Explanipedia

Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis Open

Isaac Z Pope, Sidhant Chopra, Alexander Holmes, Shona M. Francey, Brian O’Donoghue , et al. · 2025

556. LONGITUDINAL CORTICAL THICKNESS CHANGES IN FIRST EPISODE PSYCHOSIS: A TRIPLE-BLIND RANDOMISED PLACEBO-CONTROLLED MRI STUDY Open

Sidhant Chopra, Alexander Holmes, Aaron Segal, Xuchen Zhang, S Francey , et al. · 2025

Background Changes in cortical thickness are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and have been shown to progress with ongoing illness. A major unresolved question concerns whether these cha…

Differential effects of illness and antipsychotics on cortical thinning in first episode psychosis Open

Sidhant Chopra, Alexander Holmes, Ashlea Segal, Xi-Han Zhang, Shona M. Francey , et al. · 2025

Introduction: Cortical grey matter loss is a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and has been shown to progress with ongoing illness. A major unresolved question concerns whether these change…

Maintaining family contact during COVID 19: Describing the experiences and needs of children with a family member in prison Open

Catherine Flynn, Susy Harrigan, Lorana Bartels, Susan Dennison · 2025

Prison visiting across the globe has been significantly affected in 2020 by the COVID-19 pandemic. By March 2020, prisons across the world began to limit or ban face-to-face visits, in an attempt to manage the health risks for a more vulne…

Brainwide Anatomical Connectivity and Prediction of Longitudinal Outcomes in Antipsychotic-Naïve First-Episode Psychosis Open

Sidhant Chopra, Priscila T. Levi, Alexander Holmes, Edwina R. Orchard, Ashlea Segal , et al. · 2024

Brainwide reductions of structural connectivity exist during the early stages of psychotic illness and cannot be attributed to antipsychotic medication. Moreover, baseline measures of structural connectivity can predict change in patient f…

Brain-wide Disruptions of Anatomical Connectivity in Antipsychotic-Naïve First Episode Psychosis Open

Sidhant Chopra, Priscila T. Levi, Alexander Holmes, Edwina R. Orchard, Ashlea Segal , et al. · 2023

OBJECTIVE Disruptions of axonal connectivity are thought to be a core pathophysiological feature of psychotic illness, but whether they are present early in the illness, prior to antipsychotic exposure, and whether they can predict clinica…

Network-Based Spreading of Gray Matter Changes Across Different Stages of Psychosis Open

Sidhant Chopra, Ashlea Segal, Stuart Oldham, Alexander Holmes, Kristina Sabaroedin , et al. · 2023

Importance Psychotic illness is associated with anatomically distributed gray matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown. Objective …

Caregiver views on father-child contact in prison during the COVID-19 pandemic: implications for the use of video visits Open

Helen Taylor, Catherine Flynn, Susy Harrigan, Lorana Bartels, Susan Dennison · 2023

It is generally understood that visits to see incarcerated family members are good for children, families and those in prison. Much research has focused on the impact of prison visits on children and incarcerated mothers, ‘parents’ as a ge…

Effects of risperidone/paliperidone versus placebo on cognitive functioning over the first 6 months of treatment for psychotic disorder: secondary analysis of a triple-blind randomised clinical trial Open

Kelly Allott, Hok Pan Yuen, Lara Baldwin, Brian O’Donoghue, Alex Fornito , et al. · 2023

Gradients of striatal function in antipsychotic-free first-episode psychosis and schizotypy Open

Marianne Oldehinkel, Jeggan Tiego, Kristina Sabaroedin, Sidhant Chopra, Shona M. Francey , et al. · 2023

Both psychotic illness and subclinical psychosis-like experiences (PLEs) have been associated with cortico-striatal dysfunction. This work has largely relied on a discrete parcellation of the striatum into distinct functional areas, but re…

Isolating the impact of antipsychotic medication on metabolic health: Secondary analysis of a randomized controlled trial of antipsychotic medication versus placebo in antipsychotic medication naïve first‐episode psychosis (the <span>STAGES</span> study) Open

