Explanipedia

Serum vascular endothelial growth factor in patients with nonmelanoma primary ocular malignancies: A possible potential biomarker of tumor progression and poor prognosis Open

Rajendra P Maurya, Anjali Singh, V. P. Singh, Sunit K. Singh, Raksha Rao , et al. · 2025

CONTEXT: Vascular endothelial growth factor (VEGF) is a potent and specific angiogenic growth factor that may participate in the formation of the vascular tumor stroma. Pretreatment VEGF levels can be a biomarker to predict tumor progressi…

Proteome profiling of human lung epithelial cells unveils distinct patterns of protein expression in response to SARS-CoV-2 ORF3a Open

Apoorva, Astha Shukla, Atul Kumar, Saurabh Pratap Singh, Sunit K. Singh · 2025

The COVID-19 pandemic caused by SARS-CoV-2 remains an ongoing global health concern. Understanding the roles of SARS-CoV-2 accessory proteins is essential for developing effective therapeutic strategies. We present a comprehensive proteomi…

Dengue virus NS1 hits hard at the barrier integrity of human cerebral microvascular endothelial cells via cellular microRNA dysregulations Open

Apoorva, Atul Kumar, Sunit K. Singh · 2024

Dengue virus (DENV) infections are commonly reported in the tropical and subtropical regions of the world. DENV is reported to exploit various strategies to cross the blood-brain barrier. The NS1 protein of DENV plays an important role in …

A tale of endurance: bats, viruses and immune dynamics Open

Apoorva, Sunit K. Singh · 2024

The emergence of highly zoonotic viral infections has propelled bat research forward. The viral outbreaks including Hendra virus, Nipah virus, Marburg virus, Ebola virus, Rabies virus, Middle East respiratory syndrome coronavirus, SARS-CoV…

Urban ambient PM10 analysis: Characterization, sources, health risk and sustainable solutions Open

Mayuri Patil, Asmita S. Jadhav, Sunit K. Singh, S. T. Ingle · 2024

This is the first inclusive research concerning PM10 samples collected from 3 cities of Maharashtra State of India which categorized into 9 microenvironments. This study presents insights to chemical and morphological analysis, health risk…

Determination and evaluation of HR-HPV genotype in different communities of Bihar, India. Open

Akhtar Parwez, Sunit K. Singh, Rahul Kumar, Roushan Kumari, V. Siva Kumar , et al. · 2022

Our study indicates that personal hygiene possibly reduces HPV infection in women and the evidence suggests that male circumcision has a protective role of HPV infection in Muslim community. Therefore, personal hygiene and circumcision may…

Oncogenic human papillomavirus DNA in female sex workers of Bihar, India. Open

Akhtar Parwez, Sunit K. Singh, Rahul Kumar, Sristy Kumari, Arun Kumar , et al. · 2022

The study indicates that oncogenic HPV prevalence did not different significantly in multiple sex partners, that is, FSWs and single sex partner, that is, MW. The probability of genital hygiene rather than multiple sexual partners stands m…

Chandipura virus dysregulates the expression of hsa-miR-21-5p to activate NF-κB in human microglial cells Open

Neha Pandey, Meghana Rastogi, Sunit K. Singh · 2021

Background Chandipura virus (CHPV) is a negative single-stranded RNA virus of the Rhabdoviridae family. CHPV infection has been reported in Central and Western India. CHPV causes acute encephalitis with a case fatality rate of 70 % and mos…

Why airborne transmission hasn't been conclusive in case of COVID-19? An atmospheric science perspective Open

Kirpa Ram, Roseline C. Thakur, Dharmendra Kumar Singh, Kimitaka Kawamura, Akito Shimouchi , et al. · 2021

Serum Malondialdehyde as a Biomarker of Oxidative Stress in Patients with Primary Ocular Carcinoma: Impact on Response to Chemotherapy Open

Rajendra P Maurya, Manish Prajapat, V. P. Singh, Meghna Roy, Ravina Todi , et al. · 2021

The serum MDA level is a potential biomarker in primary ocular carcinoma to assess oxidative stress and its impact on response to chemotherapy.

