Susana Muñoz Maniega
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View article: Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures
Brain maps of general cognitive functioning: neuroimaging and neurobiological signatures Open
In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms of morphometry, are most strongly related to individual differences in domain-general cognitive functioning ( g )? and 2) what are the underly…
View article: Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals
Signature White Matter Hyperintensity Locations Associated With Vascular Risk Factors Derived From 15 653 Individuals Open
BACKGROUND: White matter hyperintensities (WMHs) of presumed vascular origin are common in the elderly and are associated with vascular risk factors. There is evidence that vascular risk factors, in particular hypertension, are associated …
View article: Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI
Measurement characteristics and genome-wide correlates of lifetime brain atrophy estimated from a single MRI Open
View article: Uncertainty quantification for White Matter Hyperintensity segmentation detects silent failures and improves automated Fazekas quantification
Uncertainty quantification for White Matter Hyperintensity segmentation detects silent failures and improves automated Fazekas quantification Open
White Matter Hyperintensities (WMH) are key neuroradiological markers of small vessel disease present in brain MRI. Assessment of WMH is important in research and clinics. However, WMH are challenging to segment due to their high variabili…
View article: AI-based deformable hippocampal mesh reflects hippocampal morphological characteristics in relation to cognition in healthy older adults
AI-based deformable hippocampal mesh reflects hippocampal morphological characteristics in relation to cognition in healthy older adults Open
Magnetic resonance imaging (MRI)-derived hippocampus measurements have been associated with different cognitive domains. The knowledge of hippocampal structural deformations as we age has contributed to our understanding of the overall agi…
View article: Longitudinal Cognitive Changes in Cerebral Small Vessel Disease
Longitudinal Cognitive Changes in Cerebral Small Vessel Disease Open
WMH regression was associated with preserved global cognition and improved executive function, compared with stable WMH, while WMH progression was associated with global cognitive decline. Cognitive benefits of WMH regression suggest that …
View article: Blood-based epigenome-wide association study and prediction of alcohol consumption
Blood-based epigenome-wide association study and prediction of alcohol consumption Open
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error through recall bias. Instead, molecular data such as blood-based DNA methylation (DNAm) cou…
View article: Clinical Relevance of ‘Cap’ and ‘Track’ Development after Recent Small Subcortical Infarct
Clinical Relevance of ‘Cap’ and ‘Track’ Development after Recent Small Subcortical Infarct Open
Objective After a recent small subcortical infarct (RSSI), some patients develop perilesional or remote hyperintensities (‘caps/tracks’) to the index infarct on T2/FLAIR MRI. However, their clinical relevance remains unclear. We investigat…
View article: Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles
Brain maps of general cognitive function and spatial correlations with neurobiological cortical profiles Open
In this paper, we attempt to answer two questions: 1) which regions of the human brain, in terms of morphometry, are most strongly related to individual differences in domain-general cognitive functioning ( g )? and 2) what are the underly…
View article: Uncertainty quantification for White Matter Hyperintensity segmentation detects silent failures and improves automated Fazekas quantification
Uncertainty quantification for White Matter Hyperintensity segmentation detects silent failures and improves automated Fazekas quantification Open
White Matter Hyperintensities (WMH) are key neuroradiological markers of small vessel disease present in brain MRI. Assessment of WMH is important in research and clinics. However, WMH are challenging to segment due to their high variabili…
View article: Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals
Cerebral white matter hyperintensity volumes: Normative age- and sex-specific values from 15 population-based cohorts comprising 14,876 individuals Open
View article: Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease
Cerebrovascular Function in Sporadic and Genetic Cerebral Small Vessel Disease Open
Objective Cerebral small vessel diseases (SVDs) are associated with cerebrovascular dysfunction, such as increased blood–brain barrier leakage (permeability surface area product), vascular pulsatility, and decreased cerebrovascular reactiv…
View article: Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates
Lifetime brain atrophy estimated from a single MRI: measurement characteristics and genome-wide correlates Open
A measure of lifetime brain atrophy (LBA) obtained from a single magnetic resonance imaging (MRI) scan could be an attractive candidate to boost statistical power in uncovering novel genetic signals and mechanisms of neurodegeneration. We …
View article: Prevalence and Clinical Implications of Hemosiderin Deposits in Recent Small Subcortical Infarcts
Prevalence and Clinical Implications of Hemosiderin Deposits in Recent Small Subcortical Infarcts Open
HDs occur commonly in RSSIs and may be associated with infarct volume and SVD score. Hemosiderin "rim" is common in RSSIs, urging caution to avoid mistaking ischemic RSSI for primary hemorrhage in subacute and chronic stages.
