Susan McLellan
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View article: A Descriptive Analysis of the Use of Various Therapeutics in a Cohort of COVID-19 Patients and the Influence of Media Coverage
A Descriptive Analysis of the Use of Various Therapeutics in a Cohort of COVID-19 Patients and the Influence of Media Coverage Open
Background: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) impacted the healthcare system immensely throughout 2020-2022. Treatment practices varied in Texas, as guidelines were in flux. As a result, a variety of therapeutics…
View article: Safety and immunogenicity of a delayed booster dose of the rVSVΔG-ZEBOV-GP vaccine for prevention of Ebola virus disease: a multicentre, open-label, phase 2 randomised controlled trial
Safety and immunogenicity of a delayed booster dose of the rVSVΔG-ZEBOV-GP vaccine for prevention of Ebola virus disease: a multicentre, open-label, phase 2 randomised controlled trial Open
The Division of Intramural Research and the Division of Clinical Research of the National Institute of Allergy and Infectious Diseases at the US National Institutes of Health, Canadian Immunization Research Network through the Public Healt…
View article: The alarmin IL-33 exacerbates pulmonary inflammation and immune dysfunction in SARS-CoV-2 infection
The alarmin IL-33 exacerbates pulmonary inflammation and immune dysfunction in SARS-CoV-2 infection Open
Dysregulated host immune responses contribute to disease severity and worsened prognosis in COVID-19 infection and the underlying mechanisms are not fully understood. In this study, we observed that IL-33, a damage-associated molecular pat…
View article: Schistosomiasis: An Unexpected Cause of Gastrointestinal Bleeding Revealed by Endoscopic Biopsy
Schistosomiasis: An Unexpected Cause of Gastrointestinal Bleeding Revealed by Endoscopic Biopsy Open
CASE REPORT A 28-year-old man from Equatorial Guinea presented with debilitating fatigue, persistent shortness of breath for the past year, and notable episodes of hematochezia and melena for the past week. Laboratory workup indicated the …
View article: Hydrogen Sulfide Ameliorates SARS-CoV-2-Associated Lung Endothelial Barrier Disruption
Hydrogen Sulfide Ameliorates SARS-CoV-2-Associated Lung Endothelial Barrier Disruption Open
Recent studies have confirmed that lung microvascular endothelial injury plays a critical role in the pathophysiology of COVID-19. Our group and others have demonstrated the beneficial effects of H2S in several pathological processes and p…
View article: Hydrogen Sulfide Ameliorates SARS-CoV-2–Associated Lung Endothelial Barrier Disruption
Hydrogen Sulfide Ameliorates SARS-CoV-2–Associated Lung Endothelial Barrier Disruption Open
Recent studies have confirmed that lung microvascular endothelial injury plays a critical role in the pathophysiology of COVID-19. Our group and others have demonstrated the beneficial effects of H2S in several pathological processes and p…
View article: Role of HMGB1 in the activation of innate immune responses during SARS-CoV-2 infection
Role of HMGB1 in the activation of innate immune responses during SARS-CoV-2 infection Open
The ongoing COVID-19 pandemic caused by SARS-CoV-2 has resulted in overwhelming number of deaths worldwide, affecting all age groups. Due to the emergence and rapid spread of SARS-CoV-2 variants and waning immunity in humans to current vac…
View article: Vaccination Decreases the Infectious Viral Load of Delta Variant SARS-CoV-2 in Asymptomatic Patients
Vaccination Decreases the Infectious Viral Load of Delta Variant SARS-CoV-2 in Asymptomatic Patients Open
The Delta variant of SARS-CoV-2 has caused many breakthrough infections in fully vaccinated individuals. While vaccine status did not generally impact the number of viral RNA genome copies in nasopharyngeal swabs of breakthrough patients, …
View article: Texas professionals are employing a one health approach to protect the United States against biosecurity threats
Texas professionals are employing a one health approach to protect the United States against biosecurity threats Open
Texas is a geographically large state with large human and livestock populations, many farms, a long coastal region, and extreme fluctuations in weather. During the last 15 years, the state of Texas has frequently suffered disasters or cat…
View article: Unraveling the Treatment Effect of Baricitinib on Clinical Progression and Resource Utilization in Hospitalized COVID-19 Patients: Secondary Analysis of the Adaptive COVID-19 Treatment Randomized Trial-2
