Explanipedia

Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease Open

Yue Feng, Monica M. Goncalves, Yulia Jitkova, Alexander F. A. Keszei, Yongran Yan , et al. · 2025

ClpXP is a two-component mitochondrial matrix protease. The caseinolytic mitochondrial matrix peptidase chaperone subunit X (ClpX) recognizes and translocates protein substrates into the degradation chamber of the caseinolytic protease P (…

From freeze to function: optimised cryopreservation and mitochondrial analysis workflow for skeletal muscle biopsies Open

Maheen Wahid, Graeme MacKenzie, Liam M. Rooney, Justin C. Greig, Gail McConnell , et al. · 2024

Background Skeletal muscle biopsies are valuable in clinical and research settings, contributing to advancements in diagnosing, understanding, and treating muscle-related conditions. Traditional freezing methods often cause artefacts mista…

From Freeze to Function: Optimised Cryopreservation and Mitochondrial Analysis Workflow for Skeletal Muscle Biopsies Open

Maheen Wahid, Graeme MacKenzie, Liam M. Rooney, Justin C. Greig, Gail McConnell , et al. · 2024

Background Skeletal muscle biopsies are valuable in clinical and research settings, contributing to advancements in diagnosing, understanding, and treating muscle-related conditions. Traditional freezing methods often cause artefacts mista…

A novel 3D imaging approach for quantification of GLUT4 levels across the intact myocardium Open

Angéline Geiser, Susan Currie, Hadi Al‐Hasani, Alexandra Chadt, Gail McConnell , et al. · 2024

Cellular heterogeneity is a well-accepted feature of tissues, and both transcriptional and metabolic diversity have been revealed by numerous approaches, including optical imaging. However, the high magnification objective lenses needed fo…

BS42 CaMKII augments ros and Ca2+ entry processes in female cardiac fibroblasts in hyperglycaemic and hypertensive conditions Open

Zainab Omotola Olatunji, Susan Currie, Niall Macquaide · 2024

Introduction Heart Failure with preserved Ejection Fraction (HFpEF) affects over 50% of patients with HF, majority of whom are females with conditions such as hypertension, obesity and diabetes. Our in vivo animal models of these condition…

BS15 Acute effects of cobalt on calcium handling in cardiac myocytes Open

Miren Cameron Ruiz, Zainab Omotola Olatunji, Niall Macquaide, Susan Currie · 2024

Introduction In recent years, Cobalt has been used as a component in metal-on-metal (MoM) bearings for orthopaedic knee and hip replacements, due to abnormal wear and corrosion they can result in the release of cobalt ions (Co2+). Chronic …

RWOP3 Cardiac fibroblasts modulate Ca<sup>2+</sup> signalling in cardiac myocytes under hyperglycaemic and hypertensive conditions Open

Zainab Omotola Olatunji, Susan Currie, Niall Macquaide · 2024

Heart Failure with preserved Ejection Fraction (HFpEF), is a multifactorial disease associated with hypertension, diabetes and obesity, and is predominantly observed in females. HFpEF results in a slowly relaxing, fibrotic myocardium, and…

A Novel 3D Imaging Approach for Quantification of GLUT4 Levels across the Intact Myocardium Open

Angéline Geiser, Susan Currie, Hadi Al‐Hasani, Alexandra Chadt, Gail McConnell , et al. · 2024

Cellular heterogeneity is a well-accepted feature of tissues, and both transcriptional and metabolic diversity have been revealed by numerous approaches, including optical imaging. However, the high magnification objective lenses needed fo…

Extracellular vesicles in organ and systems function in health and disease Open

Susan Currie, Harold D. Schultz · 2023

This special issue of The Journal of Physiology entitled ‘Extracellular vesicles in organ and systems function in health and disease’ originated from a focused symposium held at Experimental Biology in April 2021 sponsored by The Physiolog…

18 Effects of acute and chronic cobalt treatment on adult rat cardiomyocyte calcium handling Open

Zainab Omotola Olatunji, Sandy MacMillan, Miren Cameron-Ruiz, Zainab Y Bosakhar, Graeme MacKenzie , et al. · 2023

Patients with cobalt-chromium hip arthroplasties display increased cobalt levels in circulation. Elevated cobalt has been linked to cardiomyopathy, yet the mechanisms underlying cobalt-induced pathology remain unknown. Here, we have exami…

11 Cardiac function is compromised in patients with elevated blood cobalt levels secondary to metal-on-metal hip implants Open

Mark Jenkinson, Dominic Meek, Sandy MacMillan, Rothwelle J. Tate, M.H. Grant , et al. · 2023

Elevated blood cobalt secondary to metal-on-metal (MoM) hip arthroplasties has been shown to be a risk factor for developing cardiovascular complications including cardiomyopathy. Published case reports document cardiomyopathy in patients…

The activist life of Dr Janet Irwin and my activist response in researching and writing her story Open

Susan Currie · 2023

My PhD thesis, entitled ‘The activist life of Dr Janet Irwin, and my activist response in researching and writing her story consists of a biography, ‘A Prescription for Action: the life of Dr Janet Irwin, and an exegesis, ‘Biography, motiv…

