Explanipedia

Pre-extraction affects the mycelial bioconversion potential of Typha spp. and Salix spp. biomass residues Open

Sylwia Adamczyk, Francesco Meneguzzo, Luca Tagliavento, Kalle Kaipanen, Petri Kilpeläinen , et al. · 2025

The effect of formulation composition and flow conditions on the robustness of semisolid extrusion 3D printing: a case study on poorly water-soluble itraconazole for oral dosage form production Open

Atte Junnila, Oscar Henriksson, Ardaneh Fatemeh, Eero Immonen, Maha F. Emam , et al. · 2025

Semisolid extrusion 3D printing is a manufacturing method that has shown promising results in precise production of patient specific dosage forms. Drug nanocrystals, where the particle size of the drug is in the nanometer range, is an attr…

Storage stability of spray-dried flaxseed oil powders protected by wood hemicelluloses – Part 1: Physical properties and initial stage oxidation Open

Thao M. Ho, Mari Lehtonen, Heikki Räikkönen, Abedalghani Halahlah, Kirsi S. Mikkonen · 2025

Polyunsaturated fatty acids, abundant in flaxseed oil (FO), easily oxidize, requiring stabilization preferably through encapsulation. Wood hemicelluloses, including galactoglucomannans (GGM) and glucuronoxylans (GX), effectively protect FO…

Interfacial Properties of Surface-Modified Lignin Nanoparticles Open

Mina Zare, Patrícia Figueiredo, Maarit H. Lahtinen, Kristiina Hildén, Sami Hietala , et al. · 2025

The interfacial properties of surface-modified lignin nanoparticles (LNPs) through the adsorption of various compounds or grafting of different ligands dictate their uses and potential applications in life sciences. In this study, we inves…

Postharvest Dynamics of Photosynthesis in Fresh‐Cut Lettuce Open

Priscille Steensma, Alexey Shapiguzov, Leevi Annala, Julia P. Vainonen, Kirsi S. Mikkonen , et al. · 2025

Increasing the availability of fresh vegetables and reducing food waste are essential for healthy and sustainable production. However, fresh‐cut vegetables such as lettuce ( Lactuca sativa L.) often experience rapid quality loss after harv…

Atomic Force Microscopy of Emulsions and Their Interfacial Nanoparticles Open

Ville A. Lovikka, Lin Chen, Patrícia Figueiredo, Kirsi S. Mikkonen · 2025

Liquid–liquid interfaces and interfacially entrapped nanoparticles are ubiquitous in nature and technology. Their importance in the industry is rising because nanoparticle‐stabilized emulsions can be designed to be more stable, ecological,…

Distinct post-harvest deterioration pathways caused by light vs dark storage of fresh-cut lettuce packed in modified atmosphere. Open

Priscille Steensma, Fanny Widjaja, Sitaram Rajaraman, Leevi Annala, Arto Klami , et al. · 2025

Modulating the Spontaneous Adsorption of Lignin Nanoparticle at Oil‐Water Interfaces Open

Danila Morais de Carvalho, Maarit H. Lahtinen, Patrícia Figueiredo, Sami P. Hirvonen, Sami Hietala , et al. · 2025

The performance of (nano)particles in the stabilization of Pickering emulsions depends on their physicochemical features. Therefore, synthetic particles are commonly applied in Pickering stabilization, despite the environmental issues thei…

Spontaneous and Laccase‐Assisted Adsorption of Hemicelluloses Rendering Colloidal Stability of Lignin Nanoparticles at Low pH Open

Patrícia Figueiredo, Danila Morais de Carvalho, Kristiina Hildén, Maarit H. Lahtinen, Kirsi S. Mikkonen · 2025

Functionalizing lignin nanoparticles (LNPs) is an attractive strategy to improve their properties and expand their range of applications. However, conventional approaches to achieve such modifications are done using environmentally and ene…

Composition and distribution of phenolic compounds of optimized bilberry microcapsules using wood hemicelluloses as protecting materials Open

Abedalghani Halahlah, Lisbeth Garbrecht Thygesen, Miikka Olin, Vieno Piironen, Kirsi S. Mikkonen , et al. · 2025

Bilberry anthocyanins, known for their antioxidant and functional properties, are highly sensitive to processing conditions, which limits their applications in the food and nutraceutical industries. In this study, we systematically optimiz…

Pre-Extraction Affects the Mycelial Bioconversion Potential of Typha Spp. And Salix Spp. Biomass Residues Open

