Susana Amézqueta
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View article: Fecal Short-Chain Fatty Acids to Predict Prediabetes and Type 2 Diabetes Risk: An Exploratory Cross-Sectional Study
Fecal Short-Chain Fatty Acids to Predict Prediabetes and Type 2 Diabetes Risk: An Exploratory Cross-Sectional Study Open
Background/Objectives: Gut microbiota is profoundly influenced by dysglycemic states, including prediabetes (preDM) and type 2 diabetes (T2D). Although short-chain fatty acids (SCFAs) may serve as proxies reflecting these microbial changes…
View article: Dietary Consumption of Type 2 Resistant Starch and <scp>d</scp> ‐Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High‐Fat Diet
Dietary Consumption of Type 2 Resistant Starch and <span>d</span> ‐Fagomine Delays Progression of Metabolic Disturbances in Male Rats on High‐Fat Diet Open
High‐fat (HF) diets contribute to obesity, insulin resistance, fatty liver, gut microbiota dysbiosis, oxidative stress, and low‐grade chronic inflammation. This study evaluated the preventive effects of dietary Type 2 resistant starch (RS2…
View article: Towards biomimetic electrochromatography: Fast method for the Abraham’s characterization of solute-solvent interactions in micellar and microemulsion electrokinetic systems
Towards biomimetic electrochromatography: Fast method for the Abraham’s characterization of solute-solvent interactions in micellar and microemulsion electrokinetic systems Open
This study presents a fast method for the characterization of solute-solvent interactions in micellar and microemulsion electrokinetic chromatography based on the linear solvation energy relationships proposed by Abraham. The magnitude of …
View article: Characterization of biosurfactants’ micelles formation using fluorescence measurements: sodium taurocholate as case of study
Characterization of biosurfactants’ micelles formation using fluorescence measurements: sodium taurocholate as case of study Open
Background and purpose: The evaluation of micellization parameters of surfactants that aggregate gradually, such as bile salts, is not trivial. In this work, different probes and data treatment models are tested to set up an analytical met…
View article: Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet
Influence of Dietary Inulin on Fecal Microbiota, Cardiometabolic Risk Factors, Eicosanoids, and Oxidative Stress in Rats Fed a High-Fat Diet Open
The present study examined the influence of inulin on fecal microbiota, cardiometabolic risk factors, eicosanoids, and oxidative stress in rats on a high-fat (HF) diet. Thirty-six male Wistar–Kyoto rats were divided into three dietary grou…
View article: Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats
Fiber-like Action of d-Fagomine on the Gut Microbiota and Body Weight of Healthy Rats Open
The goal of this work is to explore if the changes induced by d-fagomine in the gut microbiota are compatible with its effect on body weight and inflammation markers in rats. Methods: Sprague Dawley rats were fed a standard diet supplement…
View article: Insights into the Responding Modes of Highly Potent Gadolinium-Based Magnetic Resonance Imaging Probes Sensitive to Zinc Ions
Insights into the Responding Modes of Highly Potent Gadolinium-Based Magnetic Resonance Imaging Probes Sensitive to Zinc Ions Open
Zn ions (Zn2+) play an important biological role in many diseases; hence, an imaging method for monitoring the Zn2+ distribution in tissues could provide important clinical insights. Recently, we reported a potent Zn-sensitive probe based …
View article: Evaluation of the Interactions between Human Serum Albumin (HSA) and Non-Steroidal Anti-Inflammatory (NSAIDs) Drugs by Multiwavelength Molecular Fluorescence, Structural and Computational Analysis
Evaluation of the Interactions between Human Serum Albumin (HSA) and Non-Steroidal Anti-Inflammatory (NSAIDs) Drugs by Multiwavelength Molecular Fluorescence, Structural and Computational Analysis Open
The interaction between drugs and transport proteins, such as albumins, is a key factor in drug bioavailability. One of the techniques commonly used for the evaluation of the drug-protein complex formation is fluorescence. This work studie…
View article: Inter‐Individual Variability in Insulin Response after Grape Pomace Supplementation in Subjects at High Cardiometabolic Risk: Role of Microbiota and miRNA
Inter‐Individual Variability in Insulin Response after Grape Pomace Supplementation in Subjects at High Cardiometabolic Risk: Role of Microbiota and miRNA Open
Scope Dietary polyphenols have shown promising effects in mechanistic and preclinical studies on the regulation of cardiometabolic alterations. Nevertheless, clinical trials have provided contradictory results, with high inter‐individual v…
View article: Implication of gut microbiota in the physiology of rats intermittently exposed to cold and hypobaric hypoxia
Implication of gut microbiota in the physiology of rats intermittently exposed to cold and hypobaric hypoxia Open
This study examines the influence of intermittent exposure to cold, hypobaric hypoxia, and their combination, in gut microbiota and their metabolites in vivo, and explores their effects on the physiology of the host. Sprague-Dawley rats we…
View article: Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial
Modifications of Gut Microbiota after Grape Pomace Supplementation in Subjects at Cardiometabolic Risk: A Randomized Cross-Over Controlled Clinical Trial Open
Polyphenols are dietary bioactive compounds able to induce modifications in the gut microbiota profile, although more clinical studies are needed. With this aim, a randomized cross-over clinical trial was conducted, where 49 subjects at ca…
View article: Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system
