Pradipsinh K. Rathod
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View article: Understanding the Unmet Needs of People Living with Type 2 Diabetes in Self-Managing Their Condition
Understanding the Unmet Needs of People Living with Type 2 Diabetes in Self-Managing Their Condition Open
Background/Objectives: Type 2 diabetes (T2D) prevalence is rising worldwide. Despite numerous efforts to address the condition, many initiatives fall short due to limited consumer engagement. Involving people with lived experience in healt…
View article: Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention
Structure-Based Discovery and Development of Highly Potent Dihydroorotate Dehydrogenase Inhibitors for Malaria Chemoprevention Open
Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically validated as a target for treatment and prevention of malaria thro…
Descriptive, Hospital-Based, 10-Year Study of Malaria Transmission in Goa, a Southwest Indian State in the Malaria Elimination Phase Open
The South Asia International Center of Excellence for Malaria Research, an NIH-funded collaborative program, investigated the epidemiology of malaria in the Indian state of Goa through health facility–based data collected from the Goa Medi…
Low Genetic Diversity of Plasmodium vivax Circumsporozoite Surface Protein in Clinical Isolates from Southern Thailand Open
The genetic diversity within the circumsporozoite surface protein (PvCSP) of Plasmodium vivax, the predominant malaria species in Thailand, is primarily observed in the northwestern region along the Thailand–Myanmar border. However, as P. …
Tartrolon E, a secondary metabolite of a marine symbiotic bacterium, is a potent inhibitor of asexual and sexual <i>Plasmodium falciparum</i> Open
Due to the spread of resistance to front-line artemisinin derivatives worldwide, there is a need for new antimalarials. Tartrolon E (TrtE), a secondary metabolite of a symbiotic bacterium of marine bivalve mollusks, is a promising antimala…
Multiplex Assays for Analysis of Antibody Responses to South Asian Plasmodium falciparum and Plasmodium vivax Malaria Infections Open
Malaria remains a major global health challenge, causing over 0.6 million yearly deaths. To understand naturally acquired immunity in adult human populations in malaria-prevalent regions, improved serological tools are needed, particularly…
View article: Development of a<i>Plasmodium vivax</i>biobank for functional<i>ex vivo</i>assays
Development of a<i>Plasmodium vivax</i>biobank for functional<i>ex vivo</i>assays Open
Background Plasmodium vivax is the second most prevalent cause of malaria yet remains challenging to study due to the lack of a continuous in vitro culture system, highlighting the need to establish a biobank of clinical isolates with mult…
View article: Additional file 2 of Development of a Plasmodium vivax biobank for functional ex vivo assays
Additional file 2 of Development of a Plasmodium vivax biobank for functional ex vivo assays Open
Additional file 2. Data for figures 1–5.
View article: Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant <i>Acinetobacter baumannii</i>
Repurposed dihydroorotate dehydrogenase inhibitors with efficacy against drug-resistant <i>Acinetobacter baumannii</i> Open
New antimicrobials are needed for the treatment of extensively drug-resistant Acinetobacter baumannii . The de novo pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a validated drug target for malaria and human autoim…
International Center of Excellence for Malaria Research for South Asia and Broader Malaria Research in India Open
The Malaria Evolution in South Asia (MESA) International Center of Excellence for Malaria Research (ICEMR) conducted research studies at multiple sites in India to record blood-slide positivity over time, but also to study broader aspects …
Diverse Malaria Presentations across National Institutes of Health South Asia International Center for Excellence in Malaria Research Sites in India Open
The Malaria Evolution in South Asia (MESA) International Center for Excellence in Malaria Research (ICEMR) was established by the US National Institutes of Health (US NIH) as one of 10 malaria research centers in endemic countries. In 10 y…
Properties of Plasmodium falciparum with a Deleted Apicoplast DNA Gyrase Open
