Jack A. Yanovski
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View article: The Physiology Of the WEight Reduced State (POWERS) study: overview and study design
The Physiology Of the WEight Reduced State (POWERS) study: overview and study design Open
Obesity is a multifactorial disease caused by physiological and environmental factors. Adults who have obesity are at increased risk for several additional chronic and infectious diseases, resulting in reduced life expectancy, compared to …
View article: Components of Adolescent Behavioural Interventions With Eating Disorder Outcomes: Systematic Review With Intervention Mapping
Components of Adolescent Behavioural Interventions With Eating Disorder Outcomes: Systematic Review With Intervention Mapping Open
Objective To understand delivery features and intervention strategies of adolescent weight management interventions which may influence eating disorder risk. Methods Systematic searches in four databases and two trial registries to identif…
View article: The Physiology Of the WEight Reduced State (POWERS) study: assessing energy balance
The Physiology Of the WEight Reduced State (POWERS) study: assessing energy balance Open
Background/objectives We provide the rationale for and description of energy balance measures (i.e., energy intake and energy expenditure) in The P hysiology O f the WE ight R educed S tate (POWERS) study which aims to understand the contr…
View article: MON-724 Effect Of CDD866, An Anti-activin Type II Receptor Antibody, On The Melanocortin 3 Receptor (MC3R) Deficiency Obesity Phenotype
MON-724 Effect Of CDD866, An Anti-activin Type II Receptor Antibody, On The Melanocortin 3 Receptor (MC3R) Deficiency Obesity Phenotype Open
Disclosure: E.A. Jansujwicz: None. T.P. Patel: None. D.M. Elizondo: None. B.T. Cole: None. J.A. Yanovski: Versanis Bio, Inc (CRADA). The melanocortin 3 receptor (MC3R) plays an important role in energy homeostasis. Mice with global MC3R de…
View article: OR35-07 The Glycemic Outcomes of Diazoxide Choline Extended-Release (DCCR) Tablets for Administered for Hyperphagia in Individuals with Prader-Willi Syndrome Over 4 Years
OR35-07 The Glycemic Outcomes of Diazoxide Choline Extended-Release (DCCR) Tablets for Administered for Hyperphagia in Individuals with Prader-Willi Syndrome Over 4 Years Open
Disclosure: A.H. Shoemaker: Soleno Therapeutics, Inc. J.A. Yanovski: Soleno Therapeutics, Inc. E.F. Gevers: Soleno Therapeutics, Inc. K.S. Obrynba: Soleno Therapeutics, Inc. M.D. Lah: Soleno Therapeutics, Inc. P. Salehi: Soleno Therapeutic…
View article: MON-662 Characterization of Peripheral Edema in Individuals with Prader-Willi Syndrome During Long-term Administration of Diazoxide Choline Extended-Release Tablet (DCCR) Over 4.5 Years
MON-662 Characterization of Peripheral Edema in Individuals with Prader-Willi Syndrome During Long-term Administration of Diazoxide Choline Extended-Release Tablet (DCCR) Over 4.5 Years Open
Disclosure: A.H. Shoemaker: Soleno Therapeutics, Inc. J.A. Yanovski: Soleno Therapeutics, Inc. K.S. Obrynba: Soleno Therapeutics, Inc. M. Lah: Soleno Therapeutics, Inc. P. Salehi: Soleno Therapeutics, Inc. S. Ballal: Soleno Therapeutics, I…
View article: SUN-669 Effect Of In Vivo Myeloid Cell Tgm2 Silencing On Diet-induced Obesity, Metabolism, And Inflammation
SUN-669 Effect Of In Vivo Myeloid Cell Tgm2 Silencing On Diet-induced Obesity, Metabolism, And Inflammation Open
Disclosure: B.T. Cole: None. D.M. Elizondo: None. T.P. Patel: None. E. Jansujwicz: None. J.A. Yanovski: None. Transglutaminase 2 (TGM2) is the most abundantly expressed enzyme of its group, which catalyzes calcium ion dependent post-transl…
View article: Improving the diagnosis of hyperphagia in melanocortin‐4 receptor pathway diseases
Improving the diagnosis of hyperphagia in melanocortin‐4 receptor pathway diseases Open
Characteristics of hyperphagia include heightened and prolonged hunger, longer time to satiation, shorter duration of satiety, severe preoccupation with food (i.e., hyperphagic drive), abnormal food‐seeking behaviors, and distress or funct…
View article: Hepatic MC3R is a regulator of lipid droplet autophagy and liver steatosis
Hepatic MC3R is a regulator of lipid droplet autophagy and liver steatosis Open
Intrahepatic triglyceride breakdown and recycling occur through lipolysis and lipid droplet (LD) macroautophagy/autophagy to regulate systemic fat partitioning. We recently demonstrated that MC3R is important for hepatic autophagy and peri…
View article: Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity
Melanocortin 3 receptor regulates hepatic autophagy and systemic adiposity Open
Systemic lipid homeostasis requires hepatic autophagy, a major cellular program for intracellular fat recycling. Here, we find melanocortin 3 receptor (MC3R) regulates hepatic autophagy in addition to its previously established CNS role in…
View article: Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway–Associated Disease: A Roundtable Summary
Defining Hyperphagia for Improved Diagnosis and Management of MC4R Pathway–Associated Disease: A Roundtable Summary Open
