Suresh K. Mittal
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View article: Trained ILCs confer adaptive immunity-independent protection against influenza
Trained ILCs confer adaptive immunity-independent protection against influenza Open
Seasonal influenza causes 290,000–650,000 deaths annually, with vaccination efficacy ranging from 10 to 60%. The emergence of drug-resistant and highly pathogenic avian influenza viruses underscores the urgent need for novel protective str…
View article: Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Animal DNA Viruses and Retroviruses Subcommittee, 2025
Summary of taxonomy changes ratified by the International Committee on Taxonomy of Viruses (ICTV) from the Animal DNA Viruses and Retroviruses Subcommittee, 2025 Open
The International Committee on Taxonomy of Viruses (ICTV) holds a ratification vote annually after review of newly proposed taxa by ICTV Study Groups and members of the virology community. In March 2025, the vote outcome of the 11 proposal…
View article: Clinical, biochemical, and radiological profile of adult patients with primary hyperparathyroidism operated at a single tertiary care center in North India
Clinical, biochemical, and radiological profile of adult patients with primary hyperparathyroidism operated at a single tertiary care center in North India Open
Objective: Limited studies have examined the profile of only those primary hyperparathyroidism (PHPT) patients who had parathyroid surgery in the Indian context. This study aimed to analyse the clinical, biochemical, and radiological profi…
View article: A bovine adenoviral-vector-based universal influenza vaccine confers protection against influenza A and B viruses in mice and ferrets
A bovine adenoviral-vector-based universal influenza vaccine confers protection against influenza A and B viruses in mice and ferrets Open
Current seasonal influenza vaccines offer strain-specific protection and, thus, are less effective against mismatched strains. A broadly protective influenza vaccine is desirable to provide comprehensive protection against a wide range of …
View article: Bovine Adenoviral Vector-Based Platform for Vaccine Development
Bovine Adenoviral Vector-Based Platform for Vaccine Development Open
Adenoviral (AdV) vector-based vaccines employing the human AdV (HAdV) and chimpanzee AdV (ChAdV) vector platforms played a crucial role in combating the COVID-19 pandemic. However, the widespread use of these platforms, the prevalence of v…
View article: Next-Generation Adenoviral Vector-Based Vaccines for Severe Acute Respiratory Syndrome Coronavirus-2
Next-Generation Adenoviral Vector-Based Vaccines for Severe Acute Respiratory Syndrome Coronavirus-2 Open
This review systematically revises adenovirus (Ad) biology, vector structure, immune responses, and currently available Ad vector COVID-19 vaccines. It analyzes the challenges associated with the Ad vector-based vaccines, including preexis…
View article: Occurrence and Predictors of Diabetes Distress in Adult Patients with Type 2 Diabetes from North India
Occurrence and Predictors of Diabetes Distress in Adult Patients with Type 2 Diabetes from North India Open
Introduction: There is limited data regarding the prevalence and predictors of diabetes distress in Indians with type 2 diabetes (T2D). The study aimed to determine the occurrence and predictors of diabetes distress in adult persons with T…
View article: Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses
Adenoviral Vector-Based Vaccine Expressing Hemagglutinin Stem Region with Autophagy-Inducing Peptide Confers Cross-Protection Against Group 1 and 2 Influenza A Viruses Open
Background/Objectives: An effective universal influenza vaccine is urgently needed to overcome the limitations of current seasonal influenza vaccines, which are ineffective against mismatched strains and unable to protect against pandemic …
View article: Clinical and Biochemical Profiles of Hospitalized Patients with Hypercalcaemia from a Tertiary Care Centre in North India
Clinical and Biochemical Profiles of Hospitalized Patients with Hypercalcaemia from a Tertiary Care Centre in North India Open
Background and aims: The profile of hypercalcaemia in hospitalized patients in India seems to be changing. However, studies evaluating the profile of hypercalcaemia in hospitalized settings in India are extremely limited. This prospective …
View article: The frequency and function of nucleoprotein-specific CD8 <sup>+</sup> T cells are critical for heterosubtypic immunity against influenza virus infection
The frequency and function of nucleoprotein-specific CD8 <sup>+</sup> T cells are critical for heterosubtypic immunity against influenza virus infection Open
Cytotoxic T lymphocytes (CTLs) mediate host defense against viral and intracellular bacterial infections and tumors. However, the magnitude of CTL response and their function needed to confer heterosubtypic immunity against influenza virus…
View article: Development of NP-Based Universal Vaccine for Influenza A Viruses
Development of NP-Based Universal Vaccine for Influenza A Viruses Open
The nucleoprotein (NP) is a vital target for the heterosubtypic immunity of CD8+ cytotoxic T lymphocytes (CTLs) due to its conservation among influenza virus subtypes. To further enhance the T cell immunity of NP, autophagy-inducing peptid…
View article: Enhancement of mucosal innate and adaptive immunity following intranasal immunization of mice with a bovine adenoviral vector
Enhancement of mucosal innate and adaptive immunity following intranasal immunization of mice with a bovine adenoviral vector Open
Introduction Nonhuman adenoviral (AdV) gene delivery platforms have significant value due to their ability to elude preexisting AdV vector immunity in most individuals. Previously, we have demonstrated that intranasal (IN) immunization of …