SARS coronavirus 2: from genome to infectome Open

Meghana Rastogi, Neha Pandey, Astha Shukla, Sunit K. Singh · 2020

Mitochondrial Stress–Mediated Targeting of Quiescent Cancer Stem Cells in Oral Squamous Cell Carcinoma Open

Shyamkumar TS, Vijay Kumar, Manish Agrawal, Anurag Tripathi, Meher RK , et al. · 2020

Tajindra Singh Saluja,1 Vijay Kumar,2 Monika Agrawal,3 Abhilasha Tripathi,4 Rajesh Kumar Meher,5 Kamini Srivastava,1 Anurag Gupta,1 Anjana Singh,6 Arun Chaturvedi,2 Satyendra Kumar Singh1 1Stem Cell/Cell Culture Unit, Center for Advance Re…

Will COVID-19 become the next neglected tropical disease? Open

Peter J. Hotez, María Elena Bottazzi, Sunit K. Singh, Paul J. Brindley, Shaden Kamhawi · 2020

Modulation of Type-I Interferon Response by hsa-miR-374b-5p During Japanese Encephalitis Virus Infection in Human Microglial Cells Open

Meghana Rastogi, Sunit K. Singh · 2019

Japanese Encephalitis virus (JEV) is a neurotropic ssRNA virus, belonging to the Flaviviridae family. JEV is one of the leading causes of the viral encephalitis in Southeast-Asian countries. JEV primarily infects neurons however, th…

Index Open

Sunit K. Singh · 2018

acyclovir 90-91 adhesion proteins chancroid 280-282 mycoplasmas 236 T. vaginalis 345 administration, vaginal probiotics 50 AIDS see human immunodeficiency virus AIRE mutation 302-304 amphotericin B 315 AMPs see antimicrobial peptides AMR s…

Middle East Respiratory Syndrome Virus Pathogenesis Open

Sunit K. Singh · 2016

Coronaviruses (CoVs) are enveloped RNA viruses that infect birds, mammals, and humans. Infections caused by human coronaviruses (hCoVs) are mostly associated with the respiratory, enteric, and nervous systems. The hCoVs only occasionally i…

Respiratory Viral Infections Open

Sunit K. Singh · 2016

Viral infections represent a major cause of respiratory tract infections globally. The incidences of viral infections are very high among infants and old age groups. The respiratory viral infections often may lead to complications such as …

Flavivirus NS1: a multifaceted enigmatic viral protein Open

Meghana Rastogi, Nikhil Sharma, Sunit K. Singh · 2016

Flaviviruses are emerging arthropod-borne viruses representing an immense global health problem. The prominent viruses of this group include dengue virus, yellow fever virus, Japanese encephalitis virus, West Nile virus tick borne encephal…

Japanese Encephalitis Virus exploits the microRNA-432 to regulate the expression of Suppressor of Cytokine Signaling (SOCS) 5 Open

Nikhil Sharma, Kanhaiya Lal Kumawat, Meghana Rastogi, Anirban Basu, Sunit K. Singh · 2016

Japanese encephalitis virus (JEV) is a plus strand RNA virus, which infects brain. MicroRNAs are regulatory non-coding RNAs which regulate the expression of various genes in cells. Viruses modulate the expression of various microRNAs to su…

Index Open

Sunit K. Singh · 2015

Note: Page numbers with suffix "f" refer to figures; those with suffix "t" to tables.ABPA, see allergic bronchopulmonary aspergillosis accessory sequences, 748 acellular vaccines, 654 acetaminophen, in DENV treatment, 136 acetoin and dihyd…

Color Plates Open

Sunit K. Singh · 2015

Mosquito Mosquito Humans Birds Pigs Fig. 6-2 Life cycle of Japanese encephalitis virus.JEV is maintained in a zoonotic cycle (black arrow) involving pigs, ardeid birds, and mosquitoes.Pigs are the major amplification/reservoir host, birds …

Index Open

Sunit K. Singh · 2015

HIV Tat protein: Is Tat‐C much trickier than Tat‐B? Open

Manish Kumar Johri, Nikhil Sharma, Sunit K. Singh · 2015

Out of various subtypes of human immunodeficiency virus type 1 (HIV‐1), subtype B and C cause most of the infections worldwide. Clade specific differences have been reported in differences in clinical picture of HIV pathogenesis. Transcrip…

miR-146a suppresses cellular immune response during Japanese encephalitis virus JaOArS982 strain infection in human microglial cells Open

Nikhil Sharma, Ruhi Verma, Kanhaiya Lal Kumawat, Anirban Basu, Sunit K. Singh · 2015

Upregulation of miR-146a by JEV JaOArS982 strain leads to suppression of NF-κB activity and disruption of antiviral Jak-STAT signaling which helps the virus to evade the cellular immune response. This effect of JEV infection on miR-146a ex…

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