View article: Definitions of white matter hyperintensity change: impact on estimates of progression and regression
Definitions of white matter hyperintensity change: impact on estimates of progression and regression Open
Background White matter hyperintensity (WMH) progression is well documented; WMH regression is more contentious, which might reflect differences in defining WMH change. We compared four existing WMH change definitions in one population to …
View article: DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain
DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain Open
View article: Sex-Dependent Effects of Cardiometabolic Health and <i>APOE4</i> on Brain Age
Sex-Dependent Effects of Cardiometabolic Health and <i>APOE4</i> on Brain Age Open
This study indicates sex-dependent and time-dependent relationships between CMRs, APOE4 status, and brain age. Our findings highlight the necessity of sex-stratified analyses to elucidate the role of CMRs in individual aging traject…
View article: Incident Infarcts in Patients With Stroke and Cerebral Small Vessel Disease
Incident Infarcts in Patients With Stroke and Cerebral Small Vessel Disease Open
In the year after stroke in a population enriched for lacunar stroke, incident infarcts occurred in one-quarter and were associated with worse baseline SVD. Most incident infarcts detected on imaging did not correspond to clinical stroke/t…
View article: Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study
Examining the neurostructural architecture of intelligence: The Lothian Birth Cohort 1936 study Open
Examining underlying neurostructural correlates of specific cognitive abilities is practically and theoretically complicated by the existence of the positive manifold (all cognitive tests positively correlate): if a brain structure is asso…
View article: Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936
Life-course neighbourhood deprivation and brain structure in older adults: the Lothian Birth Cohort 1936 Open
Neighbourhood disadvantage may be associated with brain health but the importance of exposure at different stages of the life course is poorly understood. Utilising the Lothian Birth Cohort 1936, we explored the relationship between reside…
View article: Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health Open
View article: General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning
General and specific patterns of cortical gene expression as spatial correlates of complex cognitive functioning Open
Gene expression varies across the brain. This spatial patterning denotes specialised support for particular brain functions. However, the way that a given gene's expression fluctuates across the brain may be governed by general rules. Quan…
View article: Blood-based DNA methylation study of alcohol consumption
Blood-based DNA methylation study of alcohol consumption Open
Alcohol consumption is an important risk factor for multiple diseases. It is typically assessed via self-report, which is open to measurement error and bias. Instead, molecular data such as blood-based DNA methylation (DNAm) could be used …
View article: Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress
Magnetic Resonance Imaging Tissue Signatures Associated With White Matter Changes Due to Sporadic Cerebral Small Vessel Disease Indicate That White Matter Hyperintensities Can Regress Open
Background White matter hyperintensities (WMHs) might regress and progress contemporaneously, but we know little about underlying mechanisms. We examined WMH change and underlying quantitative magnetic resonance imaging tissue measures ove…
View article: Baseline predictors and clinical outcomes of incident infarcts in the year after a mild stroke
Baseline predictors and clinical outcomes of incident infarcts in the year after a mild stroke Open
Introduction: Factors associated with incident infarcts after stroke are unclear. We aimed to determine whether subsequent incident infarcts continue to develop one year post-stroke and how incident infarcts relate to baseline imaging feat…
View article: Impact of white matter hyperintensity regression on global cognition, processing speed and executive function
Impact of white matter hyperintensity regression on global cognition, processing speed and executive function Open
Introduction: White matter hyperintensities (WMH) are related to cognitive decline, particularly processing speed and executive functioning (EF). However, all cognitive domains might be affected. WMH can regress and this might have positiv…
View article: Impact of long-term white matter hyperintensity changes on mobility and dexterity
Impact of long-term white matter hyperintensity changes on mobility and dexterity Open
White matter hyperintensities (WMH), a common feature of cerebral small vessel disease, are related to worse clinical outcomes after stroke. We assessed the impact of white matter hyperintensity changes over 1 year after minor stroke on ch…
View article: Impact of White Matter Hyperintensity Changes on Cognition One Year After Mild Ischemic Stroke
Impact of White Matter Hyperintensity Changes on Cognition One Year After Mild Ischemic Stroke Open
Background White matter hyperintensities (WMH) are a main MRI feature of cerebral small vessel disease, and are associated with increased risk of stroke and dementia. Progression can lead to cognitive decline, but some evidence suggests th…
View article: Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health
Epigenetic scores of blood-based proteins as biomarkers of general cognitive function and brain health Open
Background Blood-based biomarkers of brain health could provide a cost-effective contribution to detecting individuals at risk of dementia. Epigenetic scores (EpiScores) for blood protein levels have previously associated with several dise…
View article: DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain
DNAm scores for serum GDF15 and NT-proBNP levels associate with a range of traits affecting the body and brain Open
Background Plasma growth differentiation factor 15 (GDF15) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) are cardiovascular biomarkers that associate with a range of diseases. Epigenetic scores (EpiScores) for GDF15 and NT-proB…