Peter Petros, Pauliina Lankinen, Sylwia Adamczyk, Francesco Meneguzzo, Luca Tagliavento , et al. · 2025

Pseudo-3D HSQC0, a method to create a true 2D HSQC0-plane. Application to softwood extract analysis Open

Maarit H. Lahtinen, Tuomas Niemi-Aro, Danila Morais de Carvalho, Kirsi S. Mikkonen, Ilkka Kilpeläinen , et al. · 2024

Pseudo-3D HSQC₀ provides an alternative and easy way to record and analyze quantitative HSQC₀-data. In the original time-zero extrapolated ¹H-¹³C HSQC (HSQC₀), three separate 2D consta…

Non-targeted LC-MS metabolomics reveal shifts from wound-induced enzymatic browning to lignification during extended storage of fresh-cut lettuce in modified atmosphere packaging Open

Fanny Widjaja, Priscille Steensma, Leevi Annala, Arto Klami, Saijaliisa Kangasjärvi , et al. · 2024

Modified Atmosphere Packaging (MAP) is a conventional method used to prolong the shelf-life of fresh-cut vegetables, including lettuce. However, MAP-stored lettuce remains perishable, and its deterioration mechanism is not fully understood…

Role of extractive compounds in emulsion stabilisation capacity of wood hemicelluloses Open

Tiina Belt, Maarit H. Lahtinen, Jaana Liimatainen, Risto Korpinen, Kirsi S. Mikkonen , et al. · 2024

Hemicellulose-rich extracts obtained by pressurised hot water extraction of wood residues show promise as emulsion stabilisers. However, pressurised hot water extracts (PHWEs) from wood also contain lower molecular weight extractive compon…

Wood hemicelluloses as protective materials for preserving the viability of probiotic Lacticaseibacillus rhamnosus GG during spray drying Open

Suutari Eveliina, Abedalghani Halahlah, Heikki Räikkönen, Amin Yousefvand, Per E. J. Saris , et al. · 2024

Wood hemicelluloses from forest industry side-streams are promising economic and sustainable alternatives for encapsulating bioactive compounds. This study explores their suitability for probiotic encapsulation, specifically for maintainin…

Silver Nanoparticles (AgNPs) Uptake by Caveolae-Dependent Endocytosis is Responsible for Their Selective Effect Towards Castration Resistant Prostate Cancer Open

Mariana Morais, Francisca Dias, Patrícia Figueiredo, Inês Ferreira Dias Tavares, Carla Escudeiro , et al. · 2024

This study shows the potential of these AgNPs as a new therapeutic approach directed to CRPC patients, uncovers caveolae-dependent endocytosis as the uptake mechanism of these AgNPs and highlights deregulation of Cav1 and Cav2 expression a…

Protective role of wood hemicelluloses: Enhancing yeast probiotics survival in spray drying and storage Open

Thao M. Ho, Amin Yousefvand, Heikki Suhonen, Per E. J. Saris, Kirsi S. Mikkonen · 2024

Wood hemicelluloses, specifically galactoglucomannans (GGM) and glucuronoxylans (GX) are investigated for their efficacy in spray-dried microencapsulation of Saccharomyces cerevisiae subsp. boulardii (SB). This study demonstrated that GGM …

The two-faced functionality of birch glucuronoxylan in an emulsion-based carrier of vitamin D3 Open

Felix Abik, Thao M. Ho, Mari Lehtonen, Mark Philo, Catherine Booth , et al. · 2024

Emulsions are commonly used to fortify beverages with oil-soluble nutrients. Such emulsions must be physically stable, prevent the cargo nutrient from chemical degradation, and release the nutrient at the right time during digestion. Wood …

Use of dairy industry side-stream lactose for tablet manufacturing − proof of concept study Open

Anssi-Pekka Karttunen, Atte Junnila, Eetu Myöhänen, E. Harju, Chee Xuan , et al. · 2024

During recent years there have been shortages of certain drugs due to problems in raw material supply. These are often related to active ingredients but could also affect excipients. Lactose is one of the most used excipients in tableting …

Protective Effects of Polysaccharides on Antifungal Activity of Bread Waste-derived Bioactive Peptides During Freeze Drying Open

Daniele Santangelo, Abedalghani Halahlah, Idowu Onyinye Adesanya, Kirsi S. Mikkonen, Rossana Coda , et al. · 2024

