Sunita A. Ramesh
YOU?
Author Swipe
View article: Semisynthetic indole alkaloids restrain the invasiveness of glioblastoma cell lines and inhibit human Aquaporin-1 water channels
Semisynthetic indole alkaloids restrain the invasiveness of glioblastoma cell lines and inhibit human Aquaporin-1 water channels Open
View article: Mapping and Cataloguing Microbial and Biochemical Determinants of Health: Towards a ‘Database of Salutogenic Potential’
Mapping and Cataloguing Microbial and Biochemical Determinants of Health: Towards a ‘Database of Salutogenic Potential’ Open
Microbial and biochemical research has historically focused on pathogenic agents due to their clear association with disease. This is a perspective that has saved countless lives but encourages a skewed, threat‐centered view of microbes an…
View article: Contrasting Microbial Taxonomic and Functional Colonisation Patterns in Wild Populations of the Pan‐Palaeotropical C4 Grass, <i>Themeda triandra</i>
Contrasting Microbial Taxonomic and Functional Colonisation Patterns in Wild Populations of the Pan‐Palaeotropical C4 Grass, <i>Themeda triandra</i> Open
The interactions between native plants and soil microbiota are not well characterised, despite growing recognition of their importance for host plant fitness and ecological functioning. We used shotgun metagenomics to examine microbial tax…
View article: Arid Soil Bacterial Legacies Improve Drought Resilience of the Keystone Grass, <scp><i>Themeda triandra</i></scp>
Arid Soil Bacterial Legacies Improve Drought Resilience of the Keystone Grass, <span><i>Themeda triandra</i></span> Open
Plant–microbe interactions are critical to ecosystem functioning and impact soil legacies, where plants exert a lasting influence on the microbial and physicochemical conditions of the soils in which they grow. These soil legacies can affe…
View article: Opportunities, challenges, and policy implications of the aerobiome paradigm shift
Opportunities, challenges, and policy implications of the aerobiome paradigm shift Open
Historically, bioaerosol research has focused on identifying and mitigating the harmful effects of airborne pathogens and particles. These bioaerosols—including bacteria, viruses, fungal spores, and non-biological particles, such as partic…
View article: Strong Host Modulation of Rhizosphere‐to‐Endosphere Microbial Colonisation in Natural Populations of the Pan‐Palaeotropical Keystone Grass Species, <i>Themeda triandra</i>
Strong Host Modulation of Rhizosphere‐to‐Endosphere Microbial Colonisation in Natural Populations of the Pan‐Palaeotropical Keystone Grass Species, <i>Themeda triandra</i> Open
Soil microbiota can colonise plant roots through a two‐step selection process, involving recruitment of microbiota first from bulk soil into plant rhizospheres, then into root endospheres. This process is poorly understood in all but a few…
View article: The climate change–pollution–aerobiome nexus: A ‘systems thinking’ mini‐review
The climate change–pollution–aerobiome nexus: A ‘systems thinking’ mini‐review Open
The interrelationship between climate change, pollution and the aerobiome (the microbiome of the air) is a complex ecological dynamic with profound implications for human and ecosystem health. This mini‐review explores the multifaceted rel…
View article: Ecological phage therapy: Can bacteriophages help rapidly restore the soil microbiome?