Editorial: Arteriogenesis and Collateral Remodelling in Ischaemic Disease Open

Junxi Wu, Dongxing Zhu, Susan Currie · 2022

EDITORIAL article Front. Cardiovasc. Med., 15 June 2022Sec. Atherosclerosis and Vascular Medicine https://doi.org/10.3389/fcvm.2022.916218

Cobalt-induced cardiomyopathy – do circulating cobalt levels matter? Open

Mark R. J. Jenkinson, R.M.D. Meek, Rothwelle J. Tate, Sandy MacMillan, M.H. Grant , et al. · 2021

Elevated levels of circulating cobalt ions have been linked with a wide range of systemic complications including neurological, endocrine, and cardiovascular symptoms. Case reports of patients with elevated blood cobalt ions have described…

Sunitinib and Imatinib Display Differential Cardiotoxicity in Adult Rat Cardiac Fibroblasts That Involves a Role for Calcium/Calmodulin Dependent Protein Kinase II Open

Calum J. McMullen, Susan Chalmers, Rachael Wood, Margaret Cunningham, Susan Currie · 2021

Background: Tyrosine kinase inhibitors (TKIs) have dramatically improved cancer treatment but are known to cause cardiotoxicity. The pathophysiological consequences of TKI therapy are likely to manifest across different cell types of the h…

52 Optimisation of a cell-based model for the characterisation of novel drug-free stent coatings Open

Daniel Longhorn, Susan Currie, Christopher McCormick · 2019

Current pharmacological approaches aimed at improving stent designs are limited by their inability to reduce endothelial damage following stent placement and improve healing. Here, we consider in vitro approaches that could be used to ass…

Cobalt Administration Causes Reduced Contractility with Parallel Increases in TRPC6 and TRPM7 Transporter Protein Expression in Adult Rat Hearts Open

Sarunya Laovitthayanggoon, Catherine Henderson, Claire McCluskey, Margaret MacDonald, Rothwelle J. Tate , et al. · 2018

Exposure to circulating cobalt (Co²⁺) in patients with metal-on-metal orthopaedic hip implants has been linked to cardiotoxicity but the underlying mechanism(s) remain undefined. The aim of the current study was to examine the e…

12 Anti-cancer tyrosine kinase inhibitors increase oxidative stress in primary cardiac fibroblasts Open

CJ McMullen, C McCluskey, Su-Jeong Kim, S Laovitthayanggoon, M MacDonald , et al. · 2018

Anti-cancer tyrosine kinase inhibitors (TKI) are known to exert cardiotoxicity that can result in heart failure. Here we have used primary adult rat cardiac fibroblasts (CFs) to examine whether imatinib and sunitinib (both TKIs) increase o…

6 Parallel assessment of cell viability in cardiac and cancer cells following treatment with sunitinib Open

D.J. McBride, Abdulfattah Y. Alhazmi, Sarunya Laovitthayanggoon, Marie Boyd, Susan Currie · 2018

Various cardiopathological effects have been observed following chemotherapy treatment in cancer patients, due to anti-cancer drug-induced cardiotoxicity (CTX). A retrospective study of cancer survivors reported a 50% and 10% incidence of …

Supplementary Material for: Changes in IP3 Receptor Expression and Function in Aortic Smooth Muscle of Atherosclerotic Mice Open

Marie‐Ann Ewart, Azizah Ugusman, Anisha Vishwanath, Tarek Almabrouk, Husam Alganga , et al. · 2017

Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that rela…

Changes in IP3 Receptor Expression and Function in Aortic Smooth Muscle of Atherosclerotic Mice Open

Marie‐Ann Ewart, Azizah Ugusman, Anisha Vishwanath, Tarek Almabrouk, Husam Alganga , et al. · 2017

Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that rela…

Conference Calendar Open

Paolo Angeli, Karolina E. Zaborska, Gillian Edwards, Clare Austin, Mark Wareing , et al. · 2017

Supplementary Material for: Changes in IP3 Receptor Expression and Function in Aortic Smooth Muscle of Atherosclerotic Mice Open

Marie‐Ann Ewart, Azizah Ugusman, Anisha Vishwanath, Almabrouk T.A.M., Husam Alganga , et al. · 2017

Peroxynitrite is an endothelium-independent vasodilator that induces relaxation via membrane hyperpolarization. The activation of IP3 receptors triggers the opening of potassium channels and hyperpolarization. Previously we found that rela…

Effects of acute and chronic sunitinib treatment on cardiac function and calcium/calmodulin‐dependent protein kinase <span>II</span> Open

Laura Mooney, Matthew Skinner, Susan J. Coker, Susan Currie · 2015

Background and Purpose Calcium/calmodulin‐dependent protein kinase II δ ( CaMKII δ) is an important regulator of cardiac contractile function and dysfunction and may be an unwanted secondary target for anti‐cancer drugs such as sunitinib a…

Improving arteriovenous fistula patency: Transdermal delivery of diclofenac reduces cannulation-dependent neointimal hyperplasia via AMPK activation Open

Mark G. MacAskill, David G. Watson, Marie‐Ann Ewart, Roger M. Wadsworth, Andrew Jackson , et al. · 2015

Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy Open

Yuan Yan Sin, Tamara P. Martin, Lauren Wills, Susan Currie, George S. Baillie · 2015

These results identify a new signaling complex that is pivotal to pathological remodelling of the heart that could be targeted therapeutically.

Susan Currie YOU? Author Swipe