Susanna Diamanti
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View article: Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)
Multicenter Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC) Open
BACKGROUND: Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute ischemic stroke, although clinical evidence remains conflicting. The TRICS BASIC study (Multicenter Translational Trial of Remot…
View article: Epidemiology of Oral Cancer in Cyprus: A Population-Based Cancer Registry Study and Policy Implications
Epidemiology of Oral Cancer in Cyprus: A Population-Based Cancer Registry Study and Policy Implications Open
View article: Head-down tilt 15° increases cerebral perfusion before recanalization in acute ischemic stroke. A pre-clinical MRI study
Head-down tilt 15° increases cerebral perfusion before recanalization in acute ischemic stroke. A pre-clinical MRI study Open
We investigated the therapeutic effect of head-down tilt at -15° (HDT15) on cerebral collateral flow and early infarct growth in a rat model of large vessel occlusion stroke, using multi-modal MRI. Endovascular occlusion of the proximal mi…
View article: Effectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study
Effectiveness and safety of dual antiplatelet therapy in patients with minor ischemic stroke or transient ischemic attack and cancer: A secondary analysis of the READAPT study Open
Introduction: Patients with ischemic stroke or transient ischemic attack (TIA) and cancer face unique risks of recurrent ischemic events and bleeding. It is unclear whether this increased risk is present even in patients with minor ischemi…
View article: Real‐World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis—Insights From the <scp>READAPT</scp> Study
Real‐World Dual Antiplatelet Therapy Use Exceeds Randomized Trials Boundaries With Possible Safety Issues in Patients With Large Artery Atherosclerosis—Insights From the <span>READAPT</span> Study Open
Background and Aim According to randomized controlled trials (RCTs), dual antiplatelet therapy (DAPT) is more effective for secondary prevention of ischemic events attributable to large artery atherosclerosis (LAA) than other mechanisms. W…
View article: Multi-center Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC)
Multi-center Translational Trial of Remote Ischemic Conditioning in Acute Ischemic Stroke (TRICS BASIC) Open
Background Basic science studies have reported remote ischemic conditioning (RIC) as neuroprotective in acute ischemic stroke, while clinical evidence remains conflicting. The TRICS BASIC study investigated the efficacy and safety of RIC i…
View article: Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment
Recanalization Outcomes and Procedural Complications in Patients With Acute Ischemic Stroke and COVID-19 Receiving Endovascular Treatment Open
View article: Prognostic Value of Signal Abnormalities on Brain <scp>MRI</scp> in Post‐Anoxic Super‐Refractory Status Epilepticus: A Single‐Center Retrospective Study
Prognostic Value of Signal Abnormalities on Brain <span>MRI</span> in Post‐Anoxic Super‐Refractory Status Epilepticus: A Single‐Center Retrospective Study Open
Background Epileptiform activity, including status epilepticus (SE), occurs in up to one‐third of comatose survivors of cardiac arrest and may predict poor outcome. The relationship between SE and hypoxic–ischemic brain injury (HIBI) is no…
View article: Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry
Platelet inhibition strategies in rescue stenting after failed thrombectomy: a large retrospective multicenter registry Open
Background: Rescue stenting (RS) is a bailout strategy for failed thrombectomy. Optimal platelet inhibition strategy after RS remains unclear. Objectives: We aimed to describe and compare different platelet inhibition strategies during/aft…
View article: Patients with Mucositis due to Chemotherapy: A Literature Review
Patients with Mucositis due to Chemotherapy: A Literature Review Open
View article: Defining short-term outcomes of minor ischemic stroke due to small artery occlusion in the era of dual antiplatelet treatment: A READAPT study sub-analysis
Defining short-term outcomes of minor ischemic stroke due to small artery occlusion in the era of dual antiplatelet treatment: A READAPT study sub-analysis Open
Our findings show overall favorable short-term prognosis after SAO-MIS treated with DAPT. Future studies should investigate factors associated with residual stroke risk and long-term outcomes of SAO-MIS.