View article: Impact of an autophagy-inducing peptide on immunogenicity and protection efficacy of an adenovirus-vectored SARS-CoV-2 vaccine
Impact of an autophagy-inducing peptide on immunogenicity and protection efficacy of an adenovirus-vectored SARS-CoV-2 vaccine Open
Because of continual generation of new variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), it is critical to design the next generation of vaccines to combat the threat posed by SARS-CoV-2 variants. We developed human…
View article: Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy
Significance of Preexisting Vector Immunity and Activation of Innate Responses for Adenoviral Vector-Based Therapy Open
An adenoviral (AdV)-based vector system is a promising platform for vaccine development and gene therapy applications. Administration of an AdV vector elicits robust innate immunity, leading to the development of humoral and cellular immun…
View article: Progress towards the Development of a Universal Influenza Vaccine
Progress towards the Development of a Universal Influenza Vaccine Open
Influenza viruses are responsible for millions of cases globally and significantly threaten public health. Since pandemic and zoonotic influenza viruses have emerged in the last 20 years and some of the viruses have resulted in high mortal…
View article: ICTV Virus Taxonomy Profile: Adenoviridae 2022
ICTV Virus Taxonomy Profile: Adenoviridae 2022 Open
The family Adenoviridae includes non-enveloped viruses with linear dsDNA genomes of 25–48 kb and medium-sized icosahedral capsids. Adenoviruses have been discovered in vertebrates from fish to humans. The family is divided into six genera,…
View article: Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases
Nonhuman Adenoviral Vector-Based Platforms and Their Utility in Designing Next Generation of Vaccines for Infectious Diseases Open
Several human adenoviral (Ad) vectors have been developed for vaccine delivery owing to their numerous advantages, including the feasibility of different vector designs, the robustness of elicited immune responses, safety, and scalability.…
View article: Loss of <i>smarcad1a</i> accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish
Loss of <i>smarcad1a</i> accelerates tumorigenesis of malignant peripheral nerve sheath tumors in zebrafish Open
Malignant peripheral nerve sheath tumors (MPNSTs) are a type of sarcoma that generally originates from Schwann cells. The prognosis for this type of malignancy is relatively poor due to complicated genetic alterations and the lack of speci…
View article: Influenza Virus Infects and Depletes Activated Adaptive Immune Responders
Influenza Virus Infects and Depletes Activated Adaptive Immune Responders Open
Influenza infections cause several million cases of severe respiratory illness, hospitalizations, and hundreds of thousands of deaths globally. Secondary infections are a leading cause of influenza's high morbidity and mortality, and signi…
View article: Adenoviral vector‐based platforms for developing effective vaccines to combat respiratory viral infections
Adenoviral vector‐based platforms for developing effective vaccines to combat respiratory viral infections Open
Since the development of the first vaccine against smallpox over two centuries ago, vaccination strategies have been at the forefront of significantly impacting the incidences of infectious diseases globally. However, the increase in the h…
View article: A potential approach for assessing the quality of human and nonhuman adenoviral vector preparations.
A potential approach for assessing the quality of human and nonhuman adenoviral vector preparations. Open
Various types of human and nonhuman adenoviral (AdV) vectors are being used as gene delivery vectors in preclinical and clinical investigations. The objective of this study was to determine the ratio between the 2 best assays that would ef…
View article: Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines
Adenoviral Vector-Based Vaccine Platforms for Developing the Next Generation of Influenza Vaccines Open
Ever since the discovery of vaccines, many deadly diseases have been contained worldwide, ultimately culminating in the eradication of smallpox and polio, which represented significant medical achievements in human health. However, this do…
View article: Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish
Potassium Channel-Associated Bioelectricity of the Dermomyotome Determines Fin Patterning in Zebrafish Open
It has long been recognized that the morphological complexity of vertebrates is established by spatially- and temporally-regulated cell signaling. For decades, studies of the molecular mechanisms....
View article: Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer
Ductal Carcinoma In Situ Progression in Dog Model of Breast Cancer Open
The mechanisms that drive ductal carcinoma in situ (DCIS) progression to invasive cancer are not clear. Studying DCIS progression in humans is challenging and not ethical, thus necessitating the characterization of an animal model that fai…
View article: Sexual Dimorphism in Patients with COVID-19: Review
Sexual Dimorphism in Patients with COVID-19: Review Open
University of Miami Miller School of Medicine says men across the globe are at 3 times risk of dying in a hospital from COVID-19 as females. 5Chinese Centre for disease control and prevention found the male to female ratio of COVID-19 case…
View article: Thyroid symptomatology across the spectrum of hypothyroidism and impact of levothyroxine supplementation in patients with severe primary hypothyroidism
Thyroid symptomatology across the spectrum of hypothyroidism and impact of levothyroxine supplementation in patients with severe primary hypothyroidism Open
Thyroid symptomatology differs significantly across spectrum of hypothyroidism, being significantly worse in SPH. Euthyroidism restoration is associated with reversal of majority of thyroid symptomatology.