Sanjay Kalra
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View article: Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study
Comprehensive analysis platform to understand, remedy, and eliminate amyotrophic lateral sclerosis (CAPTURE ALS): Study protocol for a Canadian multicenter, multimodal, longitudinal observational study Open
Background The marked heterogeneity of Amyotrophic Lateral Sclerosis (ALS) combined with a lack of biomarkers are key contributing factors to the lack of disease-modifying treatments. The Comprehensive Analysis Platform to Understand Remed…
View article: A meaningful prediction of functional decline in amyotrophic lateral sclerosis based on multi-event survival analysis
A meaningful prediction of functional decline in amyotrophic lateral sclerosis based on multi-event survival analysis Open
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of the motor neurons that causes progressive paralysis in patients. Current treatment options aim to prolong survival and improve quality of life. However, due to the heterogen…
View article: A meaningful prediction of functional decline in amyotrophic lateral sclerosis based on multi-event survival analysis
A meaningful prediction of functional decline in amyotrophic lateral sclerosis based on multi-event survival analysis Open
Amyotrophic lateral sclerosis (ALS) is a degenerative disorder of the motor neurons that causes progressive paralysis in patients. Current treatment options aim to prolong survival and improve quality of life. However, due to the heterogen…
View article: The 3+3 Meal Pattern
The 3+3 Meal Pattern Open
This communication reviews the 3 + 3 meal pattern, a pillarof conventional nutritional therapy. It describes thestrengths, weaknesses, opportunities and challenges of thistype of therapy, and lists indications for its promotion.These can b…
View article: Dialysis in crisis: Delivering renal replacement therapy in disasters, conflicts, and resource-constrained settings
Dialysis in crisis: Delivering renal replacement therapy in disasters, conflicts, and resource-constrained settings Open
Access to dialysis during crises such as natural disasters,armed conflicts, pandemics, or in low-resource settingsremains a significant global challenge. Vulnerablepopulations requiring chronic or acute dialysis aredisproportionately affec…
View article: Progressive and short-interval changes observed in the corticospinal tract and corpus callosum of ALS patients: A texture analysis study
Progressive and short-interval changes observed in the corticospinal tract and corpus callosum of ALS patients: A texture analysis study Open
ALS＝ Amyotrophic lateral sclerosis; CST＝ corticospinal tract; CC = corpus callosum; ALSFRS-R= ALS functional rating scale-revised; CALSNIC = Canadian ALS Neuroimaging Consortium; DPR = disease progression rate; ECAS = Edinburgh Cognitive a…
View article: The Testosterone: Cortisol Ratio - A Tool with Practical Use and Research Potential in Endocrinology
The Testosterone: Cortisol Ratio - A Tool with Practical Use and Research Potential in Endocrinology Open
Testosterone is a predominantly anabolic hormone whereas cortisol is a catabolic hormone. Measurement of testosterone-cortisol ratio (TCR) can serve as a surrogate for the balance in the anabolic: catabolic states in the body and was studi…
View article: Expecting the unexpected: Identification and nonsurgical endodontic management of foreign body inside the root canal space postdental trauma
Expecting the unexpected: Identification and nonsurgical endodontic management of foreign body inside the root canal space postdental trauma Open
Dental trauma in the young age group may lead to exposed pulp and root canal space, particularly in anterior teeth. Children often present with habits of pricking their teeth using pins, needles, nails or metal screws as a part of their gr…
View article: Metabolic Nephrology
Metabolic Nephrology Open
Nephrology faces a paradox. The prevalence of kidneydisease is rising, in spite of advances in diagnostic,preventive and therapeutic strategies. This has kindledinterest in the discipline. Once considered a subspecialtyof general medicine,…
View article: Glucodynia
Glucodynia Open
Pain in patients with diabetes can be unpleasant, but attimes protective as well. We propose the term ‘glucodynia’i.e., an unpleasant sensory and emotional experience,associated with or without any organ-system dysfunction,in people living…
View article: Prevalence of diabetes distress among people with type 2 diabetes in South Asia: A systematic review and meta-analysis.
