Susannah J. Sample
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View article: Longitudinal single-cell profiling in canine DLBCL reveals regulatory networks driving chemotherapy resistance.
Longitudinal single-cell profiling in canine DLBCL reveals regulatory networks driving chemotherapy resistance. Open
Diffuse Large B Cell Lymphoma (DLBCL) is the most common lymphoid malignancy in both humans and dogs, characterized by clinical and biological heterogeneity. While standard chemotherapy induces clinical remission in many patients, the majo…
View article: Accuracy of genome-enabled polygenic risk score prediction of cruciate ligament rupture risk in the Labrador Retriever
Accuracy of genome-enabled polygenic risk score prediction of cruciate ligament rupture risk in the Labrador Retriever Open
Introduction Canine cruciate ligament rupture (CR) is a common, complex, polygenic, orthopaedic disease in dogs that results in serious financial burden and patient morbidity even in the face of surgical correction. The goal of this study …
View article: Protocol for direct reprogramming of canine fibroblasts to induced motor neurons
Protocol for direct reprogramming of canine fibroblasts to induced motor neurons Open
Direct reprogramming of canine fibroblasts to induced motor neurons in vitro opens the door to molecular characterization, functional analysis, and therapeutic screening of canine age-related neurodegenerative diseases. Here, we present a …
View article: Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans
Cross-species analysis of genetic architecture and polygenic risk scores for non-contact ACL rupture in dogs and humans Open
Non-contact anterior cruciate ligament (ACL) rupture is a common serious orthopaedic disease in humans and dogs. Familial risk has been recognized in both species but interactions between genetic effects and environmental risk are not unde…
View article: Age of neutering contributes to risk of cruciate ligament rupture in Labrador Retrievers
Age of neutering contributes to risk of cruciate ligament rupture in Labrador Retrievers Open
OBJECTIVE Cruciate ligament rupture (CR) in Labrador Retrievers is a complex polygenic disease with high heritability. The environmental contribution to CR risk remains poorly characterized. An accurate genetic risk test for CR in the Labr…
View article: Pathologic classification of a late‐onset peripheral neuropathy in a spontaneous Labrador retriever dog model
Pathologic classification of a late‐onset peripheral neuropathy in a spontaneous Labrador retriever dog model Open
Late‐onset peripheral neuropathy (LPN) is a heritable canine neuropathy commonly found in Labrador retrievers and is characterized by laryngeal paralysis and pelvic limb paresis. Our objective was to establish canine LPN as a model for hum…
View article: Neurofilament light chain concentration does not correlate with disease status in Labrador Retrievers affected with idiopathic laryngeal paralysis
Neurofilament light chain concentration does not correlate with disease status in Labrador Retrievers affected with idiopathic laryngeal paralysis Open
OBJECTIVE The aim of this study was to investigate whether plasma neurofilament light chain (pNfL) concentration was altered in Labrador Retrievers with idiopathic laryngeal paralysis (ILP) compared to a control population. A secondary aim…
View article: Genetic architecture and polygenic risk score prediction of degenerative suspensory ligament desmitis (DSLD) in the Peruvian Horse
Genetic architecture and polygenic risk score prediction of degenerative suspensory ligament desmitis (DSLD) in the Peruvian Horse Open
Introduction: Spontaneous rupture of tendons and ligaments is common in several species including humans. In horses, degenerative suspensory ligament desmitis (DSLD) is an important acquired idiopathic disease of a major energy-storing ten…
View article: Selection signature analyses and genome-wide association reveal genomic hotspot regions that reflect differences between breeds of horse with contrasting risk of degenerative suspensory ligament desmitis
Selection signature analyses and genome-wide association reveal genomic hotspot regions that reflect differences between breeds of horse with contrasting risk of degenerative suspensory ligament desmitis Open
Degenerative suspensory ligament desmitis is a progressive idiopathic condition that leads to scarring and rupture of suspensory ligament fibers in multiple limbs in horses. The prevalence of degenerative suspensory ligament desmitis is br…
View article: Impact of the Surgical Environment on the Incidence, Timing, and Severity of Complications Associated With Oromaxillofacial Oncologic Surgery in Dogs
Impact of the Surgical Environment on the Incidence, Timing, and Severity of Complications Associated With Oromaxillofacial Oncologic Surgery in Dogs Open
Numerous reports describe complication rates associated with oromaxillofacial oncologic surgery in dogs, however, investigation regarding the impact of the surgical environment on the incidence of complications is under reported. The objec…
View article: Biologically Enhanced Genome-Wide Association Study Provides Further Evidence for Candidate Loci and Discovers Novel Loci That Influence Risk of Anterior Cruciate Ligament Rupture in a Dog Model
Biologically Enhanced Genome-Wide Association Study Provides Further Evidence for Candidate Loci and Discovers Novel Loci That Influence Risk of Anterior Cruciate Ligament Rupture in a Dog Model Open
Anterior cruciate ligament (ACL) rupture is a common condition that disproportionately affects young people, 50% of whom will develop knee osteoarthritis (OA) within 10 years of rupture. ACL rupture exhibits both hereditary and environment…
View article: Analysis of copy number variation in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture
Analysis of copy number variation in dogs implicates genomic structural variation in the development of anterior cruciate ligament rupture Open
Anterior cruciate ligament (ACL) rupture is an important condition of the human knee. Second ruptures are common and societal costs are substantial. Canine cranial cruciate ligament (CCL) rupture closely models the human disease. CCL ruptu…