Ecological phage therapy: Can bacteriophages help rapidly restore the soil microbiome? Open
Soil microbiota underpin ecosystem functionality yet are rarely targeted during ecosystem restoration. Soil microbiota recovery following native plant revegetation can take years to decades, while the effectiveness of soil inoculation trea…
View article: Characterization of human aquaporin ion channels in a yeast expression system as a tool for novel ion channel discovery
Characterization of human aquaporin ion channels in a yeast expression system as a tool for novel ion channel discovery Open
Aquaporin (AQP) channels found in all domains of life are transmembrane proteins which mediate passive transport of water, glycerol, signaling molecules, metabolites, and charged solutes. Discovery of new classes of ion-conducting AQP chan…
View article: Increasing aridity strengthens the core bacterial rhizosphere associations in the pan-palaeotropical C4 grass, Themeda triandra
Increasing aridity strengthens the core bacterial rhizosphere associations in the pan-palaeotropical C4 grass, Themeda triandra Open
Understanding belowground plant-microbial interactions is fundamental to predicting how plant species respond to climate change, particularly in global drylands. However, these interactions are poorly understood, especially for keystone gr…
View article: Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes
Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes Open
Despite mounting evidence of their importance in human health and ecosystem functioning, the definition and measurement of 'healthy microbiomes' remain unclear. More advanced knowledge exists on health associations for compounds used or pr…
View article: Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes
Bioenergetic mapping of ‘healthy microbiomes’ via compound processing potential imprinted in gut and soil metagenomes Open
Despite mounting evidence of their importance in human health and ecosystem functioning, the definition and measurement of ‘healthy microbiomes’ remain unclear. More advanced knowledge exists on health associations for compounds used or pr…
View article: Increasing aridity strengthens core bacterial rhizosphere associations in the pan-palaeotropical C4 grass, Themeda triandra
Increasing aridity strengthens core bacterial rhizosphere associations in the pan-palaeotropical C4 grass, Themeda triandra Open
Interactions between soil microbiota and keystone plant species in grassland ecosystems are poorly understood, yet these interactions are fundamental to grassland ecosystem dynamics (e.g., responses to climate change). Here, we used 16S rR…
View article: Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro
Pharmacological Inhibition of Membrane Signaling Mechanisms Reduces the Invasiveness of U87-MG and U251-MG Glioblastoma Cells In Vitro Open
Impairing the motility of glioblastoma multiforme (GBM) cells is a compelling goal for new approaches to manage this highly invasive and rapidly lethal human brain cancer. Work here characterized an array of pharmacological inhibitors of m…
View article: The function of the <i>Medicago truncatula</i> ZIP transporter MtZIP14 is linked to arbuscular mycorrhizal fungal colonization
The function of the <i>Medicago truncatula</i> ZIP transporter MtZIP14 is linked to arbuscular mycorrhizal fungal colonization Open
Soil micronutrient availability, including zinc (Zn), is a limiting factor for crop yield. Arbuscular mycorrhizal (AM) fungi can improve host plant growth and nutrition through the mycorrhizal pathway of nutrient uptake. Although the physi…
View article: Proteoliposomes reconstituted with human aquaporin-1 reveal novel single-ion-channel properties
Proteoliposomes reconstituted with human aquaporin-1 reveal novel single-ion-channel properties Open
View article: Insights into Long-Term Acclimation Strategies of Grapevines (Vitis vinifera L.) in Response to Multi-Decadal Cyclical Drought
Insights into Long-Term Acclimation Strategies of Grapevines (Vitis vinifera L.) in Response to Multi-Decadal Cyclical Drought Open
Changing climatic conditions across Australia’s viticulture regions is placing increasing pressure on resources such as water and energy for irrigation. Therefore, there is a pressing need to identify superior drought tolerant grapevine cl…
View article: Picrotoxin Delineates Different Transport Configurations for Malate and γ Aminobutyric Acid through TaALMT1
Picrotoxin Delineates Different Transport Configurations for Malate and γ Aminobutyric Acid through TaALMT1 Open
Plant-derived pharmacological agents have been used extensively to dissect the structure–function relationships of mammalian GABA receptors and ion channels. Picrotoxin is a non-competitive antagonist of mammalian GABAA receptors. Here, we…
View article: Insights into Long-term Acclimation Strategies of Grapevines in Response to Multi-decadal Cyclical Drought
Insights into Long-term Acclimation Strategies of Grapevines in Response to Multi-decadal Cyclical Drought Open
