Surabhi Devaraj
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View article: I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression
I-BET151 modulates glucokinase gene expression and beta cell function in part through changes in FOXO1 expression Open
View article: A nutritional supplement taken during preconception and pregnancy influences human milk macronutrients in women with overweight/obesity and gestational diabetes mellitus
A nutritional supplement taken during preconception and pregnancy influences human milk macronutrients in women with overweight/obesity and gestational diabetes mellitus Open
Rational Maternal overweight/obesity and gestational diabetes mellitus (GDM) are associated with an increased risk of their offspring developing overweight/obesity or type 2 diabetes later in life. However, the impacts of maternal overweig…
View article: A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations
A nutritional supplement during preconception and pregnancy increases human milk vitamin D but not B-vitamin concentrations Open
Registered at ClinicalTrials.gov on the 16 July 2015 (identifier NCT02509988); Universal Trial Number U1111-1171-8056. This study was academic-led by the EpiGen Global Research Consortium.
View article: Predictors of compliance with higher dose omega-3 fatty acid supplementation during pregnancy and implications for the risk of prematurity: exploratory analysis of the ORIP randomised trial
Predictors of compliance with higher dose omega-3 fatty acid supplementation during pregnancy and implications for the risk of prematurity: exploratory analysis of the ORIP randomised trial Open
Background Intention-to-treat analyses of the Omega‐3 to Reduce the Incidence of Prematurity (ORIP) trial found that omega-3 (n-3) fatty acid supplementation reduces the risk of prematurity in the subgroup of women with a singleton pregnan…
View article: Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial
Identifying women who may benefit from higher dose omega-3 supplementation during pregnancy to reduce their risk of prematurity: exploratory analyses from the ORIP trial Open
Objectives The risk factors for prematurity are multifactorial and include low omega-3 status. Omega-3 supplementation in pregnancy has been found to reduce prematurity risk, particularly among women with low omega-3 levels. This study aim…
View article: A nutritional supplement containing zinc during preconception and pregnancy increases human milk zinc concentrations
A nutritional supplement containing zinc during preconception and pregnancy increases human milk zinc concentrations Open
Introduction During pregnancy and lactation minerals such as zinc are required to support maternal and infant health. Zinc is involved in various cellular processes, with requirements increasing in pregnancy and lactation. In the setting o…
View article: Targeted Synthesis of 3,3′-, 3,4′- and 3,6′-Phenylpropanoid Sucrose Esters
Targeted Synthesis of 3,3′-, 3,4′- and 3,6′-Phenylpropanoid Sucrose Esters Open
In this study, we report on an orthogonal strategy for the precise synthesis of 3,3′-, 3,4′-, and 3,6′-phenylpropanoid sucrose esters (PSEs). The strategy relies on carefully selected protecting groups and deprotecting agents, taking into …
View article: Feruloyl Sucrose Esters: Potent and Selective Inhibitors of α-glucosidase and α-amylase
Feruloyl Sucrose Esters: Potent and Selective Inhibitors of α-glucosidase and α-amylase Open
Introduction: Feruloyl Sucrose Esters (FSEs) are a class of Phenylpropanoid Sucrose Esters (PSEs) widely distributed in plants. They were investigated as potential selective Alpha Glucosidase Inhibitors (AGIs) to eliminate the side effects…
View article: Cinnamoyl Sucrose Esters as Alpha Glucosidase Inhibitors for the Treatment of Diabetes
Cinnamoyl Sucrose Esters as Alpha Glucosidase Inhibitors for the Treatment of Diabetes Open
Cinnamoyl sucrose esters (CSEs) were evaluated as AGIs and their enzyme inhibition activity and potency were compared with gold standard acarbose. The inhibition activity of the CSEs against α-glucosidase and α-amylase depended on their st…
View article: Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis
Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis Open
View article: Development of phenylpropanoid sucrose esters (PSEs) as lead drug candidates for alpha glucosidase inhibition
Development of phenylpropanoid sucrose esters (PSEs) as lead drug candidates for alpha glucosidase inhibition Open
This research work focuses on the development of Phenylpropanoid Sucrose Esters (PSEs) as lead antidiabetic Alpha Glucosidase Inhibitors (AGIs) with the ultimate aim of eliminating the side effects associated with the current commercial dr…