Susan L. Furth
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View article: Association of NT-proBNP With CKD Progression in the Chronic Kidney Disease in Children Study
Association of NT-proBNP With CKD Progression in the Chronic Kidney Disease in Children Study Open
View article: “Pilot pragmatic clinical trial of iron therapy in children with anemia of chronic kidney disease (FeTCh-CKD)” — authors’ reply
“Pilot pragmatic clinical trial of iron therapy in children with anemia of chronic kidney disease (FeTCh-CKD)” — authors’ reply Open
View article: Quantifying “Medical Renal Disease”: A Pediatric Pilot Study Using Ultrasound Radiomics for Differentiating Acute Kidney Injury and Chronic Kidney Disease
Quantifying “Medical Renal Disease”: A Pediatric Pilot Study Using Ultrasound Radiomics for Differentiating Acute Kidney Injury and Chronic Kidney Disease Open
Background: Differentiating acute kidney injury (AKI) from chronic kidney disease (CKD) in children remains a critical unmet need due to the limitations of current clinical and biochemical markers. Conventional ultrasound lacks the sensiti…
View article: Metabolic Acidosis and Cardiovascular Disease Risk in Children with CKD
Metabolic Acidosis and Cardiovascular Disease Risk in Children with CKD Open
Key Points Metabolic acidosis may be associated with adverse cardiovascular disease risk. Prospective studies of the benefit of alkali therapy on cardiovascular disease risk are needed. Background The link between metabolic acidosis (MA) a…
View article: COVID-19 Associated Worry and Emotional Distress in Youth and Young Adults with Chronic Kidney Disease
COVID-19 Associated Worry and Emotional Distress in Youth and Young Adults with Chronic Kidney Disease Open
The COVID-19 (C19) pandemic impacted youth mental/behavioral health with a 25% increase in prevalence of anxiety and depression worldwide. Little is known about the emotional impact of C19 for children with Chronic Kidney Disease (CKD).
View article: Hypertension, proteinuria, and RAAS inhibition use in children with systemic lupus erythematosus: Data from a multi-institutional pediatric learning health system
Hypertension, proteinuria, and RAAS inhibition use in children with systemic lupus erythematosus: Data from a multi-institutional pediatric learning health system Open
Objectives To assess the potential of a multi-institutional pediatric learning health system for comparative effectiveness research in pediatric-onset systemic lupus erythematosus (SLE), we characterized renin angiotensin aldosterone syste…
View article: Tacrolimus IPV Group Membership Does Not Consistently Track With Electronically Monitored or Self-reported Adherence in Adolescent and Young Adult Kidney Transplant Recipients
Tacrolimus IPV Group Membership Does Not Consistently Track With Electronically Monitored or Self-reported Adherence in Adolescent and Young Adult Kidney Transplant Recipients Open
Background. High intrapatient variability (IPV) of tacrolimus trough concentrations (SD ≥ 2, coefficient of variation (CV%) ≥ 30) is associated with rejection and graft loss and may indicate nonadherence. However, the association between t…
View article: Effectiveness of Allopurinol on Uric Acid and Pediatric Chronic Kidney Disease Severity in the Chronic Kidney Disease in Children Study
Effectiveness of Allopurinol on Uric Acid and Pediatric Chronic Kidney Disease Severity in the Chronic Kidney Disease in Children Study Open
View article: Patient and caregiver perspectives on mental health in children and adolescents with chronic kidney disease
Patient and caregiver perspectives on mental health in children and adolescents with chronic kidney disease Open
Rationale & Objective Children and adolescents with chronic kidney disease (CKD) are at risk of depression and other mental health conditions, which can impair quality of life, the capacity for self-management and adherence to treatment, a…
View article: Culturally Tailored Messages and Trial Registry Enrollment
Culturally Tailored Messages and Trial Registry Enrollment Open
Importance Marginalized populations have lower levels of clinical trial representation than other populations. Tailoring recruitment materials and providing incentives may improve representation. Objective To determine whether culturally t…
View article: Clinical characteristics and favorable treatment responses of recurrent focal segmental glomerulosclerosis or steroid-resistant nephrotic syndrome in children after kidney transplantation
Clinical characteristics and favorable treatment responses of recurrent focal segmental glomerulosclerosis or steroid-resistant nephrotic syndrome in children after kidney transplantation Open
View article: Psychotropic Medication Usage in Pediatric CKD: Reporting from the CKD in Children Cohort
Psychotropic Medication Usage in Pediatric CKD: Reporting from the CKD in Children Cohort Open
Key Points Psychotropic medication use is prevalent in the pediatric CKD population. Central nervous system stimulant usage was more common in male patients, and antidepressant usage was more frequently reported at follow-up visits during …
View article: Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD
Longitudinal Plasma Metabolome Patterns and Relation to Kidney Function and Proteinuria in Pediatric CKD Open
Key Points Longitudinal untargeted metabolomics. Children with CKD have a circulating metabolome that changes over time. Background Understanding plasma metabolome patterns in relation to changing kidney function in pediatric CKD is import…
