Susan K. Schultz
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Predictive modeling of initiation and delayed mental health contact for depression Open
Background Depression is prevalent among Operation Enduring Freedom and Operation Iraqi Freedom (OEF/OIF) Veterans, yet rates of Veteran mental health care utilization remain modest. The current study examined: factors in electronic health…
Mental health treatment utilization patterns among 108,457 Afghanistan and Iraq veterans with depression. Open
People with depression often underutilize mental health care. This study was conceived as a first step toward a clinical decision support tool that helps identify patients who are at higher risk of underutilizing care. The primary goals we…
Heterogeneity in 10-year course trajectories of moderate to severe major depressive disorder among veterans Open
Aims Epidemiological studies show that despite the episodic nature, the long-term trajectory of depression can be variable. This study evaluated the heterogeneity of 10-year trajectory of major depressive disorder (MDD) related service uti…
A phase IIb, open-label, randomized controlled dose ranging multi-centre trial to evaluate the safety, tolerability, pharmacokinetics and exposure-response relationship of different doses of delpazolid in combination with bedaquiline delamanid moxifloxacin in adult subjects with newly diagnosed, uncomplicated, smear-positive, drug-sensitive pulmonary tuberculosis Open
Background Linezolid is an effective, but toxic anti-tuberculosis drug that is currently recommended for the treatment of drug-resistant tuberculosis. Improved oxazolidinones should have a better safety profile, while preserving efficacy. …
Clustering patients with vascular cognitive impairment using quantitative magnetic resonance imaging data and a finite mixture model Open
Background Blood‐brain barrier (BBB) leakage is a marker of vascular cognitive impairment and dementia (VCID). The advance of in vivo imaging enabled us to quantify the degree of BBB transfer rates in VCID patients. However, a consensus ha…
Patients of Comprehensive Primary Care Physicians Receive Better Care and Have Better Outcomes: Findings from Ontario, Canada Open
CONTEXT: Comprehensiveness is a key attribute of primary care. In recent years many metrics have been developed to identify comprehensive primary care practice, but with limited understanding of their relationship with health care and outc…
Exploring the Longitudinal Work Patterns of Family Physicians From 2005-2019 – An Ontario Alberta Collaboration Open
CONTEXT: There is growing concern about the supply and distribution of Family Physicians (FPs) in Canada. With an aging FP workforce and preference for part-time practice, securing access to care for remains a dilemma for patients and fund…
The Value of Extracting Clinician-Recorded Affect for Advancing Clinical Research on Depression: Proof-of-Concept Study Applying Natural Language Processing to Electronic Health Records Open
Background Affective characteristics are associated with depression severity, course, and prognosis. Patients’ affect captured by clinicians during sessions may provide a rich source of information that more naturally aligns with the depre…
Hiding under the ROC Curve:Detection of Malicious Cyberattacks in EHR Data from Model Prediction Variance (Preprint) Open
BACKGROUND Machine learning models are increasingly being used in healthcare settings. If integrity of the data used to build these models is impacted by cybersecurity attacks, the results of these predictive models become questionable. OB…
Comparison of T<sub>1</sub>Rho MRI, Glucose Metabolism, and Amyloid Burden Across the Cognitive Spectrum: A Pilot Study Open
Higher T1rho values were associated with greater cognitive impairment and pathological burden. T1rho, a biomarker that varies according to a feature common to each cascade rather than one that is unique to a particular pathology, has the p…
Hemodynamic regulation of perivalvular endothelial gene expression prevents deep venous thrombosis Open
Deep venous thrombosis (DVT) and secondary pulmonary embolism cause approximately 100,000 deaths per year in the United States. Physical immobility is the most significant risk factor for DVT, but a molecular and cellular basis for this li…
Psychosis Due to Hypothyroidism: Are Antipsychotics Indicated? Open
Objective: To present a case of thyroid-related psychosis and review the literature to assess evidence regarding the use of antipsychotic medications in patients who develop this condition.Data Sources: The OVID database was utilized to se…
Perspectives on the Management of Vascular Depression Open
“Mr. A,” an 80-year-old married man, presents for his first psychiatric evaluation. He arrives punctually, carrying a manila folder containing documents summarizing his medication history and previous surgical procedures. He reports that t…
Early Phase PIB‐PET as a Surrogate for Global and Regional Cerebral Blood Flow Measures Open
BACKGROUND AND PURPOSE To explore the potential for simplified measures of [ 11 C]PIB uptake to serve as a surrogate for cerebral blood flow (CBF) measures, thereby, providing both pathological and functional information in the same scan. …
Machine learning for psychiatric patient triaging: an investigation of cascading classifiers Open
Objective Develop an approach, One-class-at-a-time, for triaging psychiatric patients using machine learning on textual patient records. Our approach aims to automate the triaging process and reduce expert effort while providing high class…
0161 Relationship Between Early Rest-Activity Cycle Disturbances (RACD) And 1-year Psychological Health Outcomes In VA TBI Model System Participants Open
Sleep-wake patterns are commonly disrupted following acute traumatic brain injury (TBI). Recent studies have characterized sleep-wake cycle disturbances and their association with poor outcomes during acute recovery. To date, no study has …
Factors Associated With Wandering Behaviors in Veterans With Mild Dementia: A Prospective Longitudinal Community-Based Study Open
Objective: To investigate baseline factors associated with caregiver-reported wandering among community-dwelling veterans with mild dementia. Methods: Veterans with mild dementia (N = 143) and their caregivers participated in a 2-year pros…
Impact of programs to reduce antipsychotic and anticholinergic use in nursing homes Open
Introduction Antipsychotics are used for managing behavioral and psychological symptoms of dementia (BPSD) but have risks. Anticholinergics can worsen outcomes in dementia. The Improving Antipsychotic Appropriateness in Dementia Patients e…
Prediction of Relapse After Discontinuation of Antipsychotic Treatment in Alzheimer’s Disease: The Role of Hallucinations Open
Patients with severe baseline hallucinations were more likely to relapse after randomization, and the presence of baseline hallucinations was associated with a higher risk of relapse after discontinuation of risperidone compared with conti…
Structure of the Psychotic Disorders Classification in DSM-5 Open
(Reprinted with permission from Schizophrenia Research 2013; 150:11-14).