Susan M. Smith
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View article: New ways of working in Irish general practice: Policy implications for medical workforce planning
New ways of working in Irish general practice: Policy implications for medical workforce planning Open
View article: Understanding changes in complex care needs over time: key research insights into multimorbidity trajectories
Understanding changes in complex care needs over time: key research insights into multimorbidity trajectories Open
Multimorbidity, the coexistence of multiple chronic diseases or conditions, poses a major challenge for health-care systems worldwide. Traditional research has largely relied on cross-sectional studies, offering limited insight into multim…
View article: Multilingual voice-enabled informatics tools: Catalyst for equitable AI in HIV and HIV-comorbidity healthcare management
Multilingual voice-enabled informatics tools: Catalyst for equitable AI in HIV and HIV-comorbidity healthcare management Open
Human Immunodeficiency Virus (henceforth HIV) is a global health problem, presently with no known cure. Africa has one of the highest incidences of HIV. Nigeria, within the West African (WA) region, is one of the largest economies on the c…
View article: Developing an approach for assigning GRADE levels in a systematic overview of reviews of diagnostic test accuracy using general principles identified from current GRADE guidelines: A case study
Developing an approach for assigning GRADE levels in a systematic overview of reviews of diagnostic test accuracy using general principles identified from current GRADE guidelines: A case study Open
Existing guidelines on overviews of reviews and umbrella reviews recommend an assessment of the certainty of evidence, but provide limited guidance on ‘how to’ apply the Grading of Recommendations Assessment, Development, and Evaluation (G…
View article: Associations between Multimorbidity Clusters and All-Cause Mortality, Quality of Life and Physical Function: A Systematic Review Protocol
Associations between Multimorbidity Clusters and All-Cause Mortality, Quality of Life and Physical Function: A Systematic Review Protocol Open
Background Multimorbidity, defined as the coexistence of two or more chronic health conditions in affected individuals, is recognised as a significant global public health concern.. While previous research has identified common multimorbid…
View article: Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study
Personalised exercise-rehabilitation for people with multiple long-term conditions (PERFORM): a randomised feasibility study Open
Objective Existing exercise-based rehabilitation services, such as cardiac and pulmonary rehabilitation, are traditionally commissioned around single long-term conditions (LTCs) and therefore may not meet the complex needs of adults with m…
View article: Personalised Exercise Rehabilitation FOR people with Multiple long-term conditions (PERFORM): findings from a process evaluation of a randomised feasibility study
Personalised Exercise Rehabilitation FOR people with Multiple long-term conditions (PERFORM): findings from a process evaluation of a randomised feasibility study Open
Objective The number of people living with multiple long-term conditions (MLTCs or ‘multimorbidity’) is growing. Evidence indicates that exercise-based rehabilitation can improve health-related quality of life and reduce hospital admission…
View article: Co-design and development of a Personalised Exercise-based Rehabilitation and self-management programme FOR people with Multiple long-term conditions: The PERFORM intervention
Co-design and development of a Personalised Exercise-based Rehabilitation and self-management programme FOR people with Multiple long-term conditions: The PERFORM intervention Open
Background Exercise and self-management support may be clinically effective and cost-effective treatments for a range of individual long-term conditions (LTCs), as they activate multiple beneficial physiological and psychological mechanism…
View article: Medicines support and socIal prescribing to aDdress pAtient prioritieS in multimorbidity (MIDAS): A process evaluation protocol
Medicines support and socIal prescribing to aDdress pAtient prioritieS in multimorbidity (MIDAS): A process evaluation protocol Open
