Susana Fernández
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View article: Manual and automated synthesis of modified oligonucleotides on core–shell solid supports
Manual and automated synthesis of modified oligonucleotides on core–shell solid supports Open
A critical step in the manufacturing of oligonucleotides is the selection of ideal solid supports. Herein, we evaluate a hybrid core–shell solid support made of polystyrene and polyethyleneglycol, for the preparation of oligonucleotides us…
View article: The synthesis of solid supports carrying base labile linkers to generate 3′-phosphate oligonucleotides
The synthesis of solid supports carrying base labile linkers to generate 3′-phosphate oligonucleotides Open
Oligonucleotides carrying 3'-terminal phosphates and conjugates are important tools in molecular biology and diagnostic purposes. We described the preparation of solid supports carrying the base labile linker 4-((2-hydroxyethyl)sulfonyl)be…
View article: Synthesis of 2′-<i>O</i>-Methyl/2′-<i>O</i>-MOE-L-Nucleoside Derivatives and Their Applications: Preparation of G-Quadruplexes, Their Characterization, and Stability Studies
Synthesis of 2′-<i>O</i>-Methyl/2′-<i>O</i>-MOE-L-Nucleoside Derivatives and Their Applications: Preparation of G-Quadruplexes, Their Characterization, and Stability Studies Open
Nucleosides and their analogues constitute an important family of molecules with potential antiviral and antiproliferative activity. The enantiomers of natural nucleosides, l-nucleoside derivatives, which have comparable biological activit…
View article: Convergent Approaches and Biological Activity of C1 and/or C3 Mono or Diamino Derivatives of 1α,25‐Dihydroxy‐19‐<i>nor</i>‐vitamin D<sub>3</sub>. Key Enzymatic Desymmetrization of A‐Ring Synthon Precursor
Convergent Approaches and Biological Activity of C1 and/or C3 Mono or Diamino Derivatives of 1α,25‐Dihydroxy‐19‐<i>nor</i>‐vitamin D<sub>3</sub>. Key Enzymatic Desymmetrization of A‐Ring Synthon Precursor Open
Three novel 19‐ nor ‐1α,25‐dihydroxyvitamin D 3 derivatives modified at C1 and/or C3 with an amino group were synthesized to study the influence of the substitution of one or both hydroxyl groups of A‐ring by amino groups on the affinity f…
View article: Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives
Sustainable Protocol for the Synthesis of 2′,3′-Dideoxynucleoside and 2′,3′-Didehydro-2′,3′-dideoxynucleoside Derivatives Open
An improved protocol for the transformation of ribonucleosides into 2′,3′-dideoxynucleoside and 2′,3′-didehydro-2′,3′-dideoxynucleoside derivatives, including the anti-HIV drugs stavudine (d4T), zalcitabine (ddC) and didanosine (ddI), was …
View article: Clear cell sarcoma mimicking a breast tumor in an elderly man: a rare case report and a literature review
Clear cell sarcoma mimicking a breast tumor in an elderly man: a rare case report and a literature review Open
Objective: Clear Cell Sarcoma (CCS) is a rare tumor of mesenchymal origin accounting for 1% of soft tissue sarcomas (STS)1. Often misdiagnosed as malignant melanoma2 (MM), it has only one curative treatment: radical surgery and an extensiv…
View article: Oligonucleotides Containing 1-Aminomethyl or 1-Mercaptomethyl-2-deoxy-<scp>d</scp>-ribofuranoses: Synthesis, Purification, Characterization, and Conjugation with Fluorophores and Lipids
Oligonucleotides Containing 1-Aminomethyl or 1-Mercaptomethyl-2-deoxy-<span>d</span>-ribofuranoses: Synthesis, Purification, Characterization, and Conjugation with Fluorophores and Lipids Open
Oligonucleotide conjugates are widely used as therapeutic drugs, gene analysis, and diagnostic tools. A critical step in the biologically relevant oligonucleotide conjugates is the design and synthesis of functional molecules that connect …
View article: Strategies for the Synthesis of 19-nor-Vitamin D Analogs
Strategies for the Synthesis of 19-nor-Vitamin D Analogs Open
1α,25-Dihydroxyvitamin D3 [1α,25-(OH)2-D3], the hormonally active form of vitamin D3, classically regulates bone formation, calcium, and phosphate homeostasis. In addition, this hormone also exerts non-classical effects in a wide variety o…
View article: CCDC 1980305: Experimental Crystal Structure Determination
CCDC 1980305: Experimental Crystal Structure Determination Open
View article: Novel 1′-homo-<i>N</i>-2′-deoxy-α-nucleosides: synthesis, characterization and biological activity
Novel 1′-homo-<i>N</i>-2′-deoxy-α-nucleosides: synthesis, characterization and biological activity Open
Novel 1′-homo-N-2′-deoxy-α-nucleosides and dimers.
