Susanna Cogo
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View article: PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open
View article: Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis
Sequestosome-1 (SQSTM1/p62) as a target in dopamine catabolite-mediated cellular dyshomeostasis Open
View article: PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation.
PAK6 promotes neuronal autophagy by regulating TFEB nuclear translocation. Open
Autophagy is a highly conserved homeostatic process essential for the bulk degradation of cytoplasmic components and aggregated proteins. Multiple evidence indicates that impairment of (macro)autophagy leads to neurodegeneration, such as P…
View article: PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open
P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the phy…
View article: PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner
PAK6 rescues pathogenic LRRK2-mediated ciliogenesis and centrosomal cohesion defects in a mutation-specific manner Open
P21 activated kinase 6 (PAK6) is a serine-threonine kinase with physiological expression enriched in the brain and overexpressed in a number of human tumors. While the role of PAK6 in cancer cells has been extensively investigated, the phy…
View article: DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease
DOPAL initiates αSynuclein-dependent impaired proteostasis and degeneration of neuronal projections in Parkinson’s disease Open
View article: Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins
Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins Open
View article: LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease
LRRK2 kinase activity regulates GCase level and enzymatic activity differently depending on cell type in Parkinson’s disease Open
View article: The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation
The Roc domain of LRRK2 as a hub for protein-protein interactions: a focus on PAK6 and its impact on RAB phosphorylation Open
View article: On the corrosion, stress corrosion and cytocompatibility performances of ALD TiO2 and ZrO2 coated magnesium alloys
On the corrosion, stress corrosion and cytocompatibility performances of ALD TiO2 and ZrO2 coated magnesium alloys Open
Magnesium alloys are increasingly studied as materials for temporary implants. However, their high corrosion rate and susceptibility to corrosion-assisted cracking phenomena, such as stress corrosion cracking (SCC), continue to prevent the…
View article: The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson’s disease
The activities of LRRK2 and GCase are positively correlated in clinical biospecimens and experimental models of Parkinson’s disease Open
LRRK2 is a kinase involved in different cellular functions, including autophagy, endolysosomal pathways and vesicle trafficking. Mutations in LRRK2 cause autosomal dominant forms of Parkinson’s disease (PD). Heterozygous mutations in GBA1 …
View article: Modelling the functional genomics of Parkinson’s disease in<i>Caenorhabditis elegans</i>:<i>LRRK2</i>and beyond
Modelling the functional genomics of Parkinson’s disease in<i>Caenorhabditis elegans</i>:<i>LRRK2</i>and beyond Open
For decades, Parkinson’s disease (PD) cases have been genetically categorised into familial, when caused by mutations in single genes with a clear inheritance pattern in affected families, or idiopathic, in the absence of an evident monoge…
View article: DOPAL initiates αSynuclein-mediated impaired proteostasis in neuronal projections leading to enhanced vulnerability in Parkinson’s disease
DOPAL initiates αSynuclein-mediated impaired proteostasis in neuronal projections leading to enhanced vulnerability in Parkinson’s disease Open
Dopamine dyshomeostasis has been acknowledged to be among the determinants of nigrostriatal neuron degeneration in Parkinson’s disease (PD). Several studies in experimental models and postmortem PD patients underlined increasing levels of …
View article: On the evaluation of ALD TiO2, ZrO2 and HfO2 coatings on corrosion and cytotoxicity performances
On the evaluation of ALD TiO2, ZrO2 and HfO2 coatings on corrosion and cytotoxicity performances Open
View article: Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues
Divergent Effects of G2019S and R1441C LRRK2 Mutations on LRRK2 and Rab10 Phosphorylations in Mouse Tissues Open
Mutations in LRRK2 cause familial Parkinson’s disease and common variants increase disease risk. LRRK2 kinase activity and cellular localization are tightly regulated by phosphorylation of key residues, primarily Ser1292 and Ser935, which …
View article: Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins
Cytosolic sequestration of spatacsin by Protein Kinase A and 14-3-3 proteins Open
Mutations in SPG11 , encoding spatacsin, constitute the major cause of autosomal recessive Hereditary Spastic Paraplegia (HSP) with thinning of the corpus callosum. Previous studies showed that spatacsin orchestrates cellular traffic event…
View article: Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism
Co-occurring WARS2 and CHRNA6 mutations in a child with a severe form of infantile parkinsonism Open
View article: Investigating the role of the Roc/GTPase domain of the Parkinson's disease kinase LRRK2 in regulating protein function and activity
Investigating the role of the Roc/GTPase domain of the Parkinson's disease kinase LRRK2 in regulating protein function and activity Open
Parkinson’s disease (PD) is the second most common neurodegenerative disease of the modern era. Although PD aetiology is still uncertain, approximately 10% of patients suffer from a monogenic form of PD. Mutations in Leucine-rich repeat ki…
View article: PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2
PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2 Open
Mutations in Leucine-rich repeat kinase 2 (LRRK2) are associated with Parkinson's disease (PD) and, as such, LRRK2 is considered a promising therapeutic target for age-related neurodegeneration. Although the cellular functions of LRRK2 in …
View article: Leucine Rich Repeat Kinase 2: beyond Parkinson’s and beyond kinase inhibitors
Leucine Rich Repeat Kinase 2: beyond Parkinson’s and beyond kinase inhibitors Open
Leucine Rich Repeat Kinase 2 (LRRK2) is a multidomain enzyme with dual kinase and GTPase activities. Following the identification of mutations in the LRRK2 gene linked to familial Parkinson’s disea...
View article: LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate
LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate Open
Given that the most common Parkinson's disease LRRK2 G2019S mutation displays increased kinase activity, our results suggest that mutant LRRK2 may impair synaptic vesicle dynamics via aberrant phosphorylation of NSF.