Susan Malkiel
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View article: B lymphocytes in treatment-naive paediatric patients with lupus are epigenetically distinct from healthy children
B lymphocytes in treatment-naive paediatric patients with lupus are epigenetically distinct from healthy children Open
Background SLE is likely triggered by gene–environment interactions. We have shown that most SLE-associated haplotypes encompass genomic regions enriched for epigenetic marks associated with enhancer function in lymphocytes, suggesting gen…
View article: 301 The Lupus Risk Index (LRI) as a biomarker in patients with lupus nephritis
301 The Lupus Risk Index (LRI) as a biomarker in patients with lupus nephritis Open
Background Identification of prognostic and predictive biomarkers in lupus nephritis (LN) is an area of intense study and interest. Non-invasive laboratory markers that associate with the likelihood of responding to therapy and/or assess c…
View article: B lymphocytes in Treatment-Naïve Pediatric Lupus Patients are Epigenetically Distinct from Healthy Children
B lymphocytes in Treatment-Naïve Pediatric Lupus Patients are Epigenetically Distinct from Healthy Children Open
Background Systemic lupus erythematosus (SLE) is a complex disease likely triggered by gene-environment interactions. We have shown that most of the SLE-associated haplotypes encompass genomic regions enriched for epigenetic marks associat…
View article: FcγRIIB regulates autoantibody responses by limiting marginal zone B cell activation
FcγRIIB regulates autoantibody responses by limiting marginal zone B cell activation Open
FcγRIIB is an inhibitory receptor expressed throughout B cell development. Diminished expression or function is associated with lupus in mice and humans, in particular through an effect on autoantibody production and plasma cell (PC) diffe…
View article: Context-dependent induction of autoimmunity by TNF signaling deficiency
Context-dependent induction of autoimmunity by TNF signaling deficiency Open
TNF inhibitors are widely used to treat inflammatory diseases; however, 30%-50% of treated patients develop new autoantibodies, and 0.5%-1% develop secondary autoimmune diseases, including lupus. TNF is required for formation of germinal c…
View article: FcγRIIB regulates (auto)antibody responses by limiting marginal zone B cell activation
FcγRIIB regulates (auto)antibody responses by limiting marginal zone B cell activation Open
FcγRIIB is an inhibitory receptor expressed throughout B cell development. Diminished expression or function is associated with lupus in mice and humans, in particular through an effect on autoantibody production and plasma cell differenti…
View article: 1509 Differences in chromatin architecture pre- and post-induction therapy in pediatric lupus patients
1509 Differences in chromatin architecture pre- and post-induction therapy in pediatric lupus patients Open
Background Systemic lupus erythematosus (SLE) may be triggered by gene-environment interactions. Data remain scarce on how epigenetic variance contributes to disease risk in pediatric SLE (pSLE). Our objectives were to identify differences…
View article: Phase II Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis
Phase II Randomized Trial of Rituximab Plus Cyclophosphamide Followed by Belimumab for the Treatment of Lupus Nephritis Open
Objective To assess the safety, mechanism of action, and preliminary efficacy of rituximab followed by belimumab in the treatment of refractory lupus nephritis (LN). Methods In a multicenter, randomized, open‐label clinical trial, 43 patie…
View article: Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus
Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus Open
Plasma cells (PCs) are responsible for the production of protective antibodies against infectious agents but they also produce pathogenic antibodies in autoimmune diseases, such as systemic lupus erythematosus (SLE). Traditionally, high af…
View article: Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry
Checkpoints for Autoreactive B Cells in the Peripheral Blood of Lupus Patients Assessed by Flow Cytometry Open
Objective Antinuclear antibodies (ANAs) are diagnostic in several autoimmune disorders, yet the failure to achieve B cell tolerance in these diseases is still poorly understood. Although secreted ANAs detected by an indirect immunofluoresc…