View article: Enzymatic Desymmetrization of 19‐<i>nor</i>‐Vitamin D<sub>3</sub> A‐Ring Synthon Precursor: Synthesis, Structure Elucidation, and Biological Activity of 1α,25‐Dihydroxy‐3‐<i>epi</i>‐19‐<i>nor</i>‐vitamin D<sub>3</sub> and 1β,25‐Dihydroxy‐19‐<i>nor</i>‐vitamin D<sub>3</sub>
Enzymatic Desymmetrization of 19‐<i>nor</i>‐Vitamin D<sub>3</sub> A‐Ring Synthon Precursor: Synthesis, Structure Elucidation, and Biological Activity of 1α,25‐Dihydroxy‐3‐<i>epi</i>‐19‐<i>nor</i>‐vitamin D<sub>3</sub> and 1β,25‐Dihydroxy‐19‐<i>nor</i>‐vitamin D<sub>3</sub> Open
In a search for novel vitamin D derivatives of potential therapeutic value, structurally simple but synthetically challenging A‐ring epimers of the 19‐nor‐ Calcitriol [19‐ nor ‐1α,25‐(OH) 2 ‐D 3 ] at C1 and C3 were efficiently synthesized.…
View article: The impact of an extended nucleobase-2′-deoxyribose linker in the biophysical and biological properties of oligonucleotides
The impact of an extended nucleobase-2′-deoxyribose linker in the biophysical and biological properties of oligonucleotides Open
The introduction of a novel thymine derivative at the 3′-end of the sense strand generates more potent and selective siRNAs.
View article: Short and Efficient Chemoenzymatic Syntheses of non‐Natural (−)‐Muscarine and (+)‐<i>allo</i>‐Muscarine from Cyano‐Sugar Precursors Catalyzed by Immobilized <i>Burkholderia cepacia</i> Lipase
Short and Efficient Chemoenzymatic Syntheses of non‐Natural (−)‐Muscarine and (+)‐<i>allo</i>‐Muscarine from Cyano‐Sugar Precursors Catalyzed by Immobilized <i>Burkholderia cepacia</i> Lipase Open
Enantiopure (2 R )‐configured non‐natural (−)‐muscarine and (+)‐ allo ‐muscarine were efficiently synthesized by a chemoenzymatic approach from an easily accessible cyano‐sugar available on a large‐scale. The key enzymatic hydrolysis step …
View article: A‐Ring‐Modified 2‐Hydroxyethylidene Previtamin D<sub>3</sub> Analogues: Synthesis and Biological Evaluation
A‐Ring‐Modified 2‐Hydroxyethylidene Previtamin D<sub>3</sub> Analogues: Synthesis and Biological Evaluation Open
To investigate the biological profile of the previtamin form of vitamin D, we synthesized new analogues of 19‐ nor ‐1α,25‐dihydroxyprevitamin D 3 bearing a 2‐hydroxyethylidene moiety at the A‐ring. The target compounds were prepared by con…
View article: Preparation of ORMOSIL nanoparticles conjugated with vitamin D<sub>3</sub>analogues and their biological evaluation
Preparation of ORMOSIL nanoparticles conjugated with vitamin D<sub>3</sub>analogues and their biological evaluation Open
Dye-doped multifunctional organically modified silica (ORMOSIL) nanoparticles were prepared within surfactant stabilized microemulsions and conjugated with several vitamin D3derivatives.
View article: Process Development of Biocatalytic Regioselective 5′-<i>O</i>-Levulinylation of 2′-Deoxynucleosides
Process Development of Biocatalytic Regioselective 5′-<i>O</i>-Levulinylation of 2′-Deoxynucleosides Open
An enzymatic process was optimized for regioselective levulinylation of the 5′-hydroxyl group in 2′-deoxynucleosides. The results revealed that the nucleobase protecting group influenced the successful outcome of the enzymatic reaction. Th…