Susanne Hartmann
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View article: Ascarids and One Health: Emerging Challenges in Sustainable Control
Ascarids and One Health: Emerging Challenges in Sustainable Control Open
Ascarid infections, caused by Ascaris lumbricoides (humans), Ascaris suum (domestic pigs and wild boars), Parascaris spp. (equids), Ascaridia galli (poultry) and Toxocara spp. (dogs, foxes, and cats), remain a significant global challenge,…
View article: Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adult Ascaris excretory/secretory antigens in pigs
Larval ascariasis elicits a prominent IgA and IgG1/2 antibody response to adult Ascaris excretory/secretory antigens in pigs Open
Roundworm infections result in morbidity, causing significant health and economic concerns in humans and pigs, respectively. We investigated the humoral responses of Ascaris suum infected pigs before and after transition from larval to adu…
View article: Liver-draining portal lymph node responds to enteric nematode infection by generating highly parasite-specific follicular T helper and B cell responses
Liver-draining portal lymph node responds to enteric nematode infection by generating highly parasite-specific follicular T helper and B cell responses Open
Introduction While research on the gut-liver axis in non-communicable liver diseases has expanded exponentially, few studies have investigated the liver-gut relationship in the context of gastrointestinal nematode infections. This study ai…
View article: Differential resistance to nematode infection is associated with the genotype- and age-dependent pace of intestinal T cell homing
Differential resistance to nematode infection is associated with the genotype- and age-dependent pace of intestinal T cell homing Open
The resistance of inbred mice to nematode infections varies depending on the extent of protective Th2 responses. Here, we compared two mouse lines differing in resistance to infection with the enteric nematode Heligmosomoides polygyrus bak…
View article: Two-photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure
Two-photon NAD(P)H-FLIM reveals unperturbed energy metabolism of Ascaris suum larvae, in contrast to host macrophages upon artemisinin derivatives exposure Open
View article: Research PaperAnimal welfare investigation concerning separation tool to perform a bite release based on the example of military service dogs in the German Military
Research PaperAnimal welfare investigation concerning separation tool to perform a bite release based on the example of military service dogs in the German Military Open
View article: Infliximab for treatment of corticosteroid-refractory immune checkpoint inhibitor-induced hepatitis in patients with melanoma
Infliximab for treatment of corticosteroid-refractory immune checkpoint inhibitor-induced hepatitis in patients with melanoma Open
View article: Aggregation of adult parasitic nematodes in sex-mixed groups analysed by transient anomalous diffusion formalism
Aggregation of adult parasitic nematodes in sex-mixed groups analysed by transient anomalous diffusion formalism Open
Intestinal parasitic worms are widespread throughout the world, causing chronic infections in humans and animals. However, very little is known about the locomotion of the worms in the host gut. We studied the movement of Heligmosomoides b…
View article: Differential resistance to nematode infection is associated with the genotype- and age- dependent pace of intestinal T cell homing
Differential resistance to nematode infection is associated with the genotype- and age- dependent pace of intestinal T cell homing Open
The resistance of inbred mice to nematode infections varies depending on the extent of protective Th2 responses. Here, we compared two mouse lines differing in resistance to infection with the enteric nematode Heligmosomoides polygyrus bak…
View article: Two-Photon NAD(P)H-FLIM reveals unperturbed energy metabolism of<i>Ascaris suum</i>larvae, in contrast to host macrophages upon artemisinin derivatives exposure
Two-Photon NAD(P)H-FLIM reveals unperturbed energy metabolism of<i>Ascaris suum</i>larvae, in contrast to host macrophages upon artemisinin derivatives exposure Open
Soil-transmitted helminths (STH) are widespread, with Ascaris lumbricoides infecting millions globally. Malaria and STH co-infections are common in co-endemic regions. Artemisinin derivatives (ARTs)—artesunate, artemether, and dihydroartem…
View article: Concurrent <i>Ascaris</i> infection modulates host immunity resulting in impaired control of <i>Salmonella</i> infection in pigs
Concurrent <i>Ascaris</i> infection modulates host immunity resulting in impaired control of <i>Salmonella</i> infection in pigs Open
Ascaris is one of the most widespread helminth infections, leading to chronic morbidity in humans and considerable economic losses in pig farming. In addition, pigs are an important reservoir for the zoonotic salmonellosis , where pigs can…
View article: Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection
Th2-biased immune responses to body migrating Ascaris larvae in primary infection are associated with pathology but not protection Open
View article: Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs
Acute Ascaris infection impairs the effector functions of natural killer cells in single and Salmonella co-infected pigs Open
Natural killer (NK) cells play a key role in defense against Salmonella infections during the early phase of infection. Our previous work showed that the excretory/secretory products of Ascaris suum repressed NK activity in vitro. Here, we…
View article: Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings
Evaluation of copromicroscopy, multiplex-qPCR and antibody serology for monitoring of human ascariasis in endemic settings Open
Background The standard diagnosis of Ascaris lumbricoides and other soil-transmitted helminth (STH) infections relies on the detection of worm eggs by copromicroscopy. However, this method is dependent on worm patency and shows only limite…
View article: Ascaris suum infection in juvenile pigs elicits a local Th2 response in a setting of ongoing Th1 expansion
