Surya Pandey
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View article: 1138 Enhancement of CD8 T cell function with microbial tryptophan catabolites to boost cellular therapy efficacy in solid tumors
1138 Enhancement of CD8 T cell function with microbial tryptophan catabolites to boost cellular therapy efficacy in solid tumors Open
View article: 1132 Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity against ICI-resistant melanoma
1132 Exercise-induced microbiota metabolite enhances CD8 T cell antitumor immunity against ICI-resistant melanoma Open
View article: Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis
Cord blood proteomics identifies biomarkers of early-onset neonatal sepsis Open
BACKGROUNDSymptoms of early-onset neonatal sepsis (EOS) in preterm infants are nonspecific and overlap with normal postnatal physiological adaptations and noninfectious pathologies. This clinical uncertainty and the lack of reliable EOS di…
View article: 1253 Exercise-induced microbial folate metabolite enhances CD8 T cell antitumor immunity and promotes immunotherapy efficacy
1253 Exercise-induced microbial folate metabolite enhances CD8 T cell antitumor immunity and promotes immunotherapy efficacy Open
View article: MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy
MAPK/ERK signaling in gliomas modulates interferon responses, T cell recruitment, microglia phenotype, and immune checkpoint blockade efficacy Open
Background Glioblastoma (GB) remains a formidable challenge in neuro-oncology, with immune checkpoint blockade (ICB) showing limited efficacy in unselected patients. We previously recently established that MAPK/ERK signaling is associated …
View article: Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas
Ultrasound-mediated delivery of doxorubicin to the brain results in immune modulation and improved responses to PD-1 blockade in gliomas Open
Given the marginal penetration of most drugs across the blood-brain barrier, the efficacy of various agents remains limited for glioblastoma (GBM). Here we employ low-intensity pulsed ultrasound (LIPU) and intravenously administered microb…
View article: Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond
Immune Assessment Today: Optimizing and Standardizing Efforts to Monitor Immune Responses in Cancer and Beyond Open
As part of a symposium, current and former directors of Immune Monitoring cores and investigative oncologists presented insights into the past, present and future of immune assessment. Dr. Gnjatic presented a classification of immune monit…
View article: A pairwise cytokine code explains the organism-wide response to sepsis
A pairwise cytokine code explains the organism-wide response to sepsis Open
Sepsis is a systemic response to infection with life-threatening consequences. Our understanding of the molecular and cellular impact of sepsis across organs remains rudimentary. Here, we characterize the pathogenesis of sepsis by measurin…
View article: Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation
Organism-Wide Analysis of Sepsis Reveals Mechanisms of Systemic Inflammation Open
SUMMARY Sepsis is a systemic response to infection with life-threatening consequences. Our understanding of the impact of sepsis across organs of the body is rudimentary. Here, using mouse models of sepsis, we generate a dynamic, organism-…
View article: 1310 Dietary tryptophan catabolite released by intratumoral <i>Lactobacillus reuteri</i> facilitates anti-PD-L1 therapy
1310 Dietary tryptophan catabolite released by intratumoral <i>Lactobacillus reuteri</i> facilitates anti-PD-L1 therapy Open
Background The use of probiotic supplementation by cancer patients is increasing, including amongst those undergoing immune checkpoint inhibitor (ICI) therapy. While probiotic supplementation has been identified as an important factor infl…
View article: DDEL-13. ULTRASOUND-ENHANCED DELIVERY OF LIPOSOMAL DOXORUBICIN ACROSS THE BLOOD BRAIN BARRIER INDUCES AN IFN-GPHENOTYPE IN MICROGLIA, MACROPHAGES, AND T CELLS AND IMPROVES RESPONSE TO PD-1 BLOCKADE IN GLIOMAS
DDEL-13. ULTRASOUND-ENHANCED DELIVERY OF LIPOSOMAL DOXORUBICIN ACROSS THE BLOOD BRAIN BARRIER INDUCES AN IFN-GPHENOTYPE IN MICROGLIA, MACROPHAGES, AND T CELLS AND IMPROVES RESPONSE TO PD-1 BLOCKADE IN GLIOMAS Open
INTRODUCTION Given the limited drug penetration across the blood-brain barrier (BBB), the therapeutic potential of new and existing therapies has not been fully exploited for the benefit of glioblastoma (GBM) patients. METHODS Here we empl…
View article: Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates αPD-L1 therapy
Dietary tryptophan catabolite released by intratumoral Lactobacillus reuteri facilitates αPD-L1 therapy Open
The gut microbiome has been identified as a critical factor influencing cancer patient responses to immune checkpoint inhibitor (ICI) therapy; however, the underlying mechanisms of how gut microbes modulate ICI therapy efficacy remain enig…
View article: Study of Slowly Changing Dimension to Dependent Data Mart to Manage Finance Data
Study of Slowly Changing Dimension to Dependent Data Mart to Manage Finance Data Open
Financial institutions face many challenges of managing and marketing campaigns which leads in its data warehouse. The management of marketing campaign leads in dependent data mart with real time updating and recording difficulties especia…
View article: Systemic Immunoregulatory Consequences of Gut Commensal Translocation
Systemic Immunoregulatory Consequences of Gut Commensal Translocation Open
View article: Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations
Pairwise Stimulations of Pathogen-Sensing Pathways Predict Immune Responses to Multi-adjuvant Combinations Open
View article: Pairwise Interactions in Adjuvant Combinations Dictate Immune Responses and Inform Cancer Immunotherapy Design
Pairwise Interactions in Adjuvant Combinations Dictate Immune Responses and Inform Cancer Immunotherapy Design Open
SUMMARY The immune system makes decisions in response to complex combinations of microbial inputs. We do not understand the combinatorial logic that governs how the interplay between higher-order combinations of microbial or adjuvant signa…
View article: T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation
T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation Open
View article: A whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq
A whole-tissue RNA-seq toolkit for organism-wide studies of gene expression with PME-seq Open
View article: Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens
Correction to: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens Open
View article: Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens
Reducing IRF5 expression attenuates colitis in mice, but impairs the clearance of intestinal pathogens Open
View article: Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues
Organism-Level Analysis of Vaccination Reveals Networks of Protection across Tissues Open