Susann Michanski
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View article: Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system
Adaptor protein complex 2 (AP2) participates in biogenesis and homeostasis of myelin sheaths in the central nervous system Open
Myelination of CNS axons requires oligodendrocytes to undergo extensive morphological changes by producing large amounts of myelin membrane with defined protein composition and structure. The formation of myelin sheaths thus involves effic…
View article: SynapseNet: Deep learning for automatic synapse reconstruction
SynapseNet: Deep learning for automatic synapse reconstruction Open
Electron microscopy is an important technique for the study of synaptic morphology and its relation to synaptic function. The data analysis for this task requires the segmentation of the relevant synaptic structures, such as synaptic vesic…
View article: Gating of hair cell Ca <sup>2+</sup> channels governs the activity of cochlear neurons
Gating of hair cell Ca <sup>2+</sup> channels governs the activity of cochlear neurons Open
Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear, the receptor potential of presynaptic inner hair cells (IHCs) covers the entire intensity range, while postsynaptic spiral ganglion neurons (SGN…
View article: 3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography
3D virtual histology of rodent and primate cochleae with multi-scale phase-contrast X-ray tomography Open
Multi-scale X-ray phase contrast tomography (XPCT) enables three-dimensional (3D), non-destructive imaging of intact small animal cochlea and apical cochlear turns. Here we report on post-mortem imaging of excised non-human primate and rod…
View article: Gating of hair cell Ca<sup>2+</sup>channels governs the activity of cochlear neurons
Gating of hair cell Ca<sup>2+</sup>channels governs the activity of cochlear neurons Open
Our sense of hearing processes sound intensities spanning six orders of magnitude. In the ear, postsynaptic spiral ganglion neurons (SGNs) tile this intensity range with their firing rate codes. Presynaptic inner hair cells (IHCs) vary Ca …
View article: SynapseNet: Deep Learning for Automatic Synapse Reconstruction
SynapseNet: Deep Learning for Automatic Synapse Reconstruction Open
Electron microscopy is an important technique for the study of synaptic morphology and its relation to synaptic function. The data analysis for this task requires the segmentation of the relevant synaptic structures, such as synaptic vesic…
View article: Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver
Defective mitochondrial COX1 translation due to loss of COX14 function triggers ROS-induced inflammation in mouse liver Open
View article: A Technique to Perform Structure–Function Analysis of Synapses
A Technique to Perform Structure–Function Analysis of Synapses Open
View article: Age-dependent structural reorganization of utricular ribbon synapses
Age-dependent structural reorganization of utricular ribbon synapses Open
In mammals, spatial orientation is synaptically-encoded by sensory hair cells of the vestibular labyrinth. Vestibular hair cells (VHCs) harbor synaptic ribbons at their presynaptic active zones (AZs), which play a critical role in molecula…
View article: Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing
Piccolino is required for ribbon architecture at cochlear inner hair cell synapses and for hearing Open
Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tirelessly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization …
View article: Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses
Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses Open
Ribbon synapses of cochlear inner hair cells (IHCs) are specialized to indefatigably transmit sound information at high rates. To understand the underlying mechanisms, structure-function analysis of the active zone (AZ) of these synapses i…
View article: Age-dependent structural reorganization of utricular ribbon synapses
Age-dependent structural reorganization of utricular ribbon synapses Open
In mammals, spatial orientation is synaptically-encoded by sensory hair cells of the vestibular labyrinth. Vestibular hair cells (VHCs) harbor synaptic ribbons at their presynaptic active zones (AZs), which play a critical role in molecula…
View article: Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses
Piccolino regulates the architecture of the ribbon at cochlear inner hair cell synapses Open
Cochlear inner hair cells (IHCs) form specialized ribbon synapses with spiral ganglion neurons that tireless-ly transmit sound information at high rates over long time periods with extreme temporal precision. This functional specialization…
View article: Author response: Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses
Author response: Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses Open
View article: Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses
Optogenetics and electron tomography for structure-function analysis of cochlear ribbon synapses Open
Ribbon synapses of cochlear inner hair cells (IHCs) are specialized to indefatigably transmit sound information at high rates. To understand the underlying mechanisms, structure-function analysis of the active zone (AZ) of these synapses i…
View article: Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea Open
View article: Macromolecular and electrical coupling between inner hair cells in the rodent cochlea
Macromolecular and electrical coupling between inner hair cells in the rodent cochlea Open
Inner hair cells (IHCs) are the primary receptors for hearing. They are housed in the cochlea and convey sound information to the brain via synapses with the auditory nerve. IHCs have been thought to be electrically and metabolically indep…
View article: Ultrastructural characterization of the first auditory synapse using super-resolution STED microscopy
Ultrastructural characterization of the first auditory synapse using super-resolution STED microscopy Open
The peripheral auditory system in rodents reaches its functional maturity within the postnatal days 12 – 14. This maturation involves the structural and functional remodeling of the inner hair cell (IHC) presynaptic active zones (AZ). This…
View article: Ultrastrukturelle Charakterisierung der ersten auditorischen Synapse mittels hochauflösender STED-Mikroskopie
Ultrastrukturelle Charakterisierung der ersten auditorischen Synapse mittels hochauflösender STED-Mikroskopie Open
Das periphere auditorische System der Maus entwickelt seine Funktionsbereitschaft in den ersten 12 – 14 postnatalen Tagen. Dieser Reifungsprozess beinhaltet sowohl eine strukturelle als auch funktionelle Re-Modellierung der präsynaptischen…
View article: Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea
Mapping developmental maturation of inner hair cell ribbon synapses in the apical mouse cochlea Open
Significance Hearing relies on temporally precise and indefatigable transmission of sensory information mediated by inner hair cell (IHC) ribbon synapses. Synaptic ribbons are electron-dense structures that tether numerous vesicles at the …
View article: Molecular and structural investigation of assembly, maturation and heterogeneity of inner hair cell ribbon synapses
Molecular and structural investigation of assembly, maturation and heterogeneity of inner hair cell ribbon synapses Open
Age-related hearing and balance impairments represent the most common sensory deficits in humans. Both senses rely on hair cell ribbon synapses, which are highly specialized to sustain continuous release of neurotransmitter filled synaptic…
View article: Vesicle sub‐pool organization at inner hair cell ribbon synapses
Vesicle sub‐pool organization at inner hair cell ribbon synapses Open
View article: The synaptic ribbon is critical for sound encoding at high rates and with temporal precision
The synaptic ribbon is critical for sound encoding at high rates and with temporal precision Open
We studied the role of the synaptic ribbon for sound encoding at the synapses between inner hair cells (IHCs) and spiral ganglion neurons (SGNs) in mice lacking RIBEYE (RBEKO/KO). Electron and immunofluorescence microscopy revealed a lack …
View article: Author response: The synaptic ribbon is critical for sound encoding at high rates and with temporal precision
Author response: The synaptic ribbon is critical for sound encoding at high rates and with temporal precision Open
Article Figures and data Abstract eLife digest Introduction Results Discussion Materials and methods References Decision letter Author response Article and author information Metrics Abstract We studied the role of the synaptic ribbon for …
View article: EF-hand protein Ca <sup>2+</sup> buffers regulate Ca <sup>2+</sup> influx and exocytosis in sensory hair cells
EF-hand protein Ca <sup>2+</sup> buffers regulate Ca <sup>2+</sup> influx and exocytosis in sensory hair cells Open
Significance Ca 2+ ions serve as a key cellular signal and are tightly controlled. One mechanism to limit free Ca 2+ ions is buffering by Ca 2+ -binding proteins, which are strongly expressed in sensory hair cells of the ear. Here we studi…