Malaria parasites have three genomes: a nuclear genome, a mitochondrial genome, and an apicoplast genome. Since the apicoplast is a plastid organelle of prokaryotic origin and has no counterpart in the human host, it can be a source of nov…
View article: Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series
Potent Antimalarials with Development Potential Identified by Structure-Guided Computational Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series Open
Dihydroorotate dehydrogenase (DHODH) has been clinically validated as a target for the development of new antimalarials. Experience with clinical candidate triazolopyrimidine DSM265 (1) suggested that DHODH inhibitors have great potential …
Extrachromosomal DNA amplicons in antimalarial‐resistant <i>Plasmodium falciparum</i> Open
Extrachromosomal (ec) DNAs are genetic elements that exist separately from the genome. Since ecDNA can carry beneficial genes, they are a powerful adaptive mechanism in cancers and many pathogens. For the first time, we report ecDNA contri…
<i>Plasmodium vivax</i> Strains Use Alternative Pathways for Invasion Open
Plasmodium vivax has 2 invasion ligand/host receptor pathways (P. vivax Duffy-binding protein/Duffy antigen receptor for chemokines [DARC] and P. vivax reticulocyte binding protein 2b/transferrin receptor [TfR1]) that are promising targets…
Plasmodium vivax infection compromises reticulocyte stability. Open
The structural integrity of the host red blood cell (RBC) must be maintained for propagation of Plasmodium spp. during the disease causing blood-stage of malaria infection. Plasmodium vivax infection is restricted to reticulocytes. To asse…
A symbiotic bacterium of shipworms produces a compound with broad spectrum anti-apicomplexan activity Open
Apicomplexan parasites cause severe disease in both humans and their domesticated animals. Since these parasites readily develop drug resistance, development of new, effective drugs to treat infection caused by these parasites is an ongoin…
View article: Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria
Lead Optimization of a Pyrrole-Based Dihydroorotate Dehydrogenase Inhibitor Series for the Treatment of Malaria Open
Malaria puts at risk nearly half the world's population and causes high mortality in sub-Saharan Africa, while drug resistance threatens current therapies. The pyrimidine biosynthetic enzyme dihydroorotate dehydrogenase (DHODH) is a valida…
A robust in vitro liver cell model for long-term study of Plasmodium vivax hypnozoites Open
Background Plasmodium vivax is the most prevalent species of human malaria parasites, affecting nearly half of the world’s population. Eradication of malaria is difficult because of the ability of hypnozoite, the dormant liver-stage form o…
Decreased <i>In Vitro</i> Artemisinin Sensitivity of <i>Plasmodium falciparum</i> across India Open
Artemisinin-based combination therapy (ACT) has been used to treat uncomplicated Plasmodium falciparum infections in India since 2004. Since 2008, a decrease in artemisinin effectiveness has been seen throughout the Greater Mekong Subregio…
Meta-analysis of Plasmodium falciparum <i>var</i> Signatures Contributing to Severe Malaria in African Children and Indian Adults Open
P. falciparum malaria can cause multiple disease complications that differ by patient age. Previous studies have attempted to address the roles of parasite adhesion and biomass in disease severity; however, these studies have been limited …
Hospital-derived antibody profiles of malaria patients in Southwest India Open
Seroreactivity at a major hospital in Southwest India reveals antibody responses to P. falciparum and P. vivax in a low malaria transmission region with much migration. In addition to markers of transmission, the data points to specific le…
MOESM2 of Hospital-derived antibody profiles of malaria patients in Southwest India Open
Additional file 2. Seroreactive P. falciparum and P. vivax antigens.
MOESM4 of Hospital-derived antibody profiles of malaria patients in Southwest India Open
Additional file 4. Details of cross-reactive P. falciparum and P. vivax antigens.
MOESM1 of Hospital-derived antibody profiles of malaria patients in Southwest India Open
Additional file 1. Patient data for parasite density, hospitalization status and severity.
MOESM7 of Hospital-derived antibody profiles of malaria patients in Southwest India Open
Additional file 7. Scatter plots for antibody breadth in patients.