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View article: STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis
STARD7 maintains intestinal epithelial mitochondria architecture, barrier integrity, and protection from colitis Open
Susceptibility to inflammatory bowel diseases (IBDs), Crohn's disease (CD), and ulcerative colitis (UC) is linked with loss of intestinal epithelial barrier integrity and mitochondria dysfunction. Steroidogenic acute regulatory (StAR) prot…
View article: Acute systemic myeloid inflammatory and stress response in severe food allergic reactions
Acute systemic myeloid inflammatory and stress response in severe food allergic reactions Open
Introduction Food allergic reactions can be severe and potentially life‐threatening and the underlying immunological processes that contribute to the severity of reactions are poorly understood. The aim of this study is to integrate bulk R…
View article: Intestinal epithelial BLT1 promotes mucosal repair
Intestinal epithelial BLT1 promotes mucosal repair Open
Acute and chronic intestinal inflammation is associated with epithelial damage, resulting in mucosal wounds in the forms of erosions and ulcers in the intestinal tract. Intestinal epithelial cells (IECs) and immune cells in the wound milie…
Metabolites in galls induced on the leaves of Trewian udiflora (L.) (Euphorbiaceae) by Trioza fletcheri Crawford (Hemiptera: Triozidae) Open
Trioza fletcheri Crawford is a sap-sucking psyllid that induces galls on Trewia nudiflora leaves. Early stages of T. fletcheri feed on parenchyma, whereas late-stages and adults feed on phloem, causing galls which arise in an isolated, agg…
Thermoneutrality Alters Gastrointestinal Antigen Passage Patterning and Predisposes to Oral Antigen Sensitization in Mice Open
Food allergy is an emerging epidemic, and the underlying mechanisms are not well defined partly due to the lack of robust adjuvant free experimental models of dietary antigen sensitization. As housing mice at thermoneutrality (Tn) - the te…
Recent advances in mechanisms of food allergy and anaphylaxis Open
Food allergens are innocuous proteins that promote tolerogenic adaptive immune responses in healthy individuals yet in other individuals induce an allergic adaptive immune response characterized by the presence of antigen-specific immunogl…
Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response Open
Diminished GATA-1 activity results in reduced in vitro mast cell FcεRIα expression, proliferation, and degranulation activity. However, in vivo, diminished GATA-1 activity results in normal homeostatic tissue mast cell levels and increased…
Functional characterization of a panel of high-grade serous ovarian cancer cell lines as representative experimental models of the disease Open
Genomic analysis of ovarian cancer cell lines has revealed a panel that best represents the most common ovarian cancer subtype, high-grade serous ovarian cancer (HGSOC). However, these HGSOC-like cell lines have not been extensively applie…