View article: Bayesian and Machine Learning Models for Genomic Prediction of Anterior Cruciate Ligament Rupture in the Canine Model
Bayesian and Machine Learning Models for Genomic Prediction of Anterior Cruciate Ligament Rupture in the Canine Model Open
Anterior cruciate ligament (ACL) rupture is a common, debilitating condition that leads to early-onset osteoarthritis and reduced quality of human life. ACL rupture is a complex disease with both genetic and environmental risk factors. Cha…
View article: Late‐onset laryngeal paralysis: Owner perception of quality of life and cause of death
Late‐onset laryngeal paralysis: Owner perception of quality of life and cause of death Open
Background Late‐onset laryngeal paralysis (LoLP) is an idiopathic disease of older dogs, and is common in the Labrador Retriever. Owner perspective of how LoLP affects their pet's quality of life (QOL), the degree to which LoLP is perceive…
View article: Contribution of Habitual Activity to Cruciate Ligament Rupture in Labrador Retrievers
Contribution of Habitual Activity to Cruciate Ligament Rupture in Labrador Retrievers Open
Objective The aim of this study was to describe the contribution of signalment and habitual activity in the development of cruciate ligament rupture (CR) in Labrador Retrievers. Study Design Four hundred and twelve client-owned purebred La…
View article: Genome-wide association studies and genetic testing: understanding the science, success, and future of a rapidly developing field
Genome-wide association studies and genetic testing: understanding the science, success, and future of a rapidly developing field Open
Dog owners are increasingly interested in using commercially available testing panels to learn about the genetics of their pets, both to identify breed ancestry and to screen for specific genetic diseases. Helping owners interpret and unde…
View article: Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model
Multivariate genome-wide association analysis identifies novel and relevant variants associated with anterior cruciate ligament rupture risk in the dog model Open
These results did not overlap with our previous GWAS, which is reflective of the different methods used, and supports the need for further work. The results of the present study are highly relevant to ACLR pathogenesis, and identify potent…
View article: Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs
Use of a platelet-rich plasma-collagen scaffold as a bioenhanced repair treatment for management of partial cruciate ligament rupture in dogs Open
Dogs are commonly affected with cruciate ligament rupture (CR) and associated osteoarthritis (OA), and frequently develop a second contralateral CR. Platelet rich plasma (PRP) is a component of whole blood that contains numerous growth fac…
View article: Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading
Temporal mechanically-induced signaling events in bone and dorsal root ganglion neurons after in vivo bone loading Open
Mechanical signals play an integral role in the regulation of bone mass and functional adaptation to bone loading. The osteocyte has long been considered the principle mechanosensory cell type in bone, although recent evidence suggests the…
View article: Radiographic and magnetic resonance imaging predicts severity of cruciate ligament fiber damage and synovitis in dogs with cranial cruciate ligament rupture
Radiographic and magnetic resonance imaging predicts severity of cruciate ligament fiber damage and synovitis in dogs with cranial cruciate ligament rupture Open
Cruciate ligament rupture (CR) and associated osteoarthritis (OA) is a common condition in dogs. Dogs frequently develop a second contralateral CR. This study tested the hypothesis that the degree of stifle synovitis and cranial cruciate l…
View article: Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture
Genome-wide association analysis in dogs implicates 99 loci as risk variants for anterior cruciate ligament rupture Open
Anterior cruciate ligament (ACL) rupture is a common condition that can be devastating and life changing, particularly in young adults. A non-contact mechanism is typical. Second ACL ruptures through rupture of the contralateral ACL or rup…
View article: Variance associated with walking velocity during force platform gait analysis of a heterogeneous sample of clinically normal dogs
Variance associated with walking velocity during force platform gait analysis of a heterogeneous sample of clinically normal dogs Open
OBJECTIVE To determine whether walking at specific ranges of absolute and relative (V*) velocity would aid efficient capture of gait trial data with low ground reaction force (GRF) variance in a heterogeneous sample of dogs. ANIMALS 17 cli…
View article: Clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis: 13 cases (2004–2012)
Clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis: 13 cases (2004–2012) Open
OBJECTIVE To evaluate the clinical features and pathological joint changes in dogs with erosive immune-mediated polyarthritis (IMPA). DESIGN Retrospective case series. ANIMALS 13 dogs with erosive IMPA and 66 dogs with nonerosive IMPA. PRO…
View article: Autologous Bone Marrow-Derived Mesenchymal Stem Cells Modulate Molecular Markers of Inflammation in Dogs with Cruciate Ligament Rupture
Autologous Bone Marrow-Derived Mesenchymal Stem Cells Modulate Molecular Markers of Inflammation in Dogs with Cruciate Ligament Rupture Open
Mid-substance rupture of the canine cranial cruciate ligament rupture (CR) and associated stifle osteoarthritis (OA) is an important veterinary health problem. CR causes stifle joint instability and contralateral CR often develops. The dog…
View article: Metallosis with pseudotumour formation: Long-term complication following cementless total hip replacement in a dog
Metallosis with pseudotumour formation: Long-term complication following cementless total hip replacement in a dog Open
Summary Case description: A 10-year-old female Belgian Teruven dog was presented to our clinic for total hip revision following a diagnosis of implant (cup) failure with metallosis and abdominal pseudotumour formation. The patient had a ce…