Ascaris suum infection in juvenile pigs elicits a local Th2 response in a setting of ongoing Th1 expansion Open
Ascaris spp. undergo extensive migration within the body before establishing patent infections in the small intestinal tract of humans and pigs. However, whether larval migration is critical for inducing efficient type 2 responses remains …
View article: Anomalous diffusion analysis reveals cooperative locomotion of adult parasitic nematodes in sex-mixed groups
Anomalous diffusion analysis reveals cooperative locomotion of adult parasitic nematodes in sex-mixed groups Open
Parasitic worms are widespread throughout the world and causing agents of chronic infections in humans and animals. The majority of these pathogens parasitize the gut of the infected hosts, however very little is known about the locomotion…
View article: Concurrent<i>Ascaris</i>infection modulates host immunity resulting in impaired control of<i>Salmonella</i>infection in pigs
Concurrent<i>Ascaris</i>infection modulates host immunity resulting in impaired control of<i>Salmonella</i>infection in pigs Open
Ascaris is one of the most widespread helminth infections of humans and pigs, leading to chronic morbidity in humans and considerable economic losses in pig farming. Additionally, pigs are an important reservoir for the zoonotic bacterial …
View article: Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids
Getting around the roundworms: Identifying knowledge gaps and research priorities for the ascarids Open
View article: Quantifying metabolic activity of Ascaris suum L3 using resazurin reduction
Quantifying metabolic activity of Ascaris suum L3 using resazurin reduction Open
View article: Infection with soil-transmitted helminths and their impact on coinfections
Infection with soil-transmitted helminths and their impact on coinfections Open
The most important soil-transmitted helminths (STHs) affecting humans are roundworms, whipworms, and hookworms, with a large proportion of the world’s population infected with one or more of these intestinal parasites. On top of that, conc…
View article: Immunization with excretory‐secretory molecules of intestinal nematodes induces antigen‐specific protective memory Th2 cell responses
Immunization with excretory‐secretory molecules of intestinal nematodes induces antigen‐specific protective memory Th2 cell responses Open
Parasitic nematodes infect more than 1 billion people in the global south. The development of effective antihelminthic vaccines is a crucial tool for their future elimination. Protective immune responses to nematodes depend on Gata3 + Th2 …
View article: Guts within guts: the microbiome of the intestinal helminth parasite Ascaris suum is derived but distinct from its host
Guts within guts: the microbiome of the intestinal helminth parasite Ascaris suum is derived but distinct from its host Open
View article: Dietary fiber and its role in performance, welfare, and health of pigs
Dietary fiber and its role in performance, welfare, and health of pigs Open
Dietary fiber (DF) is receiving increasing attention, and its importance in pig nutrition is now acknowledged. Although DF for pigs was frowned upon for a long time because of reductions in energy intake and digestibility of other nutrient…
View article: Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation
Th2 and metabolic responses to nematodes are independent of prolonged host microbiota abrogation Open
Antibiotic treatment can lead to elimination of both pathogenic bacteria and beneficial commensals, as well as to altered host immune responses. Here, we investigated the influence of prolonged antibiotic treatment (Abx) on effector, memor…
View article: Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets
Ascaris suum excretory/secretory products differentially modulate porcine dendritic cell subsets Open
Helminths produce excretory/secretory products (E/S) which can modulate the immune responses of their hosts. Dendritic cells (DC) are essential for initiating the host T cell response and are thus potential targets for modulation by helmin…
View article: Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection
Age-dependent rise in IFN-γ competence undermines effective type 2 responses to nematode infection Open
View article: NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host
NAD(P)H fluorescence lifetime imaging of live intestinal nematodes reveals metabolic crosstalk between parasite and host Open
Infections with intestinal nematodes have an equivocal impact: they represent a burden for human health and animal husbandry, but, at the same time, may ameliorate auto-immune diseases due to the immunomodulatory effect of the parasites. T…
View article: The Host Peritoneal Cavity Harbors Prominent Memory Th2 and Early Recall Responses to an Intestinal Nematode
The Host Peritoneal Cavity Harbors Prominent Memory Th2 and Early Recall Responses to an Intestinal Nematode Open
Intestinal parasitic nematodes affect a quarter of the world’s population, typically eliciting prominent effector Th2-driven host immune responses. As not all infected hosts develop protection against reinfection, our current understanding…
View article: A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease
A Helminth-Derived Chitinase Structurally Similar to Mammalian Chitinase Displays Immunomodulatory Properties in Inflammatory Lung Disease Open
Immunomodulation of airway hyperreactivity by excretory-secretory (ES) products of the first larval stage (L1) of the gastrointestinal nematode Trichuris suis is reported by us and others. Here, we aimed to identify the proteins accounting…
View article: NAD(P)H Fluorescence Lifetime Imaging of Live Intestinal Nematodes Reveals Metabolic Crosstalk Between Parasite and Host
NAD(P)H Fluorescence Lifetime Imaging of Live Intestinal Nematodes Reveals Metabolic Crosstalk Between Parasite and Host Open
Infections with intestinal nematodes have an ambivalent impact: they represent a burden for human health and animal husbandry, but, at the same time, may ameliorate auto-immune diseases due to the immunomodulatory effect of the parasites. …