Sunlong Li
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View article: Correlation of Cervical Sagittal Alignment, C1-C2 Fixation Angle and Age of Spontaneous Atlantoaxial Dislocation, its Clinical Significance
Correlation of Cervical Sagittal Alignment, C1-C2 Fixation Angle and Age of Spontaneous Atlantoaxial Dislocation, its Clinical Significance Open
The atlanto-occipital joint and atlantoaxial joint are considered to be the important functional parts of the human skull-cervical axis. Research has found that the rotation of the craniocervical spine mainly depends on the atlantoaxial jo…
View article: Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration
Histidine‐Engineered ZIF‐8 Nanoparticles for High‐Efficiency siRNA Delivery and Gene Therapy of Intervertebral Disc Degeneration Open
Ferroptosis is a major contributor to intervertebral disc degeneration (IVDD) and represents a promising therapeutic target; however, effective medications that specifically target ferroptosis are still lacking. Consequently, strategies ai…
View article: PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis
PTPN22 as a therapeutic target in intervertebral disc degeneration: Modulating mitophagy and pyroptosis through the PI3K/AKT/mTOR axis Open
In summary, PTPN22 knockdown alleviates IDD progression by reducing pyroptosis and ECM degradation through enhanced mitophagy. This highlights PTPN22 as a critical contributor to IDD and a promising therapeutic target.
View article: Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6
Screen of FDA-approved drug library identifies vitamin K as anti-ferroptotic drug for osteoarthritis therapy through Gas6 Open
View article: A water strider-inspired intestinal stent actuator for controllable adhesion and unidirectional biofluid picking
A water strider-inspired intestinal stent actuator for controllable adhesion and unidirectional biofluid picking Open
Soft-bodied aquatic organisms exhibit extraordinary navigation and mobility in liquid environments which inspiring the development of biomimetic actuators with complex movements. Stimulus-responsive soft materials including hydrogels and s…
View article: Screen of Fda-Approved Drug Library Identifies Vitamin K as Ferroptosis Inhibitor for Osteoarthritis Therapy Through Gas6
Screen of Fda-Approved Drug Library Identifies Vitamin K as Ferroptosis Inhibitor for Osteoarthritis Therapy Through Gas6 Open
View article: Janus Wettability-Enabled Cervical Pressure Sensors with Flexible Characteristics for Precision Monitoring
Janus Wettability-Enabled Cervical Pressure Sensors with Flexible Characteristics for Precision Monitoring Open
View article: Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF‐<i>κ</i>B Pathway
Corynoline Alleviates Osteoarthritis Development via the Nrf2/NF‐<i>κ</i>B Pathway Open
Purpose . OA is a multifactorial joint disease in which inflammation plays a substantial role in the destruction of joints. Corynoline (COR), a component of Corydalis bungeana Turcz. , has anti‐inflammatory effects. Materials and Methods .…
View article: The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration
The Potential Role of Cytokines in Diabetic Intervertebral Disc Degeneration Open
Intervertebral disc degeneration (IVDD) is a major cause of low back pain. Diabetes mellitus is a chronic inflammatory disease that may cause or aggravate IVDD; however, the mechanism by which diabetes induce IVDD is currently unclear. Com…
View article: Chrysophanol Prevents IL-1β-Induced Inflammation and ECM Degradation in Osteoarthritis Via the Sirt6/NF-κB and Nrf2/NF-κB Axis
Chrysophanol Prevents IL-1β-Induced Inflammation and ECM Degradation in Osteoarthritis Via the Sirt6/NF-κB and Nrf2/NF-κB Axis Open
View article: α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice
α-Cyperone (CYP) down-regulates NF-κB and MAPKs signaling, attenuating inflammation and extracellular matrix degradation in chondrocytes, to ameliorate osteoarthritis in mice Open
Inflammation and extracellular matrix (ECM) degradation have been implicated in the pathological process of osteoarthritis (OA). α-Cyperone is the main active component of the traditional Chinese medicine Cyperus rotundus L. In this…
View article: RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration
RNA-Binding Protein HuR Suppresses Inflammation and Promotes Extracellular Matrix Homeostasis via NKRF in Intervertebral Disc Degeneration Open
Intervertebral disc degeneration (IVDD) has been reported to be a major cause of low back pain. Studies have demonstrated that IVDD may be dysregulated at the transcriptional level; however, whether post-transcriptional regulation is invol…