Suresh K. Alahari
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View article: Assessing the Tumor Suppressive Impact and Regulatory Mechanisms of SPDEF Expression in Breast Cancer
Assessing the Tumor Suppressive Impact and Regulatory Mechanisms of SPDEF Expression in Breast Cancer Open
Background/Objectives: Breast cancer is a heterogeneous disease, and the role of the transcription factor SPDEF remains controversial. We aimed to clarify the prognostic value of SPDEF, explore demographic and molecular correlates of its e…
View article: The Non-Coding RNA Journal Club: Highlights on Recent Papers—14
The Non-Coding RNA Journal Club: Highlights on Recent Papers—14 Open
The field of non-coding RNA research is advancing at a breathtaking pace, continually uncovering new layers of regulatory complexity and functional diversity [...]
View article: Oncogenic effects of ECM remodeling in obesity and breast cancer
Oncogenic effects of ECM remodeling in obesity and breast cancer Open
Extracellular matrix (ECM) components are key regulators in breast cancer progression, as ECM remodeling is essential for breast cancer cells to invade into surrounding tissue. This process is characterized by the alignment of fibrillar co…
View article: NUAK kinases: Signaling mechanisms and therapeutic applications
NUAK kinases: Signaling mechanisms and therapeutic applications Open
The novel (nua) kinases 1 and 2 are two of 12 AMP-activated protein-related kinases whose signaling pathways are involved in cancer progression, as well as neurologic, fibrotic, and inflammatory diseases. Currently, there are 80 Food and D…
View article: Abstract 1420 Repurposing hypertensive drugs for breast cancer therapies
Abstract 1420 Repurposing hypertensive drugs for breast cancer therapies Open
View article: Caveolin-1: an ambiguous entity in breast cancer
Caveolin-1: an ambiguous entity in breast cancer Open
Breast cancer (BC) is the most frequently diagnosed cancer in women and the second leading cause of death from cancer among women. Metastasis is the major cause of BC-associated mortality. Accumulating evidence implicates Caveolin-1 (Cav-1…
View article: The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage
The 2024 Nobel Prize in Physiology or Medicine: microRNA Takes Center Stage Open
The Non-coding Journal Editorial Board Members would like to congratulate Victor Ambros and Gary Ruvkun, who were jointly awarded the 2024 Nobel Prize in Physiology or Medicine for their groundbreaking discovery of microRNAs and the role o…
View article: Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy
Small molecule Mcl-1 inhibitor for triple negative breast cancer therapy Open
Apoptosis is an evolutionarily conserved cell death pathway that plays a crucial role in maintaining tissue homeostasis, orchestrating organismal development, and eliminating damaged cells. Dysregulation of apoptosis can contribute to the …
View article: MicroRNA-532-3p Modulates Colorectal Cancer Cell Proliferation and Invasion via Suppression of FOXM1
MicroRNA-532-3p Modulates Colorectal Cancer Cell Proliferation and Invasion via Suppression of FOXM1 Open
Colorectal cancer (CRC) is a heterogeneous disease and classified into various subtypes, among which transcriptional alterations result in CRC progression, metastasis, and drug resistance. Forkhead-box M1 (FOXM1) is a proliferation-associa…
View article: Editorial: Reviews and advances in the molecular mechanisms of breast cancer
Editorial: Reviews and advances in the molecular mechanisms of breast cancer Open
EDITORIAL article Front. Cell Dev. Biol., 07 March 2024Sec. Cancer Cell Biology Volume 12 - 2024 | https://doi.org/10.3389/fcell.2024.1380475
View article: The Non-Coding RNA Journal Club: Highlights on Recent Papers—13
The Non-Coding RNA Journal Club: Highlights on Recent Papers—13 Open
We are delighted to share with you our thirteenth Journal Club and highlight some of the most interesting papers published recently [...]
View article: Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy
Targeting Mcl-1 by a small molecule NSC260594 for triple-negative breast cancer therapy Open
Triple-negative breast cancers (TNBCs) are aggressive forms of breast cancer and tend to grow and spread more quickly than most other types of breast cancer. TNBCs can neither be targeted by hormonal therapies nor the antibody trastuzumab …
View article: 17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer
17β-estradiol promotes extracellular vesicle release and selective miRNA loading in ERα-positive breast cancer Open
The causes and consequences of abnormal biogenesis of extracellular vesicles (EVs) are not yet well understood in malignancies, including in breast cancers (BCs). Given the hormonal signaling dependence of estrogen receptor–positive (ER+) …
View article: The Non-Coding RNA Journal Club: Highlights on Recent Papers—12
The Non-Coding RNA Journal Club: Highlights on Recent Papers—12 Open
We are delighted to share with you our twelfth Journal Club and highlight some of the most interesting papers published recently [...]
View article: LKB1 signaling and patient survival outcomes in hepatocellular carcinoma
LKB1 signaling and patient survival outcomes in hepatocellular carcinoma Open
The liver is a major organ that is involved in essential biological functions such as digestion, nutrient storage, and detoxification. Furthermore, it is one of the most metabolically active organs with active roles in regulating carbohydr…
View article: Supplementary Figure 2 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 2 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Characterization of Exosomes in Human Cell Lines
View article: Supplementary Figure 4 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 4 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Caspase 3 Staining of Mouse Tumors From Exosome Studies
View article: Supplementary Figure 1 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 1 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Nischarin Decreases the Attachment of Breast Cancer Cells
View article: Supplementary Figure 5 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 5 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Schematic Representation of the Effects of Nischarin on Breast Cancer Cell Motility through Exosomes
View article: Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Exosomes are small extracellular microvesicles that are secreted by cells when intracellular multivesicular bodies fuse with the plasma membrane. We have previously demonstrated that Nischarin inhibits focal adhesion formation, cell migrat…
View article: Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Exosomes are small extracellular microvesicles that are secreted by cells when intracellular multivesicular bodies fuse with the plasma membrane. We have previously demonstrated that Nischarin inhibits focal adhesion formation, cell migrat…
View article: Supplementary Figure 3 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 3 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Exosomes from Nischarin Tumors Reduce Focal Adhesions and Cell Spreading
View article: Supplementary Figure 5 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 5 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Schematic Representation of the Effects of Nischarin on Breast Cancer Cell Motility through Exosomes
View article: Supplementary Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Supplementary Figure legends
View article: Supplementary Figure 3 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 3 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Exosomes from Nischarin Tumors Reduce Focal Adhesions and Cell Spreading
View article: Supplementary Figure 1 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 1 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Nischarin Decreases the Attachment of Breast Cancer Cells
View article: Supplementary Figure 4 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 4 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Caspase 3 Staining of Mouse Tumors From Exosome Studies
View article: Supplementary Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Data from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Supplementary Figure legends
View article: Supplementary Figure 2 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth
Supplementary Figure 2 from Exosomes from Nischarin-Expressing Cells Reduce Breast Cancer Cell Motility and Tumor Growth Open
Characterization of Exosomes in Human Cell Lines
View article: Supplementary Figure Legend from Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/<i>Neu</i>, EGF, and TNF-α in Breast Cancer
Supplementary Figure Legend from Prooncogenic Factors miR-23b and miR-27b Are Regulated by Her2/<i>Neu</i>, EGF, and TNF-α in Breast Cancer Open
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