Explanipedia

Serum zinc level independently predicts need for inpatient intubation among patients hospitalized with COVID‐19: A prospective observational study Open

Scott W. McPherson, Frederik J. van Kuijk, Susan Vitale, Kathleen Mahan, David A. Wacker · 2025

Background The coronavirus disease 2019 (COVID‐19) pandemic caused significant morbidity and mortality. Further study of modifiable factors influencing COVID‐19 severity and outcomes continues to be necessary. Serum zinc levels may play a …

Changes in vision-related quality of life before and after geographic atrophy development in Age-Related Eye Disease Study participants Open

Minali Prasad, Susan Vitale, Emily Y. Chew · 2025

Single-cell spatial transcriptomic profiling defines a pathogenic inflammatory niche in chronic active multiple sclerosis lesions Open

Ruoqing Feng, Lena Spieth, Lu Liu, Stefan A. Berghoff, Jonas Franz , et al. · 2025

Compartmentalized inflammation is a key driver of multiple sclerosis (MS) progression, but the mechanisms sustaining its persistence remain unclear. A hallmark of this persistent and slowly evolving inflammatory process is chronic active M…

TFOS DEWS III: Digest Open

Fiona Stapleton, Pablo Argüeso, Penny A. Asbell, Dimitri T. Azar, Charles Bosworth , et al. · 2025

This digest summarizes the interdisciplinary research in dry eye disease (DED) published since the 2017 TFOS DEWS II reports. It comprises 7 topics including Sex, Gender, and Hormones; Epidemiology; Pathophysiology; Tear Film; Pain and Sen…

Prevalence and risk factors for the development of chronic postoperative pain after cataract surgery in the Age-related Eye Disease Study (AREDS) Open

Rony R. Sayegh, Susan Vitale, Elvira Agrón, John T. Farrar, Penny A. Asbell , et al. · 2025

Chronic ocular pain impacts quality of life and is often linked to ocular surgery. We assessed the prevalence of chronic postoperative pain (CPOP) after cataract surgery and associated risk factors using a secondary cohort post-hoc analysi…

Apolipoprotein E aggregation in microglia initiates Alzheimer’s disease pathology by seeding β-amyloidosis Open

Seiji Kaji, Stefan A. Berghoff, Lena Spieth, Lennart Schlaphoff, Andrew Octavian Sasmita , et al. · 2024

The seeded growth of pathogenic protein aggregates underlies the pathogenesis of Alzheimer's disease (AD), but how this pathological cascade is initiated is not fully understood. Sporadic AD is linked genetically to apolipoprotein E (APOE)…

Systemic Treatment with the Janus Kinase Inhibitor Baricitinib in Ocular Chronic Graft-versus-Host Disease Open

Taylor McManus, Noa G. Holtzman, Aaron T Zhao, Chantal Cousineau-Krieger, Susan Vitale , et al. · 2024

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Characterization of Retinal Microvascular Abnormalities in Birdshot Chorioretinopathy Using OCT Angiography Open

Aman Kumar, Alexander Zeleny, Sunil Bellur, Natasha Kesav, Enny Oyeniran , et al. · 2024

Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Ultrawide-field fluorescein angiography features in patients with anterior uveitis Open

Nam V. Nguyen, Enny Oyeniran, Alexander Zeleny, Michelle A. Chen, Noha Sherif , et al. · 2024

Purpose To evaluate the utility of ultrawide-field fluorescein angiography (UWFFA) in patients with anterior uveitis by investigating the detection of retinal vascular leakage (RVL) and the subsequent implications on disease diagnosis and …

Ultrawide-Field Fluorescein Angiography Features in Patients with Anterior Uveitis Open

Shilpa Kodati, Nam V. Nguyen, Enny Oyeniran, Alexander Zeleny, Michelle A. Chen , et al. · 2023

Purpose: To evaluate the utility of ultrawide-field fluorescein angiography (UWFFA) in patients with anterior uveitis by investigating the detection of retinal vascular leakage (RVL) and the subsequent implications on disease diagnosis and…

Antidrug Antibodies to Tumor Necrosis Factor α Inhibitors in Patients With Noninfectious Uveitis Open

Sunil Bellur, Matthew McHarg, Wijak Kongwattananon, Susan Vitale, H. Nida Sen , et al. · 2022

Importance Tumor necrosis factor inhibitors (TNFis) can induce antidrug antibody (ADA) formation and loss of therapeutic response. However, the utility of ADA testing and the association between ADAs and treatment response in patients with…

Refractive Surgery Preferred Practice Pattern® Open

Deborah S. Jacobs, Jimmy K. Lee, Tueng T. Shen, Natalie A. Afshari, Rachel Bishop , et al. · 2022

Refractive Errors Preferred Practice Pattern® Open

Deborah S. Jacobs, Natalie A. Afshari, Rachel Bishop, Jeremy D. Keenan, Jimmy H. M. Lee , et al. · 2022

Ocular Findings of Cryptococcal Meningitis in Previously Healthy Adults Open

Chinwenwa Okeagu, Seher Anjum, Susan Vitale, Jing Wang, Deven Singh , et al. · 2022

