates synovial T cell activation and plasmablast/plasma cell differentiation pathways Open

Alice M. Walsh, Mihir D. Wechalekar, Yanxia Guo, Xuefeng Yin, Helen Weedon , et al. · 2017

We have identified transcriptomic signatures that characterize synovial tissue from RA patients with early disease. Analysis after 6 months of tDMARD treatment highlight consistent alterations in expression of genes related to T cell activ…

THU0011 Immune signal 2 checkpoint molecule expression in rheumatoid arthritis disease progression Open

AM Walsh, Mary Canavan, Yizhan Guo, Trudy McGarry, Xuefeng Yin , et al. · 2017

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