Unraveling the Treatment Effect of Baricitinib on Clinical Progression and Resource Utilization in Hospitalized COVID-19 Patients: Secondary Analysis of the Adaptive COVID-19 Treatment Randomized Trial-2 Open
Background The Adaptive COVID Treatment Trial-2 (ACTT-2) found that baricitinib in combination with remdesivir therapy (BCT) sped recovery in hospitalized coronavirus disease 2019 (COVID-19) patients vs remdesivir monotherapy (RMT). We exa…
View article: Lassa Virus Infection: a Summary for Clinicians
Lassa Virus Infection: a Summary for Clinicians Open
We provide succinct summaries of medical countermeasures against LASV to give the busy clinician a rapid reference. Although there are no approved drugs or vaccines for LF, we provide condensed information from a literature review for meas…
View article: Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization
Deconstructing the Treatment Effect of Remdesivir in the Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1: Implications for Critical Care Resource Utilization Open
Background The Adaptive Coronavirus Disease 2019 (COVID-19) Treatment Trial-1 (ACTT-1) found that remdesivir therapy hastened recovery in patients hospitalized with COVID-19, but the pathway for this improvement was not explored. We invest…
View article: Synthetic protein antigens for COVID-19 diagnostics
Synthetic protein antigens for COVID-19 diagnostics Open
There is an urgent need for inexpensive, rapid and specific antigen-based assays to test for infection with SARS-CoV-2 and distinguish variants arising as the COVID-19 pandemic spreads. We have identified a small, synthetic protein (JS7), …
View article: Being Ready to Treat Ebola Virus Disease Patients
Being Ready to Treat Ebola Virus Disease Patients Open
As the outbreak of Ebola virus disease (EVD) in West Africa continues, clinical preparedness is needed in countries at risk for EVD (e.g., United States) and more fully equipped and supported clinical teams in those countries with epidemic…
View article: Hypercalcemia with invasive pulmonary papillomatosis and microinvasive squamous carcinoma
Hypercalcemia with invasive pulmonary papillomatosis and microinvasive squamous carcinoma Open
Juvenile respiratory papillomatosis is a rare pediatric disease in which benign papillomata develop in the respiratory tract, most commonly involving the larynx and tracheobronchial tree. Invasive pulmonary papillomatosis is an aggressive …
View article: Effectiveness of pessary and pelvic floor physiotherapy alone and in combination for management of stress and mixed urinary incontinence: a literature review
Effectiveness of pessary and pelvic floor physiotherapy alone and in combination for management of stress and mixed urinary incontinence: a literature review Open
: Stress urinary incontinence (SUI) affects 29–75% of women and can have a significant impact on quality of life. Pessaries are low-cost interventions that have been used since the 5th century BC. Pessaries can be used to conservatively ma…
View article: Ebola in the DRC one year later – Boiling the frog?
Ebola in the DRC one year later – Boiling the frog? Open
The outbreak of Ebola virus disease in the Democratic Republic of the Congo (DRC), of which the World Health Organization (WHO) was first notified on August 1, 2018, is now approaching the first anniversary of its initial detection. At the…
View article: Emerging Trends in Clinical Tropical Medicine Research
Emerging Trends in Clinical Tropical Medicine Research Open
The American Society for Tropical Medicine and Hygiene recently inaugurated an award for the best clinical research article published in the society’s journal in the previous year. This article summarizes both the process of selecting the …
View article: The Special Pathogens Research Network: Enabling Research Readiness
The Special Pathogens Research Network: Enabling Research Readiness Open
The 2013-2016 epidemic of Ebola virus disease (EVD) that originated in West Africa underscored many of the challenges to conducting clinical research during an ongoing infectious disease epidemic, both in the most affected countries of Gui…
View article: Evaluating Promising Investigational Medical Countermeasures: Recommendations in the Absence of Guidelines
Evaluating Promising Investigational Medical Countermeasures: Recommendations in the Absence of Guidelines Open
Emerging and re-emerging infectious diseases pose growing global public health threats. However, research on and development of medical countermeasures (MCMs) for such pathogens is limited by the sporadic and unpredictable nature of outbre…