Background: Patients with cryptococcal meningitis (CM) often have ocular manifestations; although data are describing these findings in nonimmunosuppressed, previously healthy individuals are scarce. Methods: A retrospective chart review w…

Novel ophthalmic findings and deep phenotyping in Williams-Beuren syndrome Open

Laryssa A. Huryn, Taylor Flaherty, Rosalie Nolen, Lev Prasov, Wadih M. Zein , et al. · 2022

Background/Aims To characterise the ocular manifestations of Williams-Beuren syndrome (WBS) and compare these to patients with isolated elastin mediated supravalvular aortic stenosis (SVAS). Methods Fifty-seven patients with a diagnosis of…

Long-term Outcomes of Adding Lutein/Zeaxanthin and ω-3 Fatty Acids to the AREDS Supplements on Age-Related Macular Degeneration Progression Open

Emily Y. Chew, Traci E. Clemons, Elvira Agrón, Amitha Domalpally, Tiarnán D L Keenan , et al. · 2022

Results of this long-term epidemiologic follow-up study of the AREDS2 cohort suggest that lutein/zeaxanthin was an appropriate replacement for beta carotene in AREDS2 supplements. Beta carotene usage nearly doubled the risk of lung cancer,…

Contents Open

S. Bhandari, Susan Vitale, Elvira Agrón, Traci E. Clemons, Annemijn P. A. Wierenga , et al. · 2022

Comparison of Optical Coherence Tomography Angiography and Indocyanine Green Angiography in Uveitis Open

Shilpa Kodati, Aman Kumar, Wijak Kongwattananon, Susan Vitale, H. Nida Sen · 2022

Optical Coherence Tomography Angiography (OCTA) has emerged as a useful modality for the diagnosis and management of uveitic diseases, but comparisons with other imaging modalities in uveitis are limited. The purpose of this study is to co…

Editorial Board Open

Clarence Loeb, Arthur Proetz, William Wherry, William L. Benedict, William H. Morrison , et al. · 2021

Cataract Surgery and the Risk of Developing Late Age-Related Macular Degeneration Open

S. Bhandari, Susan Vitale, Elvira Agrón, Traci E. Clemons, Emily Y. Chew · 2021

Editorial Board Open

Clarence Loeb, Arthur Proetz, William Wherry, William L. Benedict, William H. Morrison , et al. · 2021

Cataract Surgery and the Risk of Progression to Late Age-Related Macular Degeneration: The Age-Related Eye Disease Study 2 Open

S. Bhandari, Elvira Agrón, Susan Vitale, David Peprah, Maureen Farrell , et al. · 2021

Does cataract surgery increase the risk of future development of late AMD? A nested case-control study from the AREDS2 and AREDS2 Follow-On studies Open

Susan Vitale, Elvira Agrón, S. Bhandari, David Peprah, Maureen Farrell , et al. · 2021

Principal Cause of Poor Visual Acuity after Neovascular Age-Related Macular Degeneration Open

Chinwenwa Okeagu, Elvira Agrón, Susan Vitale, Amitha Domalpally, Emily Y. Chew , et al. · 2020

Utility of Optical Coherence Tomography in the Diagnosis and Management of Optic Neuropathy in Patients with Fibrous Dysplasia Open

Kristen S. Pan, Edmond J. FitzGibbon, Susan Vitale, Janice S. Lee, Michael T. Collins , et al. · 2020

Optic neuropathy (ON) is a highly disabling complication of fibrous dysplasia (FD). The optimal test for identifying and monitoring ON in FD is unknown. Optical coherence tomography (OCT) is an imaging modality that detects retinal nerve f…

Hierarchical Cluster Analysis of Serum and Vitreous Cytokines in Intermediate, Posterior and Panuveitis Open

David Dao, Sonny Caplash, Sapna Gangaputra, Pradeep K. Dagur, Susan Vitale , et al. · 2020

Association of 2-Year Progression Along the AREDS AMD Scale and Development of Late Age-Related Macular Degeneration or Loss of Visual Acuity Open

Susan Vitale, Elvira Agrón, Traci E. Clemons, Tiarnán D L Keenan, Amitha Domalpally , et al. · 2020

Two-year progression of AMD score was associated with progression to clinically meaningful anatomic (late AMD) and vision (≥2-line or ≥3-line loss) outcomes, suggesting that this scale may be useful for future clinical trials designed to s…

Editorial Board Open

Stephen D. McLeod, San Francisco, Daniel Albert, George B. Bartley, Creig Hoyt , et al. · 2020

Reproducibility of Full-field Electroretinogram Measurements in Birdshot Chorioretinopathy Patients: An Intra- and Inter-visit Analysis Open

Jared E. Knickelbein, Brett G. Jeffrey, Maggie M. Wei, Shuk Kei Cheng, Natasha Kesav , et al. · 2020

Purpose: Aims to determine the variability of ffERG measurements in patients with clinically stable birdshot chorioretinopathy (BCR).Methods: Repeatability coefficients (RC) of ffERG amplitudes and implicit times were calcula…

Editorial Board Open

Stephen D. McLeod, San Francisco, Daniel Albert, George B. Bartley, Creig Hoyt , et al. · 2019

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