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View article: Endothelial knockdown of the tumor suppressor, <i>WWOX</i> , increases inflammation in ventilator-induced lung injury
Endothelial knockdown of the tumor suppressor, <i>WWOX</i> , increases inflammation in ventilator-induced lung injury Open
Prior tobacco smoke exposure is associated with an increased risk of acute respiratory distress syndrome (ARDS) during critical illness. Our laboratory is investigating one of the gene expression changes that occurs in the lung following s…
View article: Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury
Endothelial Knockdown of the Tumor Suppressor, WWOX, Increases Inflammation in Ventilator-Induced Lung Injury Open
Background Chronic cigarette smoke exposure downregulates lung expression of WWOX, an ARDS relevant tumor suppressor. Prior work has revealed a barrier protective function of WWOX during infectious models of ARDS. Proteomic analysis of WWO…
View article: Design and rationale of the CHILL phase II trial of hypothermia and neuromuscular blockade for acute respiratory distress syndrome
Design and rationale of the CHILL phase II trial of hypothermia and neuromuscular blockade for acute respiratory distress syndrome Open
The Cooling to Help Injured Lungs (CHILL) trial is an open label, two group, parallel design multicenter, randomized phase IIB clinical trial assessing the efficacy and safety of targeted temperature management with combined external cooli…
View article: The Utility of ECMO in Acute Respiratory Distress Syndrome
The Utility of ECMO in Acute Respiratory Distress Syndrome Open
The state of knowledge regarding the adverse effects of mechanical ventilation in severe acute respiratory distress syndrome (ARDS) will be reviewed along with the benefits and limitations of lung protective ventilation strategies such as …
View article: Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease
Cortactin loss protects against hemin-induced acute lung injury in sickle cell disease Open
In patients with sickle cell disease (SCD), acute chest syndrome (ACS) is a common form of acute lung injury and a major cause of morbidity and mortality. The pathophysiology of ACS is complex, and hemin, the prosthetic moiety of hemoglobi…
View article: Cortactin Modulates Lung Endothelial Apoptosis Induced by Cigarette Smoke
Cortactin Modulates Lung Endothelial Apoptosis Induced by Cigarette Smoke Open
Cigarette smoke (CS) is the primary cause of Chronic Obstructive Pulmonary Disease (COPD), and an important pathophysiologic event in COPD is CS-induced apoptosis in lung endothelial cells (EC). Cortactin (CTTN) is a cytoskeletal actin-bin…
View article: Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2
Chronic E-Cigarette Aerosol Inhalation Alters the Immune State of the Lungs and Increases ACE2 Expression, Raising Concern for Altered Response and Susceptibility to SARS-CoV-2 Open
Conventional smoking is known to both increase susceptibility to infection and drive inflammation within the lungs. Recently, smokers have been found to be at higher risk of developing severe forms of coronavirus disease 2019 (COVID-19). E…
View article: Cortactin Dysfunction Mediates Cigarette Smoke-Induced Lung Endothelial Apoptosis
Cortactin Dysfunction Mediates Cigarette Smoke-Induced Lung Endothelial Apoptosis Open
Rationale: A key feature of cigarette smoke (CS)-induced lung disease, such as Chronic Obstructive Pulmonary Disease (COPD), is the dysfunction of the vascular endothelium; however, the underlying mechanisms remain incompletely defined.Lun…
View article: Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome
Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome Open
A history of chronic cigarette smoking is known to increase risk for acute respiratory distress syndrome (ARDS), but the corresponding risks associated with chronic e-cigarette use are largely unknown. The chromosomal fragile site gene, WW…
View article: Cigarette Smoke and Nicotine-Containing E-cigarette Vapor Downregulate Lung WWOX Expression Which is Associated with Increased Severity of Murine ARDS
Cigarette Smoke and Nicotine-Containing E-cigarette Vapor Downregulate Lung WWOX Expression Which is Associated with Increased Severity of Murine ARDS Open
RATIONALE A history of chronic cigarette smoking is known to increase risk for ARDS, but the corresponding risks associated with chronic e-cigarette use are largely unknown. The chromosomal fragile site gene, WWOX, is highly susceptible to…
View article: Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1
Micro-RNA-1 is decreased by hypoxia and contributes to the development of pulmonary vascular remodeling via regulation of sphingosine kinase 1 Open
Sphingosine kinase 1 (SphK1) upregulation is associated with pathologic pulmonary vascular remodeling in pulmonary arterial hypertension (PAH), but the mechanisms controlling its expression are undefined. In this study, we sought to charac…
View article: Hemin Causes Lung Microvascular Endothelial Barrier Dysfunction by Necroptotic Cell Death
Hemin Causes Lung Microvascular Endothelial Barrier Dysfunction by Necroptotic Cell Death Open
Hemin, the oxidized prosthetic moiety of hemoglobin, has been implicated in the pathogenesis of acute chest syndrome in patients with sickle cell disease by virtue of its endothelial-activating properties. In this study, we examined whethe…
View article: Loss of lung WWOX expression causes neutrophilic inflammation
Loss of lung WWOX expression causes neutrophilic inflammation Open
The tumor suppressor WW domain-containing oxidoreductase (WWOX) exhibits regulatory interactions with an array of transcription factors and signaling molecules that are positioned at the well-known crossroads between inflammation and cance…
View article: Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension
Nicotinamide Phosphoribosyltransferase Promotes Pulmonary Vascular Remodeling and Is a Therapeutic Target in Pulmonary Arterial Hypertension Open
Background: Pulmonary arterial hypertension is a severe and progressive disease, a hallmark of which is pulmonary vascular remodeling. Nicotinamide phosphoribosyltransferase (NAMPT) is a cytozyme that regulates intracellular nicotinamide a…
View article: Expression Profiling Elucidates a Molecular Gene Signature for Pulmonary Hypertension in Sarcoidosis
Expression Profiling Elucidates a Molecular Gene Signature for Pulmonary Hypertension in Sarcoidosis Open
Pulmonary hypertension (PH), when it complicates sarcoidosis, carries a poor prognosis, in part because it is difficult to detect early in patients with worsening respiratory symptoms. Pathogenesis of sarcoidosis occurs via incompletely ch…