Susan Pereira Ribeiro
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View article: Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis
Delineation of the Human Germinal Centre Immune Landscape Using Multiplex Imaging Analysis Open
Given the role of follicular immune dynamics, especially the germinal centre, for the development of pathogen‐specific antibodies, their in situ characterisation is of great importance. We have developed a multiplex immunofluorescence imag…
View article: TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size
TGF-β mediates epigenetic control of innate antiviral responses and SIV reservoir size Open
View article: Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Author Correction: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption Open
View article: The role of the HIV-1 gut reservoir in driving early cardiovascular events in people living with HIV
The role of the HIV-1 gut reservoir in driving early cardiovascular events in people living with HIV Open
People with HIV (PWH), even when well-controlled on antiretroviral therapy (ART), are at an increased risk for cardiovascular disease (CVD) and CVD events including sudden cardiac death and acute myocardial infarction (MI). While PWH may a…
View article: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption Open
View article: Pediatric immunotherapy and HIV control
Pediatric immunotherapy and HIV control Open
Purpose of review Highlighting opportunities/potential for immunotherapy by understanding dynamics of HIV control during pediatric HIV infection with and without antiretroviral therapy (ART), as modeled in Simian immunodeficiency virus (SI…
View article: Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2
Intestinal helminth infection impairs vaccine-induced T cell responses and protection against SARS-CoV-2 Open
SUMMARY Although vaccines have reduced COVID-19 disease burden, their efficacy in helminth infection endemic areas is not well characterized. We evaluated the impact of infection by Heligmosomoides polygyrus bakeri (Hpb), a murine intestin…
View article: Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption.
Dual blockade of IL-10 and PD-1 leads to control of SIV viral rebound following analytical treatment interruption. Open
HIV persistence during antiretroviral therapy (ART) is associated with heightened plasma IL-10 levels and the expression of the co-inhibitory receptor PD-1. We hypothesized that IL-10 and PD-1 blockade would synergize to boost immune funct…
View article: Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers
Carbohydrate ligand engagement with CD11b enhances differentiation of tumor-associated myeloid cells for immunotherapy of solid cancers Open
Background Efforts to modulate the function of tumor-associated myeloid cell are underway to overcome the challenges in immunotherapy and find a cure. One potential therapeutic target is integrin CD11b, which can be used to modulate the my…
View article: TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques
TREM2+ and interstitial-like macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques Open
View article: Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections
Repurposing BCL-2 and Jak 1/2 inhibitors: Cure and treatment of HIV-1 and other viral infections Open
B cell lymphoma 2 (BCL-2) family proteins are involved in the mitochondrial apoptotic pathway and are key modulators of cellular lifespan, which is dysregulated during human immunodeficiency virus type 1 (HIV-1) and other viral infections,…
View article: COVID-19 and Down syndrome: the spark in the fuel
COVID-19 and Down syndrome: the spark in the fuel Open
View article: Chronic Alcohol Exposure Among People Living with HIV Is Associated with Innate Immune Activation and Alterations in Monocyte Phenotype and Plasma Cytokine Profile
Chronic Alcohol Exposure Among People Living with HIV Is Associated with Innate Immune Activation and Alterations in Monocyte Phenotype and Plasma Cytokine Profile Open
Despite advances in antiretroviral therapy, chronic immune activation continues to be observed among individuals with well-controlled HIV viral loads, and is associated with non-AIDS defining morbidities among people living with HIV. Alcoh…
View article: Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection
Lymph node CXCR5+ NK cells associate with control of chronic SHIV infection Open
The persistence of virally infected cells as reservoirs despite effective antiretroviral therapy is a major barrier to an HIV/SIV cure. These reservoirs are predominately contained within cells present in the B cell follicles (BCFs) of sec…
View article: IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health
IFN-α blockade during ART-treated SIV infection lowers tissue vDNA, rescues immune function, and improves overall health Open
Type I IFNs (TI-IFNs) drive immune effector functions during acute viral infections and regulate cell cycling and systemic metabolism. That said, chronic TI-IFN signaling in the context of HIV infection treated with antiretroviral therapy …