Brian O’Donoghue, Kelly Allott, Susy Harrigan, Franco Scalzo, Janine Ward , et al. · 2022

Background Cardiovascular and metabolic diseases are the leading contributors to the early mortality associated with psychotic disorders. To date, it has not been possible to disentangle the effect of medication and non‐medication factors …

Antipsychotic Effects on Longitudinal Cognitive Functioning in First-Episode Psychosis: A randomised, triple-blind, placebo-controlled study Open

Kelly Allott, Hok Pan Yuen, Lara Baldwin, Brian O’Donoghue, Alex Fornito , et al. · 2022

Objective Cognitive impairment occurs in antipsychotic-naïve first-episode psychosis (FEP), but antipsychotics confound interpretation of the longitudinal course of cognition. The primary aim was to disentangle the effects of illness from …

Frontostriatothalamic effective connectivity and dopaminergic function in the psychosis continuum Open

Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk , et al. · 2022

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction is driven by aberrant bottom-up subcortical signalli…

Network-based spreading of grey matter changes across different stages of psychosis Open

Sidhant Chopra, Ashlea Segal, Stuart Oldham, Alexander Holmes, Kristina Sabaroedin , et al. · 2022

Importance Psychotic illness is associated with anatomically distributed grey matter reductions that can worsen with illness progression, but the mechanisms underlying the specific spatial patterning of these changes is unknown. Objective …

Contact experiences and needs of children of prisoners before and during COVID‐19: Findings from an Australian survey Open

Catherine Flynn, Lorana Bartels, Susan Dennison, Helen Taylor, Susy Harrigan · 2021

Most of the research examining children visiting a parent in prison indicates that visits have a positive impact on children's well‐being, their connection to the imprisoned parent and the parent themselves. However, the COVID‐19 pandemic …

Functional Connectivity in Antipsychotic-Treated and Antipsychotic-Naive Patients With First-Episode Psychosis and Low Risk of Self-harm or Aggression Open

Sidhant Chopra, Shona M. Francey, Brian O’Donoghue, Kristina Sabaroedin, Aurina Arnatkevičiūtė , et al. · 2021

ACTRN12607000608460.

Longitudinal Changes in Functional Connectivity in Antipsychotic-treated and Antipsychotic-naive Patients with First Episode Psychosis Open

Sidhant Chopra, Shona M. Francey, Brian O’Donoghue, Kristina Sabaroedin, Aurina Arnatkevičiūtė , et al. · 2021

Background Altered functional connectivity (FC) is a common finding in resting-state functional Magnetic Resonance Imaging (rs-fMRI) studies of people with psychosis, yet how FC disturbances evolve in the early stages of illness, and how a…

Effective Connectivity and Dopaminergic Function of Fronto-Striato-Thalamic Circuitry in First-Episode Psychosis, Established Schizophrenia, and Healthy Controls Open

Kristina Sabaroedin, Adeel Razi, Sidhant Chopra, Nancy Tran, Andrii Pozaruk , et al. · 2021

Dysfunction of fronto-striato-thalamic (FST) circuits is thought to contribute to dopaminergic dysfunction and symptom onset in psychosis, but it remains unclear whether this dysfunction is driven by aberrant bottom-up subcortical signalin…

Differentiating the effect of antipsychotic medication and illness on brain volume reductions in first-episode psychosis: A Longitudinal, Randomised, Triple-blind, Placebo-controlled MRI Study Open

Sidhant Chopra, Alex Fornito, Shona M. Francey, Brian O’Donoghue, Vanessa Cropley , et al. · 2021

Cognitive ability and metabolic physical health in first-episode psychosis Open

Sarah Whitson, Brian O’Donoghue, Robert Hester, Lara Baldwin, Susy Harrigan , et al. · 2021

Cognitive impairments are a core feature of first-episode psychosis (FEP), arising before illness onset and antipsychotic exposure. Individuals with chronic psychosis experience poorer physical health while taking antipsychotic medication,…