The Australian wine industry is currently under pressure to sustain its profitability due to climate change. Therefore, there is a pressing need to explore grapevine genetic diversity and identify superior clones with improved drought resi…
View article: Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology
Aquaporin ion conductance properties defined by membrane environment, protein structure, and cell physiology Open
View article: Malate Transport and Metabolism in Nitrogen-Fixing Legume Nodules
Malate Transport and Metabolism in Nitrogen-Fixing Legume Nodules Open
Legumes form a symbiosis with rhizobia, a soil bacterium that allows them to access atmospheric nitrogen and deliver it to the plant for growth. Biological nitrogen fixation occurs in specialized organs, termed nodules, that develop on the…
View article: Novel Ion Channel Targets and Drug Delivery Tools for Controlling Glioblastoma Cell Invasiveness
Novel Ion Channel Targets and Drug Delivery Tools for Controlling Glioblastoma Cell Invasiveness Open
Comprising more than half of all brain tumors, glioblastoma multiforme (GBM) is a leading cause of brain cancer-related deaths worldwide. A major clinical challenge is presented by the capacity of glioma cells to rapidly infiltrate healthy…
View article: Emerging Roles of γ Aminobutyric Acid (GABA) Gated Channels in Plant Stress Tolerance
Emerging Roles of γ Aminobutyric Acid (GABA) Gated Channels in Plant Stress Tolerance Open
The signaling role for γ-Aminobutyric acid (GABA) has been documented in animals for over seven decades. However, a signaling role for GABA in plants is just beginning to emerge with the discovery of putative GABA binding site/s and GABA r…
View article: Identification of a unique ZIP transporter involved in zinc uptake via the arbuscular mycorrhizal fungal pathway
Identification of a unique ZIP transporter involved in zinc uptake via the arbuscular mycorrhizal fungal pathway Open
Low soil zinc (Zn) availability is a limiting factor for crop yield, and increasing Zn content is a major target for the biofortification of major crops. Arbuscular mycorrhizal (AM) fungi associate with the roots of most terrestrial plant …
View article: Comparing Hydraulics Between Two Grapevine Cultivars Reveals Differences in Stomatal Regulation Under Water Stress and Exogenous ABA Applications
Comparing Hydraulics Between Two Grapevine Cultivars Reveals Differences in Stomatal Regulation Under Water Stress and Exogenous ABA Applications Open
Hydraulics of plants that have different strategies of stomatal regulation under water stress are relatively poorly understood. We explore how root and shoot hydraulics, stomatal conductance (g s), leaf and root aquaporin…
View article: Molecular Targets for Combined Therapeutic Strategies to Limit Glioblastoma Cell Migration and Invasion
Molecular Targets for Combined Therapeutic Strategies to Limit Glioblastoma Cell Migration and Invasion Open
The highly invasive nature of glioblastoma imposes poor prospects for patient survival. Molecular evidence indicates glioblastoma cells undergo an intriguing expansion of phenotypic properties to include neuron-like signaling using excitab…
View article: Common garden experiment reveals altered nutritional values and DNA methylation profiles in micropropagated three elite Ghanaian sweet potato genotypes
Common garden experiment reveals altered nutritional values and DNA methylation profiles in micropropagated three elite Ghanaian sweet potato genotypes Open
Micronutrient deficiency is the cause of multiple diseases in developing countries. Staple crop biofortification is an efficient means to combat such deficiencies in the diets of local consumers. Biofortified lines of sweet potato (Ipomoea…
View article: Evolution of chloroplast retrograde signaling facilitates green plant adaptation to land
Evolution of chloroplast retrograde signaling facilitates green plant adaptation to land Open
Chloroplast retrograde signaling networks are vital for chloroplast biogenesis, operation, and signaling, including excess light and drought stress signaling. To date, retrograde signaling has been considered in the context of land plant a…
View article: Common garden experiment reveals altered nutritional values and DNA methylation profiles in micropropagated three elite Ghanaian sweet potato genotypes
Common garden experiment reveals altered nutritional values and DNA methylation profiles in micropropagated three elite Ghanaian sweet potato genotypes Open
Micronutrient deficiency is the cause of multiple diseases in developing countries. Staple crop biofortification is an efficient means to combat such deficiencies in the diets of local consumers. Biofortified lines of sweet potato ( Ipomoe…
View article: Aluminum-Activated Malate Transporters Can Facilitate GABA Transport
Aluminum-Activated Malate Transporters Can Facilitate GABA Transport Open
Plant aluminum-activated malate transporters (ALMTs) are currently classified as anion channels; they are also known to be regulated by diverse signals, leading to a range of physiological responses. Gamma-aminobutyric acid (GABA) regulati…