H. Susan Zhou
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View article: Independent Tuning of Stiffness and Pore Size in 3D Rat Tail Collagen I Matrices
Independent Tuning of Stiffness and Pore Size in 3D Rat Tail Collagen I Matrices Open
The interplay between the extracellular matrix (ECM) mechanical properties and the tumor microenvironment is increasingly recognized as a critical factor in cancer progression. Three-dimensional (3D) culture systems have emerged as essenti…
View article: Identification and Characterization of bZIP Gene Family Combined Transcriptome Analysis Revealed Their Functional Roles on Abiotic Stress and Anthocyanin Biosynthesis in Mulberry (Morus alba)
Identification and Characterization of bZIP Gene Family Combined Transcriptome Analysis Revealed Their Functional Roles on Abiotic Stress and Anthocyanin Biosynthesis in Mulberry (Morus alba) Open
The basic leucine zipper (bZIP) gene family constitutes one of the most abundant and conserved transcription factor families in plants, which participates in diverse physiological processes including response to abiotic stress, anthocyanin…
View article: Investigation of Cell Mechanics and Migration on DDR2-Expressing Neuroblastoma Cell Line
Investigation of Cell Mechanics and Migration on DDR2-Expressing Neuroblastoma Cell Line Open
Neuroblastoma is a devastating disease accounting for ~15% of all childhood cancer deaths. Collagen content and fiber association within the tumor stroma influence tumor progression and metastasis. High expression levels of collagen recept…
View article: Investigation of cell mechanics and migration on DDR2-expressing neuroblastoma cell line
Investigation of cell mechanics and migration on DDR2-expressing neuroblastoma cell line Open
Neuroblastoma is a devastating disease accounting for ~15% of all childhood cancer deaths. Collagen content and fiber association within the tumor stroma influence tumor progression and metastasis. High expression levels of collagen recept…
View article: Intelligent and ligand-based surface-enhanced Raman spectroscopy biosensors for the instant screening of viral respiratory infections
Intelligent and ligand-based surface-enhanced Raman spectroscopy biosensors for the instant screening of viral respiratory infections Open
The global spread of viral respiratory infections continues to pose a substantial threat to human health, exacerbating the societal burden. Timely and precise detection of viruses is pivotal in mitigating pandemic transmission. Currently, …
View article: Data from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Data from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Oncogene-driven expression and activation of receptor tyrosine kinases promotes tumorigenesis and contributes to drug resistance. Increased expression of the kinases discoidin domain receptor 2 (DDR2), RET Proto-Oncogene (RET), Platelet De…
View article: Supplemental Figure 2 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 2 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Tetracycline-inducible DDR2 downregulation confirms the critical role of DDR2 as the central mediator of collagen signaling in neuroblastoma cells.
View article: Supplemental Figure 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Chemical structure of sitravatinib
View article: Supplemental Figure 9 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 9 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Single cell RNA sequencing of neuroblastoma patient samples demonstrates intra and inter tumor heterogeneity of SCP-like cells.
View article: Supplemental Figure 10 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 10 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Sitravatinib + Lorlatinib combination in neuroblastoma cell proliferation.
View article: Supplemental Figure 4 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 4 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Relative weight (%) along time (age) of mice from Kelly orthotopic tumor model from Figure 2D-F).
View article: Data from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Data from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Oncogene-driven expression and activation of receptor tyrosine kinases promotes tumorigenesis and contributes to drug resistance. Increased expression of the kinases discoidin domain receptor 2 (DDR2), RET Proto-Oncogene (RET), Platelet De…
View article: Supplemental Figure 7 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 7 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Expression of DDR2 transcriptional targets PCOLCE and MAGED4B is highly enriched in Neuroblastoma cell lines.
View article: Supplemental Figure 2 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 2 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Tetracycline-inducible DDR2 downregulation confirms the critical role of DDR2 as the central mediator of collagen signaling in neuroblastoma cells.
View article: Supplemental Figure 8 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 8 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
DDR1 and DDR2 in cancer cell lines.
View article: Supplemental Figure 4 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 4 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Relative weight (%) along time (age) of mice from Kelly orthotopic tumor model from Figure 2D-F).
View article: Supplemental Figure 3 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 3 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Sitravatinib inhibits proliferation of neuroblastoma cell lines.
View article: Supplemental Figure 8 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 8 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
DDR1 and DDR2 in cancer cell lines.
View article: Supplemental Table 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Table 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Oligonucleotide primer sequences and shRNA clones used in this work.
View article: Supplemental Figure 6 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 6 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Overexpression of DDR2 in 293 T cells renders these cells less sensitive to Sitravatinib inhibition of DDR2 signaling.
View article: Supplemental Figure 9 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 9 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Single cell RNA sequencing of neuroblastoma patient samples demonstrates intra and inter tumor heterogeneity of SCP-like cells.
View article: Supplemental Figure 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Chemical structure of sitravatinib
View article: Supplemental Figure 5 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 5 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Relative weight (%) along time (age) of mice from Th-MYCN tumor model from Figure 3).
View article: Supplemental Figure 3 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 3 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Sitravatinib inhibits proliferation of neuroblastoma cell lines.
View article: Supplemental Figure 10 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 10 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Sitravatinib + Lorlatinib combination in neuroblastoma cell proliferation.
View article: Supplemental Figure 6 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 6 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Overexpression of DDR2 in 293 T cells renders these cells less sensitive to Sitravatinib inhibition of DDR2 signaling.
View article: Supplemental Table 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Table 1 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Oligonucleotide primer sequences and shRNA clones used in this work.
View article: Supplemental Figure 5 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis
Supplemental Figure 5 from Blockade of Discoidin Domain Receptor Signaling with Sitravatinib Reveals DDR2 as a Mediator of Neuroblastoma Pathogenesis and Metastasis Open
Relative weight (%) along time (age) of mice from Th-MYCN tumor model from Figure 3).