View article: Consistency of metabolite associations with measured glomerular filtration rate in children and adults
Consistency of metabolite associations with measured glomerular filtration rate in children and adults Open
Background There is interest in identifying novel filtration markers that lead to more accurate GFR estimates than current markers (creatinine and cystatin C) and are more consistent across demographic groups. We hypothesize that large-sca…
View article: Capacity for the management of kidney failure in the International Society of Nephrology North America and the Caribbean region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA)
Capacity for the management of kidney failure in the International Society of Nephrology North America and the Caribbean region: report from the 2023 ISN Global Kidney Health Atlas (ISN-GKHA) Open
View article: A<i>Drosophila</i>model to screen Alport syndrome<i>COL4A5</i>variants for their functional pathogenicity
A<i>Drosophila</i>model to screen Alport syndrome<i>COL4A5</i>variants for their functional pathogenicity Open
Alport syndrome is a hereditary chronic kidney disease, attributed to rare pathogenic variants in either of three collagen genes ( COL4A3/4/5 ) with most localized in COL4A5 . Trimeric type IV Collagen α3α4α5 is essential for the glomerula…
View article: Adenotonsillectomy for Snoring and Mild Sleep Apnea in Children
Adenotonsillectomy for Snoring and Mild Sleep Apnea in Children Open
Importance The utility of adenotonsillectomy in children who have habitual snoring without frequent obstructive breathing events (mild sleep-disordered breathing [SDB]) is unknown. Objectives To evaluate early adenotonsillectomy compared w…
View article: Pubertal luteinizing hormone levels in children with chronic kidney disease and association with change in glomerular filtration rate
Pubertal luteinizing hormone levels in children with chronic kidney disease and association with change in glomerular filtration rate Open
View article: Evaluation of novel candidate filtration markers from a global metabolomic discovery for glomerular filtration rate estimation
Evaluation of novel candidate filtration markers from a global metabolomic discovery for glomerular filtration rate estimation Open
View article: Plasma Metabolomics of Dietary Intake of Protein-Rich Foods and Kidney Disease Progression in Children
Plasma Metabolomics of Dietary Intake of Protein-Rich Foods and Kidney Disease Progression in Children Open
View article: Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD
Circulating Metabolomic Associations with Neurocognitive Outcomes in Pediatric CKD Open
Background Children with CKD are at risk for impaired neurocognitive functioning. We investigated metabolomic associations with neurocognition in children with CKD. Methods We leveraged data from the Chronic Kidney Disease in Children (CKi…
View article: Associations between anemia and FGF23 in the CKiD study
Associations between anemia and FGF23 in the CKiD study Open
Background Fibroblast growth factor 23 (FGF23) is a bone-derived hormone that plays a central role in chronic kidney disease-mineral bone disorder and is associated with CKD progression and cardiovascular morbidity. Factors related to CKD-…
View article: Performance of GFR Estimating Equations in Young Adults
Performance of GFR Estimating Equations in Young Adults Open
View article: Association Between Dialysis Facility Ownership and Mortality Risk in Children With Kidney Failure
Association Between Dialysis Facility Ownership and Mortality Risk in Children With Kidney Failure Open
Importance In adults, treatment at profit dialysis facilities has been associated with a higher risk of death. Objective To determine whether profit status of dialysis facilities is associated with the risk of death in children with kidney…
View article: Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts
Regional Variation in Hemoglobin Distribution Among Individuals With CKD: the ISN International Network of CKD Cohorts Open
View article: Associations between collagen X biomarker and linear growth velocity in a pediatric chronic kidney disease cohort
Associations between collagen X biomarker and linear growth velocity in a pediatric chronic kidney disease cohort Open
View article: Antihypertensive medication nonadherence and target organ damage in children with chronic kidney disease
Antihypertensive medication nonadherence and target organ damage in children with chronic kidney disease Open
View article: Longitudinal changes of health-related quality of life in childhood chronic kidney disease
Longitudinal changes of health-related quality of life in childhood chronic kidney disease Open
View article: The Impact of Pediatric CKD on Educational and Employment Outcomes
The Impact of Pediatric CKD on Educational and Employment Outcomes Open
Key Points This study evaluates educational and employment outcomes in patients with pediatric kidney disease and assesses predictors of educational attainment and employment in young adulthood. Despite high rates of high school graduation…
View article: Descriptions and Determinants of N-Terminal Pro–B-Type Natriuretic Peptide in Pediatric CKD: The Chronic Kidney Disease in Children (CKiD) Study
Descriptions and Determinants of N-Terminal Pro–B-Type Natriuretic Peptide in Pediatric CKD: The Chronic Kidney Disease in Children (CKiD) Study Open