Bioactive peptides (BPs) derived from agri-food side-streams display great potential as functional ingredients and nutraceuticals. However, BPs can be susceptible to environmental stressors and food processing conditions and typically exis…

Adsorption study on the formation of interfacial layers based on birch glucuronoxylans Open

Felix Abik, Katariina Solin, Sami Hietala, Orlando J. Rojas, Thao M. Ho , et al. · 2024

Combination of carboxymethylcellulose and wood hemicelluloses to enhance encapsulation efficiency and microcapsule wall thickness Open

Abedalghani Halahlah, Felix Abik, Heikki Suhonen, Heikki Räikkönen, Vieno Piironen , et al. · 2024

Wood hemicelluloses have been used as a wall material for spray-dried microencapsulation of polyphenols. Nevertheless, their incomplete water solubility could negatively impact their encapsulation efficiency (EE) and the formation of a com…

Enzymatic crosslinking of lignin nanoparticles and nanocellulose in cryogels improves adsorption of pharmaceutical pollutants Open

Melissa B. Agustin, Maarit H. Lahtinen, Marianna Kemell, Erfan Oliaei, Kirsi S. Mikkonen , et al. · 2024

Pharmaceuticals, designed for treating diseases, ironically endanger humans and aquatic ecosystems as pollutants. Adsorption-based wastewater treatment could address this problem, however, creating efficient adsorbents remains a challenge.…

Polyphenol- and Glucuronoxylan-Rich Fiber Extract from Birch (<i>Betula</i> sp.) Wood Regulates Colonic Barrier Function and Cell Proliferation in Healthy Rats Open

Emma Kynkäänniemi, Jere Lindén, Suchaya Ngambundit, Laura Aliisa Saarimäki, Dario Greco , et al. · 2024

Birch wood-derived fiber extracts containing glucuronoxylans (GX) and polyphenols show potential for various food technological applications. This study investigated the effect of two extracts, GXpoly and pureGX, differing in lignin conten…

Lignin Nanoparticles Show Spontaneous Adsorption at the Interface of Pickering Systems Open

Danila Morais de Carvalho, Maarit H. Lahtinen, Patrícia Figueiredo, Sami P. Hirvonen, Sami Hietala , et al. · 2024

Lignin Nanoparticles Show Spontaneous Adsorption at the Interface of Pickering Systems Open

Danila Morais de Carvalho, Maarit H. Lahtinen, Patrícia Figueiredo, Sami P. Hirvonen, Sami Hietala , et al. · 2024

From waste to a resource? Hemicelluloses enhance the dissolution and stability of the amorphous state of carbamazepine Open

Kirsi S. Mikkonen, Reetta Latukka, Danila Morais de Carvalho, Riikka Laitinen · 2023

Both synthetic and natural polymers are used as excipients in various pharmaceutical preparations. Natural polymers offer advantages, such as abundant availability, cost-effectiveness, non-toxicity, biocompatibility, and biodegradability. …

Silver Nanoparticles (AgNPs) as Enhancers of Everolimus and Radiotherapy Sensitivity on Clear Cell Renal Cell Carcinoma Open

Mariana Morais, Vera Machado, Patrícia Figueiredo, Francisca Dias, Rogéria Craveiro , et al. · 2023

Nanomedicine’s advent has promised to revolutionize different biomedical fields, including oncology. Silver Nanoparticles (AgNPs) showed promising results in different tumor models. Clear cell Renal Cell Carcinoma (ccRCC) is especially cha…

Metabolic Fate of Lignin in Birch Glucuronoxylan Extracts as Dietary Fiber Studied in a Rat Model Open

Maarit H. Lahtinen, Emma Kynkäänniemi, Ching Jian, Anne Salonen, Anne‐Maria Pajari , et al. · 2023

Scope While previously considered inert, recent studies suggest lignin metabolism with unknown metabolic fates is occurring in the gastrointestinal tract of several animal models. This study focuses on analyzing the potential metabolites o…

Gel characteristics of low-acetyl spruce galactoglucomannans Open

Henrik Karppanen, Abedalghani Halahlah, Petri Kilpeläinen, Kirsi S. Mikkonen, Thao M. Ho · 2023

Galactoglucomannans (GGM) recovered from abundant forest industry side-streams has been widely recognized as a renewable hydrocolloid. The low molar mass and presence of O-acetyl side-groups results in low viscous dispersions and weak inte…

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