Introduction Multimorbidity, living with ≥ two chronic conditions, is associated with adverse health outcomes and increased health service use. The ‘Medicines support and socIal prescribing to aDdress pAtient prioritieS in multimorbidity’ …
View article: Six provocations on the origins and impacts of the UK housing emergency
Six provocations on the origins and impacts of the UK housing emergency Open
British housing systems seem trapped in a ‘perfect storm’ of rising costs, declining choice, affordability stress, and unmet need. Housing outcomes are increasingly polarised, with implications for intergenerational conflict, economic and …
View article: Impact of eliciting treatment priorities on analgesic prescribing in older patients with high levels of polypharmacy
Impact of eliciting treatment priorities on analgesic prescribing in older patients with high levels of polypharmacy Open
Background Multimorbidity guidelines recommend tailoring care to patients’ priorities. The Supporting Prescribing in Multimorbidity in Primary Care (SPPiRE) trial focused on optimizing medicines use in older adults with significant polypha…
View article: 127 | HEALTH‐RELATED QUALITY OF LIFE (HRQoL) ENDPOINTS OF THE PHASE III INTERGROUP S1826 ADVANCED‐STAGE, CLASSIC HODGKIN LYMPHOMA (cHL) TRIAL
127 | HEALTH‐RELATED QUALITY OF LIFE (HRQoL) ENDPOINTS OF THE PHASE III INTERGROUP S1826 ADVANCED‐STAGE, CLASSIC HODGKIN LYMPHOMA (cHL) TRIAL Open
View article: 233 | S1608: RANDOMIZED PHASE II TRIAL COMPARING LENALIDOMIDE/OBINUTUZUMAB AND UMBRALISIB/OBINUTUZUMAB WITH CHEMOIMMUNOTHERAPY IN EARLY PROGRESSING FOLLICULAR LYMPHOMA (POD24)
233 | S1608: RANDOMIZED PHASE II TRIAL COMPARING LENALIDOMIDE/OBINUTUZUMAB AND UMBRALISIB/OBINUTUZUMAB WITH CHEMOIMMUNOTHERAPY IN EARLY PROGRESSING FOLLICULAR LYMPHOMA (POD24) Open
View article: 20 | IMPACT OF EBV STATUS AND HISTOLOGY ON OUTCOMES WITH NIVOLUMAB‐AVD VERSUS Bv‐AVD IN PATIENTS ENROLLED ON SWOG S1826
20 | IMPACT OF EBV STATUS AND HISTOLOGY ON OUTCOMES WITH NIVOLUMAB‐AVD VERSUS Bv‐AVD IN PATIENTS ENROLLED ON SWOG S1826 Open
View article: 21 | PROGNOSTIC VALUE OF CIRCULATING TUMOR DNA IN PATIENTS WITH ADVANCED STAGE CLASSIC HODGKIN LYMPHOMA TREATED ON SWOG S1826
21 | PROGNOSTIC VALUE OF CIRCULATING TUMOR DNA IN PATIENTS WITH ADVANCED STAGE CLASSIC HODGKIN LYMPHOMA TREATED ON SWOG S1826 Open
View article: Study protocol and data dictionary: Effectiveness of a GP delivered medication review in reducing polypharmacy and potentially inappropriate prescribing in older patients with multimorbidity in Irish primary care: a cluster randomised controlled trial (SPPiRE study)
Study protocol and data dictionary: Effectiveness of a GP delivered medication review in reducing polypharmacy and potentially inappropriate prescribing in older patients with multimorbidity in Irish primary care: a cluster randomised controlled trial (SPPiRE study) Open
Methods Study design and participants The methods for the SPPiRE cluster RCT have been described in the trial protocol (21). This study is reported in line with the CONSORT 2010 cluster RCT checklist (22), see Appendix 1, and was approved …
View article: The association between multimorbidity and out-of-pocket expenditure for prescription medicines among adults in Denmark: A population-based register study
The association between multimorbidity and out-of-pocket expenditure for prescription medicines among adults in Denmark: A population-based register study Open
For adults in Denmark, multimorbidity was associated with significantly higher out-of-pocket prescription medicine expenditure, even after controlling for demographic and socioeconomic covariates. This is similar to patterns in other count…
View article: Prevalence and risk factors of frailty in people experiencing homelessness: A systematic review and meta-analysis
Prevalence and risk factors of frailty in people experiencing homelessness: A systematic review and meta-analysis Open
This study highlights a high prevalence of frailty and pre-frailty in PEH. The identified risk factors illustrate potential areas to target interventions to reverse frailty. Future research should focus on the role of screening for frailty…
View article: Prof Martin Fortin, An appreciation
Prof Martin Fortin, An appreciation Open
View article: Family-based interventions for adults with type 2 diabetes mellitus: A systematic review and meta-analysis
Family-based interventions for adults with type 2 diabetes mellitus: A systematic review and meta-analysis Open
