Susann Zilkenat
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View article: Dose‐dependent inactivation of <i>Plasmodium falciparum</i> in red blood cell concentrates by treatment with short‐wavelength ultraviolet light
Dose‐dependent inactivation of <i>Plasmodium falciparum</i> in red blood cell concentrates by treatment with short‐wavelength ultraviolet light Open
Background and Objectives Plasmodium species are naturally transmitted by Anopheles mosquitos. The parasite infects red blood cells (RBCs) and can be transfused with blood products. In non‐endemic areas, the main risk of infection arises f…
View article: Proliferation of psychrotrophic bacteria in cold‐stored platelet concentrates
Proliferation of psychrotrophic bacteria in cold‐stored platelet concentrates Open
Background and Objectives Platelet concentrates (PC) are stored at 20–24°C to maintain platelet functionality, which may promote growth of contaminant bacteria. Alternatively, cold storage of PC limits bacterial growth; however, data relat…
View article: Elucidating the architecture of the type III secretion system export apparatus
Elucidating the architecture of the type III secretion system export apparatus Open
Type III secretion systems (T3SS) are a widespread virulence factor in Gram negative bacteria. They contain an inner membrane spanning sub-complex termed the export apparatus, made up of five proteins. The export apparatus translocates eff…
View article: Models of SpaP, SpaR, SpaQ, SpaS, and PrgJ in the T3SS needle complex and its assembly.
Models of SpaP, SpaR, SpaQ, SpaS, and PrgJ in the T3SS needle complex and its assembly. Open
(A) Model of the central SpaP complex with surrounding export apparatus components SpaQ, SpaR, and SpaS, and direct connection to the inner rod formed by PrgJ. These results suggest that SpaP, SpaR, and PrgJ form the socket structure on th…
View article: Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus
Structural and Functional Characterization of the Bacterial Type III Secretion Export Apparatus Open
Bacterial type III protein secretion systems inject effector proteins into eukaryotic host cells in order to promote survival and colonization of Gram-negative pathogens and symbionts. Secretion across the bacterial cell envelope and injec…
View article: Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach
Determination of the Stoichiometry of the Complete Bacterial Type III Secretion Needle Complex Using a Combined Quantitative Proteomic Approach Open