Surinder Jeet
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View article: Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis
Targeting CDK7/12/13 functional synergism reverses myofibroblast activation and ameliorates lung fibrosis Open
View article: Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade
Induction of a distinct macrophage population and protection from lung injury and fibrosis by Notch2 blockade Open
View article: Lung-innervating neurons expressing<i>Tmc3</i>can induce broncho-constriction and dilation with direct consequences for the respiratory cycle
Lung-innervating neurons expressing<i>Tmc3</i>can induce broncho-constriction and dilation with direct consequences for the respiratory cycle Open
Sensory neurons of the vagal ganglia (VG) innervate lungs and play a critical role in maintaining airway homeostasis. However, the specific VG neurons that innervate lungs, and the mechanisms by which these neurons sense and respond to air…
View article: An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases
An agonistic anti-signal regulatory protein α antibody for chronic inflammatory diseases Open
Signal regulatory protein (SIRPα) is an immune inhibitory receptor expressed by myeloid cells to inhibit immune cell phagocytosis, migration, and activation. Despite the progress of SIRPα and CD47 antagonist antibodies to promote anti-canc…
View article: LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung
LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung Open
Idiopathic pulmonary fibrosis is a progressive fibrotic disease characterized by excessive deposition of (myo)fibroblast produced collagen fibrils in alveolar areas of the lung. Lysyl oxidases (LOXs) have been proposed to be the central en…
View article: Obligate role for Rock1 and Rock2 in adult stem cell viability and function
Obligate role for Rock1 and Rock2 in adult stem cell viability and function Open
The ability of stem cells to rapidly proliferate and differentiate is integral to the steady-state maintenance of tissues with high turnover such as the blood and intestine. Mutations that alter these processes can cause primary immunodefi…
View article: BMP1 is not required for lung fibrosis in mice
BMP1 is not required for lung fibrosis in mice Open
Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like family of zinc metalloproteinases, which play a fundamental role in the development and formation of extracellular matrix (ECM). BMP1 mediates the cleavage of car…
View article: BMP1 is Not Required for Lung Fibrosis in Mice
BMP1 is Not Required for Lung Fibrosis in Mice Open
Bone morphogenetic protein 1 (BMP1) belongs to the astacin/BMP1/tolloid-like family of zinc metalloproteinases, which play a fundamental role in the development and formation of extracellular matrix (ECM). BMP1 mediates the cleavage of car…
View article: A WISP1 Antibody Inhibits MRTF Signaling to Prevent the Progression of Established Liver Fibrosis
A WISP1 Antibody Inhibits MRTF Signaling to Prevent the Progression of Established Liver Fibrosis Open
View article: Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer
Function of CSF1 and IL34 in Macrophage Homeostasis, Inflammation, and Cancer Open
Colony-stimulating factor 1 (CSF1) and interleukin 34 (IL34) signal via the CSF1 receptor to regulate macrophage differentiation. Studies in IL34- or CSF1-deficient mice have revealed that IL34 function is limited to the central ner…
View article: IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis
IL-17A is associated with the breakdown of the blood-brain barrier in relapsing-remitting multiple sclerosis Open
IL-17 has been implicated in the pathogenesis of multiple sclerosis (MS). Here, we show that blockade of IL-17A, but not IL-17F, attenuated experimental autoimmune encephalomyelitis (EAE). We further show that IL-17A levels were elevated i…
View article: Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling
Disruption of XIAP-RIP2 Association Blocks NOD2-Mediated Inflammatory Signaling Open
View article: Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions
Potassium channels Kv1.3 and KCa3.1 cooperatively and compensatorily regulate antigen-specific memory T cell functions Open
View article: RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury
RIPK3 deficiency or catalytically inactive RIPK1 provides greater benefit than MLKL deficiency in mouse models of inflammation and tissue injury Open
View article: Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation
Erratum: Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation Open
View article: Dendritic cells require NIK for CD40-dependent cross-priming of CD8 <sup>+</sup> T cells
Dendritic cells require NIK for CD40-dependent cross-priming of CD8 <sup>+</sup> T cells Open
Significance The noncanonical NF-κB signaling pathway via the serine kinase NIK (NF-κB–inducing kinase) is essential for normal immune system development and has been implicated in tumor cell survival and growth. Because NIK is under inves…
View article: Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies
Lack of Widespread BBB Disruption in Alzheimer’s Disease Models: Focus on Therapeutic Antibodies Open