Family-based interventions involve family members in caring for patients with diabetes, but it is unclear whether they are effective in improving outcomes for type 2 diabetes (T2DM). This systematic review and meta-analysis aim to determin…
View article: Barriers and enablers to the management of osteoarthritis in primary care in Ireland from the perspective of healthcare professionals and individuals with osteoarthritis: a qualitative study using the Theoretical Domains Framework
Barriers and enablers to the management of osteoarthritis in primary care in Ireland from the perspective of healthcare professionals and individuals with osteoarthritis: a qualitative study using the Theoretical Domains Framework Open
Objectives To explore the barriers and enablers to providing and receiving primary care for osteoarthritis (OA) in Ireland from the perspectives of primary care healthcare professionals (HCPs) and individuals with OA. Design Descriptive qu…
View article: PD36 Assigning GRADE Levels To An Overview Of Reviews Using General Principles Identified From Current GRADE Guidelines
PD36 Assigning GRADE Levels To An Overview Of Reviews Using General Principles Identified From Current GRADE Guidelines Open
Introduction Existing guidelines on overviews of reviews and umbrella reviews recommend an assessment of the certainty of evidence but provide limited guidance on how to apply GRADE to such a complex evidence synthesis. We present one appr…
View article: Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis
Alcohol induces p53-mediated apoptosis in neural crest by stimulating an AMPK-mediated suppression of TORC1, S6K, and ribosomal biogenesis Open
Prenatal alcohol exposure is a leading cause of permanent neurodevelopmental disability and can feature distinctive craniofacial deficits that partly originate from the apoptotic deletion of craniofacial progenitors, a stem cell lineage ca…
View article: P081 With “standard” vaginoplasty technique, are surgeons positioning the neoclitoris in the same location in the vulva as in a cisgender woman? Results of anatomic and MRIbased studies and, a novel surgical technique for orthotopic placement
P081 With “standard” vaginoplasty technique, are surgeons positioning the neoclitoris in the same location in the vulva as in a cisgender woman? Results of anatomic and MRIbased studies and, a novel surgical technique for orthotopic placement Open
View article: V23 A novel surgical technique to eliminate penile erections in transgender women - bilateral crural dissection, incision and cavernosal artery and crural ligation
V23 A novel surgical technique to eliminate penile erections in transgender women - bilateral crural dissection, incision and cavernosal artery and crural ligation Open
View article: P052 How much of the genital area can people actually see directly with their own eyes? An assessment of genital visual fields important for cisgender and transgender people
P052 How much of the genital area can people actually see directly with their own eyes? An assessment of genital visual fields important for cisgender and transgender people Open
View article: P078 A proposed surgical technique to create a natural-appearing recessed vaginal introitus with gender-affirming shallow-depth vaginoplasty (vulvoplasty) utilizing a pedicled advancement flap
P078 A proposed surgical technique to create a natural-appearing recessed vaginal introitus with gender-affirming shallow-depth vaginoplasty (vulvoplasty) utilizing a pedicled advancement flap Open
View article: Implementation of Assessment Software to Evaluate First-Year Health Science Students’ Interprofessional Event Reflections
Implementation of Assessment Software to Evaluate First-Year Health Science Students’ Interprofessional Event Reflections Open
View article: Recommendations for managing adults with chronic non‐cancer pain in primary care: A systematic clinical guideline review
Recommendations for managing adults with chronic non‐cancer pain in primary care: A systematic clinical guideline review Open
Rationale Chronic non‐cancer pain (CNCP) is a leading driver of disability. Primary care clinicians treat most patients with CNCP. Yet, they are often unable to identify appropriate pain treatments, mainly due to concerns about the safety …
View article: Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts
Association of latent class analysis-derived multimorbidity clusters with adverse health outcomes in patients with multiple long-term conditions: comparative results across three UK cohorts Open