View article: TGF-β Signaling, Senescence and Impaired Metabolism in Central Memory CD4 T Cells Promotes HIV Persistence
TGF-β Signaling, Senescence and Impaired Metabolism in Central Memory CD4 T Cells Promotes HIV Persistence Open
View article: TGF-β2 is Associated with Asymptomatic/Mild SARS-CoV-2 Infection During Pregnancy and Lower SARS-CoV-2 Viral Loads in vitro
TGF-β2 is Associated with Asymptomatic/Mild SARS-CoV-2 Infection During Pregnancy and Lower SARS-CoV-2 Viral Loads in vitro Open
View article: Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection
Immune mechanisms in cancer patients that lead to poor outcomes of SARS-CoV-2 infection Open
View article: TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques
TREM2+ and interstitial macrophages orchestrate airway inflammation in SARS-CoV-2 infection in rhesus macaques Open
The COVID-19 pandemic remains a global health crisis, yet, the immunopathological mechanisms driving the development of severe disease remain poorly defined. Here, we utilize a rhesus macaque (RM) model of SARS-CoV-2 infection to delineate…
View article: TGF-β associated senescence and impaired metabolism in central memory CD4 T cells promotes HIV persistence
TGF-β associated senescence and impaired metabolism in central memory CD4 T cells promotes HIV persistence Open
Current therapeutic interventions to eradicate latent HIV (“reservoir”) and restore immune function in ART-treated HIV infection have yet to show efficacy. To explore mechanisms of HIV persistence, we apply an integrated systems biology ap…
View article: Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART
Increased homeostatic cytokines and stability of HIV-infected memory CD4 T-cells identify individuals with suboptimal CD4 T-cell recovery on-ART Open
Clinical outcomes are inferior for individuals with HIV having suboptimal CD4 T-cell recovery during antiretroviral therapy (ART). We investigated if the levels of infection and the response to homeostatic cytokines of CD4 T-cell subsets c…
View article: A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates
A yeast-expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates Open
An adjuvanted monomeric RBD immunogen induces immunogenicity and protective immunity against SARS-CoV-2 in rhesus macaques.
View article: Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression
Single cell RNA sequencing of AML initiating cells reveals RNA-based evolution during disease progression Open
View article: “Go”, “No Go,” or “Where to Go”; does microbiota dictate T cell exhaustion, programming, and HIV persistence?
“Go”, “No Go,” or “Where to Go”; does microbiota dictate T cell exhaustion, programming, and HIV persistence? Open
Purpose of review People living with HIV who fail to fully reconstitute CD4 + T cells after combination antiretroviral therapy therapy (i.e. immune nonresponders or INRs) have higher frequencies of exhausted T cells are enriched in a small…
View article: IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence
IL-10 driven memory T cell survival and Tfh differentiation promote HIV persistence Open
Summary Mechanisms regulating HIV persistence are complex and not well understood. Increased IL-10 levels were positively associated with HIV reservoir in blood and lymph nodes (LN) of treated HIV aviremic individuals. In LNs, B cells, reg…
View article: Microbiome And Metabolome Driven Differentiation Of TGF-β Producing Tregs Leads to Senescence and HIV Latency
Microbiome And Metabolome Driven Differentiation Of TGF-β Producing Tregs Leads to Senescence and HIV Latency Open
View article: Microbiome and Metabolome driven differentiation of TGF-β producing Tregs leads to Senescence and HIV latency
Microbiome and Metabolome driven differentiation of TGF-β producing Tregs leads to Senescence and HIV latency Open
Summary Current therapeutic interventions to eradicate latent HIV (“reservoir”) and restore immune function in ART-treated HIV infection have yet to show efficacy. To explore mechanisms of HIV persistence, we apply an integrated systems bi…
View article: Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
Baricitinib treatment resolves lower-airway macrophage inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques Open
View article: Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques
Baricitinib treatment resolves lower airway inflammation and neutrophil recruitment in SARS-CoV-2-infected rhesus macaques Open
Effective therapeutics aimed at mitigating COVID-19 symptoms are urgently needed. SARS-CoV-2 induced hypercytokinemia and systemic inflammation are associated with disease severity. Baricitinib, a clinically approved JAK1/2 inhibitor with …
View article: Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes
Beta cell-specific CD8+ T cells maintain stem cell memory-associated epigenetic programs during type 1 diabetes Open