Susan Chalmers
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View article: Mitochondria regulate inositol triphosphate‐mediated Ca<sup>2+</sup> release triggered by voltage‐dependent Ca<sup>2+</sup> entry in resistance arteries
Mitochondria regulate inositol triphosphate‐mediated Ca<sup>2+</sup> release triggered by voltage‐dependent Ca<sup>2+</sup> entry in resistance arteries Open
An increase in cytoplasmic Ca 2+ concentration activates multiple cellular activities, including cell division, metabolism, growth, contraction and death. In smooth muscle Ca 2+ entry via voltage‐dependent Ca 2+ channels leads to a relativ…
View article: Recounting the untold stories of breast cancer patient experiences: lessons learned from a patient–public involvement and engagement storytelling event
Recounting the untold stories of breast cancer patient experiences: lessons learned from a patient–public involvement and engagement storytelling event Open
Objectives Breast cancer remains a prevalent disease in women worldwide. Though advancements in breast cancer care have improved patient survival, a breast cancer diagnosis, and subsequent interventions have a lasting impact on patients’ l…
View article: A roadmap for patient-public involvement and engagement (PPIE): Recounting the untold stories of breast cancer patient experiences
A roadmap for patient-public involvement and engagement (PPIE): Recounting the untold stories of breast cancer patient experiences Open
Introduction Breast cancer remains a prevalent disease in women worldwide. Though significant advancements in the standard of care for breast cancer have contributed to improved patient survival and quality of life, a breast cancer diagnos…
View article: Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II
Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II Open
Background: Tyrosine kinase inhibitors (TKIs) have dramatically improved cancer treatment but are known to cause cardiotoxicity. The pathophysiological consequences of TKI therapy are likely to manifest across different cell types of the h…
View article: MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer
MYC regulates fatty acid metabolism through a multigenic program in claudin-low triple negative breast cancer Open
Background Recent studies have suggested that fatty acid oxidation (FAO) is a key metabolic pathway for the growth of triple negative breast cancers (TNBCs), particularly those that have high expression of MYC. However, the underlying mech…
View article: Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells
Multi-Omics Studies Demonstrate Toxoplasma gondii-Induced Metabolic Reprogramming of Murine Dendritic Cells Open
Toxoplasma gondii is capable of actively invading almost any mammalian cell type including phagocytes. Early events in phagocytic cells such as dendritic cells are not only key to establishing parasite infection, but conversely play…
View article: Raw RNA sequencing data for Hargrave et al 2019
Raw RNA sequencing data for Hargrave et al 2019 Open
Raw RNA sequencing dataset spilt into files comparing either UN with LPS or Toxoplasma gondii and also LPS with Toxoplasma gondii. Each comparison folder should have gene expression tables of all genes, gene expression table of just signif…
View article: Signal Transduction and Smooth Muscle
Signal Transduction and Smooth Muscle Open
All hollow organs, such as blood vessels, the gastrointestinal tract, airways, male and female reproductive systems, and the urinary bladder are primarily composed of smooth muscle. Such organs regulate flow, propulsion and mixing of lumin…
View article: RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry
RPGR protein complex regulates proteasome activity and mediates store-operated calcium entry Open
Ciliopathies are a group of genetically heterogeneous disorders, characterized by defects in cilia genesis or maintenance. Mutations in the RPGR gene and its interacting partners, RPGRIP1 and RPGRIP1L, cause ciliopathi…
View article: P26 Inhibition of mitochondrial fission decreased endothelial cell von willebrand factor content and gap junction communication
P26 Inhibition of mitochondrial fission decreased endothelial cell von willebrand factor content and gap junction communication Open
The endothelium is the innermost layer of vascular cells, with a central role in maintaining vascular health. Within endothelial cells, mitochondria play important roles in calcium homeostasis, reactive oxygen species production and, to a …
View article: Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle
Age decreases mitochondrial motility and increases mitochondrial size in vascular smooth muscle Open
Key points Age is proposed to be associated with altered structure and function of mitochondria; however, in fully‐differentiated cells, determining the structure of more than a few mitochondria at a time is challenging. In the present stu…
View article: Erratum to: Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture
Erratum to: Purification of Cyclic GMP-AMP from Viruses and Measurement of Its Activity in Cell Culture Open
View article: Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle
Calcium Mobilization via Intracellular Ion Channels, Store Organization and Mitochondria in Smooth Muscle Open
In smooth muscle, Ca2+ release from the internal store into the cytoplasm occurs via inositol trisphosphate (IP3R) and ryanodine receptors (RyR). The internal Ca2+ stores containing IP3R and RyR may be arranged as multiple separate compart…
View article: Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension
Flicker-assisted localization microscopy reveals altered mitochondrial architecture in hypertension Open
Mitochondrial morphology is central to normal physiology and disease development. However, in many live cells and tissues, complex mitochondrial structures exist and morphology has been difficult to quantify. We have measured the shape of …
View article: Synthesis of an azido-tagged low affinity ratiometric calcium sensor
Synthesis of an azido-tagged low affinity ratiometric calcium sensor Open