S166. EFFECTIVE CONNECTIVITY OF FRONTOSTRIATAL SYSTEMS IN FIRST-EPISODE PSYCHOSIS Open

Kristina Sabaroedin, Adeel Razi, Kevin Aquino, Sidhant Chopra, Amy Finlay , et al. · 2020

Background Neuroimaging studies have found dysconnectivity of frontostriatal circuits across a broad spectrum of psychotic symptoms. However, it is unknown whether dysconnectivity within frontostriatal circuits originates from disrupted bo…

Differentiating the Effect of Medication and Illness on Brain Volume Reductions in First-Episode Psychosis: A Longitudinal, Randomized, Triple-blind, Placebo-controlled MRI Study Open

Sidhant Chopra, Alex Fornito, Shona M. Francey, Brian O’Donoghue, Vanessa Cropley , et al. · 2020

Changes in brain volume are a common finding in Magnetic Resonance Imaging (MRI) studies of people with psychosis and numerous longitudinal studies suggest that volume deficits progress with illness duration. However, a major unresolved qu…

Youth Depression Alleviation with Anti-inflammatory Agents (YoDA-A): a randomised clinical trial of rosuvastatin and aspirin Open

Michael Berk, Mohammadreza Mohebbi, Olivia Dean, Sue Cotton, Andrew M. Chanen , et al. · 2020

Evaluation of the Homeless Youth Assistance Program: Final Report Open

David Taylor, Sangita Chakraborty, Jonathan Ng, Vanessa Rose, Alex Gyani , et al. · 2020

Psychosocial Intervention With or Without Antipsychotic Medication for First-Episode Psychosis: A Randomized Noninferiority Clinical Trial Open

Shona M. Francey, Brian O’Donoghue, Barnaby Nelson, Jessica Graham, Lara Baldwin , et al. · 2020

This triple-blind (participants, clinicians, and researchers) randomized controlled noninferiority trial examined whether intensive psychosocial intervention (cognitive-behavioral case management, CBCM) for first-episode psychosis (FEP) in…

O5.1. GREY MATTER BRAIN CHANGES IN MEDICATED AND UNMEDICATED FIRST EPISODE PSYCHOSIS: A RANDOMISED PLACEBO-CONTROLLED TRIAL Open

Sidhant Chopra, Alex Fornito, Shona M. Francey, Brian O’Donoghue, Barnaby Nelson , et al. · 2019

First episode psychosis (FEP) has been consistently associated with changes within grey matter. No prospective study to date has been able to distinguish the differential effects of antipsychotic medication from the natural progression of …

Latent growth curve modelling of positive and negative symptom trajectories in first-episode psychosis from baseline to long-term follow-up Open

Susy Harrigan · 2017

Perspectives of adults with cochlear implants on current CI services and daily life Open

Zheng Yen Ng, Brian Lamb, Susy Harrigan, Sue Archbold, Sheetal Athalye , et al. · 2016

This paper reports on a survey and interviews carried out with adults who have gone through the cochlear implantation pathway. It explores their experiences of current services, the assessment process for implantation, and the impact on th…

Creating Community for Early-Career Geoscientists Open

Wouter Berghuijs, Susy Harrigan, Evan L. Kipnis, Nilay Doğulu, Marius G. Floriancic , et al. · 2015

Student involvement in geoscience unions: A case study from hydrology

Youth Depression Alleviation‐Augmentation with an anti‐inflammatory agent (<span>YoDA‐A</span>): protocol and rationale for a placebo‐controlled randomized trial of rosuvastatin and aspirin Open

Amelia L. Quinn, Olivia Dean, Christopher G. Davey, Melissa Kerr, Susy Harrigan , et al. · 2015

Aim There is growing support for the role of inflammation and oxidative stress in the pathophysiology of major depressive disorder (MDD). This has led to the development of novel strategies targeting inflammation in the treatment of depres…

Susy Harrigan YOU? Author Swipe