Estimation of the octanol-water distribution coefficient of basic compounds by a cationic microemulsion electrokinetic chromatography system Open
The octanol-water partition coefficient (Po/w), or the octanol-water distribution coefficient (Do/w) for ionized compounds, is a key parameter in the drug development process. In a previous work, this parameter was estimated through the re…
View article: The buckwheat iminosugar D-fagomine attenuates sucrose-induced steatosis and hypertension in rats
The buckwheat iminosugar D-fagomine attenuates sucrose-induced steatosis and hypertension in rats Open
D-Fagomine (1,2 dideoxynojirimycin) is an iminosugar, a carbohydrate analogue that includes an endocyclic nitrogen instead of oxygen, that is naturally present in buckwheat and buckwheat-based foodstuffs. This study examines the long-term …
View article: Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet
Effects of combined d-fagomine and omega-3 PUFAs on gut microbiota subpopulations and diabetes risk factors in rats fed a high-fat diet Open
Food contains bioactive compounds that may prevent changes in gut microbiota associated with Westernized diets. The aim of this study is to explore the possible additive effects of d -fagomine and ω-3 PUFAs (EPA/DHA 1:1) on gut microbiota …
View article: Combined Buckwheat d-Fagomine and Fish Omega-3 PUFAs Stabilize the Populations of Gut Prevotella and Bacteroides While Reducing Weight Gain in Rats
Combined Buckwheat d-Fagomine and Fish Omega-3 PUFAs Stabilize the Populations of Gut Prevotella and Bacteroides While Reducing Weight Gain in Rats Open
Some functional food components may help maintain homeostasis by promoting balanced gut microbiota. Here, we explore the possible complementary effects of d-fagomine and ω-3 polyunsaturated fatty acids (ω-3 PUFAs) eicosapentaenoic acid/doc…
View article: The Buckwheat Iminosugar <scp>d</scp>‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats
The Buckwheat Iminosugar <span>d</span>‐Fagomine Attenuates Sucrose‐Induced Steatosis and Hypertension in Rats Open
Scope This study examines the long‐term functional effects of d ‐fagomine on sucrose‐induced factors of metabolic dysfunctions and explores possible molecular mechanisms behind its action. Methods and results Wistar Kyoto rats are fed a 35…
View article: The influence of combined buckwheat D-fagomine and fish omega-3 PUFAs on beneficial gut bacteria in rats
The influence of combined buckwheat D-fagomine and fish omega-3 PUFAs on beneficial gut bacteria in rats Open
Poster.-- 13th European Nutrition Conference - Malnutrition in an Obese World: European Perspectives, Dublin, 15-18 October 2019
View article: Front cover: Functional Effects of the Buckwheat Iminosugar <scp>d</scp>‐Fagomine on Rats with Diet‐Induced Prediabetes
Front cover: Functional Effects of the Buckwheat Iminosugar <span>d</span>‐Fagomine on Rats with Diet‐Induced Prediabetes Open
Mol. Nutr. Food Res. 2018, 62, 1800373 DOI: 10.1002/mnfr.201800373 d-Fagomine, an iminosugar found in buckwheat, counteracts the weight gain and elevated blood glucose levels induced by an excessive intake of fat. In article number 1800373…
View article: Functional Effects of the Buckwheat Iminosugar <scp>d</scp>‐Fagomine on Rats with Diet‐Induced Prediabetes
Functional Effects of the Buckwheat Iminosugar <span>d</span>‐Fagomine on Rats with Diet‐Induced Prediabetes Open
Scope The goals of this work are to test if d ‐fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat‐induced prediabetic state in a rat model and to explore possible mechanisms behind its functional actio…
View article: Feasibility of the estimation of octanol-water distribution coefficients of acidic drugs by microemulsion electrokinetic chromatography
Feasibility of the estimation of octanol-water distribution coefficients of acidic drugs by microemulsion electrokinetic chromatography Open
Previous studies have shown that a microemulsion electrokinetic chromatography (MEEKC) system can estimate the logarithm of the octanol-water partition coefficient (log Po/w) of neutral solutes. In the present work, the applicability of th…
View article: Evaluation of the interactions between human serum albumin (HSA) and warfarin or diflunisal by using molecular fluorescence using two approaches
Evaluation of the interactions between human serum albumin (HSA) and warfarin or diflunisal by using molecular fluorescence using two approaches Open
Serum albumin is the main drug transporter of the bloodstream and contains two main binding sites: Sudlow I or acidic drug binding site, and Sudlow II or benzodiazepine binding site. Warfarin, a well-known anticoagulant drug commonly used …
View article: Mechanistically different effects of fat and sugar on insulin resistance, hypertension, and gut microbiota in rats
Mechanistically different effects of fat and sugar on insulin resistance, hypertension, and gut microbiota in rats Open
Insulin resistance (IR) and impaired glucose tolerance (IGT) are the first manifestations of diet-induced metabolic alterations leading to Type 2 diabetes, while hypertension is the deadliest risk factor of cardiovascular disease. The role…
View article: Molecular interactions between warfarin and human (HSA) or bovine (BSA) serum albumin evaluated by isothermal titration calorimetry (ITC), fluorescence spectrometry (FS) and frontal analysis capillary electrophoresis (FA/CE)
Molecular interactions between warfarin and human (HSA) or bovine (BSA) serum albumin evaluated by isothermal titration calorimetry (ITC), fluorescence spectrometry (FS) and frontal analysis capillary electrophoresis (FA/CE) Open
Interaction thermodynamics between warfarin, a very popular anticoagulant, and Sudlow I binding site of human (HSA) or bovine (BSA) serum albumin have been examined in strictly controlled experimental conditions (HEPES buffer 50 mM, pH 7.4…