View article: Head down tilt 15° increases cerebral perfusion before recanalization in acute ischemic stroke. A pre-clinical MRI study
Head down tilt 15° increases cerebral perfusion before recanalization in acute ischemic stroke. A pre-clinical MRI study Open
We investigated the therapeutic effect of head down positioning at −15° (head down tilt; HDT15) on cerebral collateral flow and infarct growth in a rat model of large vessel occlusion (LVO) stroke, using multi-modal MRI. Twenty-eight Wista…
View article: Beyond RCTs: Short-term dual antiplatelet therapy in secondary prevention of ischemic stroke and transient ischemic attack
Beyond RCTs: Short-term dual antiplatelet therapy in secondary prevention of ischemic stroke and transient ischemic attack Open
Background and purpose: Randomized controlled trials (RCTs) proved the efficacy of short-term dual antiplatelet therapy (DAPT) in secondary prevention of minor ischemic stroke or high-risk transient ischemic attack (TIA). We aimed at evalu…
View article: A REAl-life study on short-term Dual Antiplatelet treatment in Patients with ischemic stroke or Transient ischemic attack (READAPT)
A REAl-life study on short-term Dual Antiplatelet treatment in Patients with ischemic stroke or Transient ischemic attack (READAPT) Open
Background and purpose Clinical trials proved the efficacy of short-term dual antiplatelet therapy (DAPT) in secondary prevention of minor ischemic stroke or high-risk transient ischemic attack (TIA). In clinical practice, the use of short…
View article: Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes
Effect of Asymptomatic and Symptomatic COVID-19 on Acute Ischemic Stroke Revascularization Outcomes Open
BACKGROUND: The association of COVID-19 with higher bleeding risk and worse outcomes in acute ischemic stroke (AIS) undergoing revascularization may be related to the presence of infection symptoms. We aimed to assess the safety and outcom…
View article: Incidence and Long-term Functional Outcome of Neurologic Disorders in Hospitalized Patients With COVID-19 Infected With Pre-Omicron Variants
Incidence and Long-term Functional Outcome of Neurologic Disorders in Hospitalized Patients With COVID-19 Infected With Pre-Omicron Variants Open
Incidence of COVID-associated neurologic disorders decreased during the prevaccination phase of the pandemic. Long-term functional outcome was favorable in most neuro-COVID disorders, although mild symptoms commonly lasted more than 6 mont…
View article: Head Down Tilt 15° in Acute Ischemic Stroke with Poor Collaterals: A Randomized Preclinical Trial
Head Down Tilt 15° in Acute Ischemic Stroke with Poor Collaterals: A Randomized Preclinical Trial Open
Cerebral collaterals are recruited after arterial occlusion with a protective effect on tissue outcome in acute ischemic stroke. Head down tilt 15° (HDT15) is a simple, low cost and accessible procedure that could be applied as an emergenc…
View article: Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke
Divergence Between Clinical Trial Evidence and Actual Practice in Use of Dual Antiplatelet Therapy After Transient Ischemic Attack and Minor Stroke Open
Background: Randomized controlled trials (RCTs) proved that short-term (21–90 days) dual antiplatelet therapy (DAPT) reduces the risk of early ischemic recurrences after a noncardioembolic minor stroke or high-risk transient ischemic attac…
View article: Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke
Harmonization of sensorimotor deficit assessment in a registered multicentre pre-clinical randomized controlled trial using two models of ischemic stroke Open
Multicentre preclinical randomized controlled trials (pRCTs) are a valuable tool to improve experimental stroke research, but are challenging and therefore underused. A common challenge regards the standardization of procedures across cent…
View article: Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19
Safety and Outcome of Revascularization Treatment in Patients With Acute Ischemic Stroke and COVID-19 Open
The study was registered under ClinicalTrials.gov identifier NCT04895462.
View article: Selective Cerebrospinal Fluid Hypothermia: Bioengineering Development and In Vivo Study of an Intraventricular Cooling Device (V-COOL)
Selective Cerebrospinal Fluid Hypothermia: Bioengineering Development and In Vivo Study of an Intraventricular Cooling Device (V-COOL) Open
View article: Neurovascular and infectious disease phenotype of acute stroke patients with and without COVID-19
Neurovascular and infectious disease phenotype of acute stroke patients with and without COVID-19 Open
Background The infectious disease phenotype of acute stroke associated with COVID-19 has been poorly characterized. Objective We investigated the neurovascular and infectious disease phenotype of stroke patients with and without COVID-19 i…
View article: Dataset related to article "Head down tilt 15° in experimental intracerebral hemorrhage: a randomized noninferiority safety trial"
Dataset related to article "Head down tilt 15° in experimental intracerebral hemorrhage: a randomized noninferiority safety trial" Open
The database contains animal models MRI in DICOM and NIfTI file format
View article: Dataset related to article "Head down tilt 15° in experimental intracerebral hemorrhage: a randomized noninferiority safety trial"
Dataset related to article "Head down tilt 15° in experimental intracerebral hemorrhage: a randomized noninferiority safety trial" Open
The database contains animal models MRI in DICOM and NIfTI file format
View article: Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients
Neutrophils predominate the immune signature of cerebral thrombi in COVID-19 stroke patients Open
View article: Multi-Center Randomized Phase II Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies (TRICS-9): Study Design and Protocol
Multi-Center Randomized Phase II Clinical Trial on Remote Ischemic Conditioning in Acute Ischemic Stroke Within 9 Hours of Onset in Patients Ineligible to Recanalization Therapies (TRICS-9): Study Design and Protocol Open
Aim: To assess the efficacy of remote ischemic conditioning (RIC) in patients with ischemic stroke within 9 h of onset, that are not candidates for recanalization therapies. Sample Size Estimates: A sample size of 80 patients (40 in each a…
View article: SARS-CoV-2 infection and acute ischemic stroke in Lombardy, Italy
SARS-CoV-2 infection and acute ischemic stroke in Lombardy, Italy Open
Objective To characterize patients with acute ischemic stroke related to SARS-CoV-2 infection and assess the classification performance of clinical and laboratory parameters in predicting in-hospital outcome of these patients. Methods In t…
View article: Impact of SARS-CoV-2 on reperfusion therapies for acute ischemic stroke in Lombardy, Italy: the STROKOVID network
Impact of SARS-CoV-2 on reperfusion therapies for acute ischemic stroke in Lombardy, Italy: the STROKOVID network Open
View article: ALS Mimics due to Affection of the Cervical Spine: From Common Compressive Myelopathy to Rare CSF Epidural Collection
ALS Mimics due to Affection of the Cervical Spine: From Common Compressive Myelopathy to Rare CSF Epidural Collection Open
Amyotrophic lateral sclerosis (ALS) is a clinically heterogeneous disease, with chameleon presentations and several mimics. Considering the poor prognosis of ALS, their precise and timely identification is pivotal. Affection of the cervica…
View article: Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis
Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis Open