Purpose of review Hyperphagia is a condition associated with rare obesity-related diseases, presenting as a pathologic, insatiable hunger accompanied by abnormal food-seeking behaviors. In October 2023, a group of researchers and clinician…
View article: Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake
Predictive equation derived from 6,497 doubly labelled water measurements enables the detection of erroneous self-reported energy intake Open
Nutritional epidemiology aims to link dietary exposures to chronic disease, but the instruments for evaluating dietary intake are inaccurate. One way to identify unreliable data and the sources of errors is to compare estimated intakes wit…
View article: A Pilot Randomized Control Trial Testing a Smartphone-Delivered Food Attention Retraining Program in Adolescent Girls with Overweight or Obesity
A Pilot Randomized Control Trial Testing a Smartphone-Delivered Food Attention Retraining Program in Adolescent Girls with Overweight or Obesity Open
Background/Objectives: Attention bias (AB) toward food is associated with obesity, but it is unclear if programs designed to reduce AB can impact adolescents’ eating behavior. We investigated whether a two-week, smartphone-delivered attent…
View article: 6649 Associations of Fibroscan Results with Body Composition and Laboratory Measures in Patients with Obesity and Inflammation
6649 Associations of Fibroscan Results with Body Composition and Laboratory Measures in Patients with Obesity and Inflammation Open
Disclosure: A. Lyman: None. E. Nwosu: None. H.K. Gopalakrishna: None. Y. Rotman: None. N. Abdul Majeed: None. J. Lazareva: None. S.M. Brady: None. A.P. Demidowich: Grant Recipient; Self; Dexcom, Inc. J.A. Yanovski: Grant Recipient; Self; S…
View article: 7519 Withdrawal of DCCR (Diazoxide Choline) Extended-Release Tablets Worsens Hyperphagia and Increases Weight and BMI in a 16-week Double-blind, Placebo-controlled, Randomized Withdrawal Period in Patients with Prader Willi Syndrome
7519 Withdrawal of DCCR (Diazoxide Choline) Extended-Release Tablets Worsens Hyperphagia and Increases Weight and BMI in a 16-week Double-blind, Placebo-controlled, Randomized Withdrawal Period in Patients with Prader Willi Syndrome Open
Disclosure: E.F. Gevers: Advisory Board Member; Self; Pfizer, Inc., Soleno. Research Investigator; Self; Soleno Therapeutics, Inc.. Speaker; Self; Pfizer, Inc., Novo Nordisk, Soleno Therapeutics, Inc. J.L. Miller: Research Investigator; Se…
View article: An open‐label 16‐week study of liraglutide in adolescents with obesity post‐sleeve gastrectomy
An open‐label 16‐week study of liraglutide in adolescents with obesity post‐sleeve gastrectomy Open
Summary Background Up to 50% of adolescents who undergo metabolic and bariatric surgery (MBS) have obesity 3 years post‐MBS, placing them at continued risk for the consequences of obesity. Objectives We conducted an open‐label, 16‐week pil…
View article: A systematic review and meta‐analysis of loss‐of‐control eating in relation to cardiometabolic health components and inflammatory markers
A systematic review and meta‐analysis of loss‐of‐control eating in relation to cardiometabolic health components and inflammatory markers Open
Summary Introduction Loss‐of‐control (LOC) eating, or the subjective experience of being unable to stop eating, is a hallmark feature of binge‐eating episodes, which are also characterized by consuming an unusually large amount of food. Ho…
View article: Prediction of resting energy expenditure for adolescents with severe obesity: A multi‐centre analysis
Prediction of resting energy expenditure for adolescents with severe obesity: A multi‐centre analysis Open
Summary Background and Objectives Resting energy expenditure (REE) assessments can help inform clinical treatment decisions in adolescents with elevated body mass index (BMI), but current equations are suboptimal for severe obesity. We dev…
View article: Lower subjective social status is associated with increased adiposity and self-reported eating in the absence of hunger due to negative affect among children reporting teasing distress
Lower subjective social status is associated with increased adiposity and self-reported eating in the absence of hunger due to negative affect among children reporting teasing distress Open
Objectives Low social standing and teasing are independently associated with increased body mass index (BMI) and overeating in children. However, children with low social status may be vulnerable to teasing. Methods We tested the statistic…
View article: Emotional dysregulation moderates the relation between perceived stress and emotional eating in adolescent military dependents
Emotional dysregulation moderates the relation between perceived stress and emotional eating in adolescent military dependents Open
Objective Adolescent children of US service members (i.e., military‐dependent youth) face unique stressors that increase risk for various forms of disinhibited eating, including emotional eating. Difficulties with adaptively responding to …