Prevalence of diabetes distress among people with type 2 diabetes in South Asia: A systematic review and meta-analysis. Open
South Asians with T2D seem to experience a relatively high burden of DD, and the emotional burden is the most common form of DD in this area. Larger studies utilizing unique tools and involving a broader participant base from the region wo…
View article: Differentiating upper- and lower motor neuron diseases using automated acoustic analysis
Differentiating upper- and lower motor neuron diseases using automated acoustic analysis Open
Our study demonstrated that acoustic assessment could capture fingerprints of dysarthrias associated with PLS and SBMA. These findings also demonstrate the potential for remote speech assessment to characterize diverse dysarthria profiles …
View article: P.102 Clinical predictors of disease progression and survival in ALS: insights from the Canadian Neuromuscular Disease Registry
P.102 Clinical predictors of disease progression and survival in ALS: insights from the Canadian Neuromuscular Disease Registry Open
Background: Amyotrophic Lateral Sclerosis (ALS) leads to progressive functional decline and reduced survival. Identifying clinical predictors like ALSFRS-R and FVC is essential for prognosis and disease management. Understanding progressio…
View article: Pathological Aging of Patients With Amyotrophic Lateral Sclerosis: A Preliminary Longitudinal Study
Pathological Aging of Patients With Amyotrophic Lateral Sclerosis: A Preliminary Longitudinal Study Open
Objective This longitudinal study investigated pathological brain aging in amyotrophic lateral sclerosis (ALS) by evaluating disparities between chronological age and deep learning‐derived brain structure age (BSA) and exploring associatio…
View article: Obesonomics
Obesonomics Open
Economic and commercial determinants of health, as wellas health- related determinants of economy, are graduallybeing understood by researchers and public healthspecialists. One condition which is influenced by economicfactors, and which a…
View article: Choice of Insulin Coformulations: Biphasic Insulin Versus Insulin-GlP1RA
Choice of Insulin Coformulations: Biphasic Insulin Versus Insulin-GlP1RA Open
This communication presents a pragmatic approachto describe the phenotypes which match with preferential usage of dual phase insulin or basal insulin+ glucagon-like peptide 1 receptor agonist (GLP1RA)coformulations. A comprehensive evaluat…
View article: Vitamin D deficiency: a cause of clinical concern
Vitamin D deficiency: a cause of clinical concern Open
In India, the prevalence of vitamin D deficiency ranges from 35% to 99% despite the fact that India is a tropical country with plenty of sunshine. The prevalence of vitamin D deficiency is high in patients with comorbid conditions such as …
View article: Asthenia in primary care; The 3me mnemonic
Asthenia in primary care; The 3me mnemonic Open
complaint. Asthenia is a subjective, static feeling of weakness, not necessarily related to effort. We propose a simple algorithm which can help primary care physicians in evaluation and counselling of persons presenting with asthenia. (Ta…
View article: Electrolyte Inertia In Chronic Kidney Disease
Electrolyte Inertia In Chronic Kidney Disease Open
Electrolyte imbalances are a common and challengingaspect of managing chronic kidney disease (CKD). Despiteadvances in treatment, a phenomenon known as"electrolyte inertia"- the inertness to correcting abnormalelectrolyte levels- may persi…
View article: Optimizing Kidney Disease Management during Ramadan: Evidence-Based Risk Stratification and Tailored Strategies
Optimizing Kidney Disease Management during Ramadan: Evidence-Based Risk Stratification and Tailored Strategies Open
Fasting during Ramadan poses distinct challenges forindividuals with kidney disease, requiring a careful balancebetween spiritual commitments and health maintenance.This article combines insights from recent research andguidelines to offer…
View article: Motivational Therapeutics and Medicine
Motivational Therapeutics and Medicine Open
Motivation is an essential part of medicine. The best of medication will have no benefit if the patient is not motivated to accept or adhere to prescribed therapy. Motivational therapeutics, therefore, becomes an integral part of every pat…
View article: Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation‐Based Morphometry Study
Regional Cerebral Atrophy Contributes to Personalized Survival Prediction in Amyotrophic Lateral Sclerosis: A Multicentre, Machine Learning, Deformation‐Based Morphometry Study Open
Objective Accurate personalized survival prediction in amyotrophic lateral sclerosis is essential for effective patient care planning. This study investigates whether grey and white matter changes measured by magnetic resonance imaging can…
View article: The Sociocebo, Socioebo, Or Socebo Effect
The Sociocebo, Socioebo, Or Socebo Effect Open
The impact of the surrounding social ecosystem on thewellbeing of an individual is well known. Based on thisconcept in this brief article we propose a novel termcalled the socebo effect, which may be defined as thepositive impact that occu…
View article: Navigating Hyperkalaemia- The A-to-H Clinical Strategy
Navigating Hyperkalaemia- The A-to-H Clinical Strategy Open
Hyperkalaemia is a life-threatening dyselectrolytaemiawhich is characterized by elevated serum potassiumlevels. It needs a systematic and overarching approach toeffectively manage a case of hyperkalaemia. We proposea structured A-to-H appr…