Susanne Keipert
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View article: IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat
IF1 is a cold-regulated switch of ATP synthase to support thermogenesis in brown fat Open
While mechanisms controlling mitochondrial uncoupling protein-1 (UCP1) expression and function in thermogenic adipocytes play a pivotal role in non-shivering thermogenesis (NST), it remains unclear whether F 1 F o -ATP synthase function is…
View article: Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21
Hyperphagia of female UCP1-deficient mice blunts anti-obesity effects of FGF21 Open
Increasing energy expenditure through uncoupling protein 1 (UCP1) activity in thermogenic adipose tissue is widely investigated to correct diet-induced obesity (DIO). Paradoxically, UCP1-deficient male mice are resistant to DIO at room tem…
View article: Protection from alcohol intoxication: Must be FGF21 to enter
Protection from alcohol intoxication: Must be FGF21 to enter Open
Fibroblast growth factor 21 (FGF21) is generally known as a stress-induced metabolic regulator with enormous therapeutic potential to treat metabolic diseases, but a more specific role of FGF21 concerns physiological handling of alcohol in…
View article: Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue
Obesity-resistance of UCP1-deficient mice associates with sustained FGF21 sensitivity in inguinal adipose tissue Open
Metabolic diseases represent the major health burden of our modern society. With the need of novel therapeutic approaches, fibroblast growth factor 21 (FGF21) is a promising target, based on metabolic improvements upon FGF21 administration…
View article: Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis
Activating ligands of Uncoupling protein 1 identified by rapid membrane protein thermostability shift analysis Open
Uncoupling protein 1 (UCP1) catalyzes mitochondrial proton leak in brown adipose tissue for heat production, and may combat metabolic disease if activated in humans. During the adrenergic stimulation of brown adipocytes, free fatty acids g…
View article: Author Correction: Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
Author Correction: Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice Open
A Correction to this paper has been published: https://doi.org/10.1038/s41467-021-22119-x
View article: Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice
Identification and characterization of distinct brown adipocyte subtypes in C57BL/6J mice Open
Brown adipose tissue (BAT) plays an important role in the regulation of body weight and glucose homeostasis. Although increasing evidence supports white adipose tissue heterogeneity, little is known about heterogeneity within murine BAT. R…
View article: Identification and characterization of distinct murine brown adipocyte lineages
Identification and characterization of distinct murine brown adipocyte lineages Open
Brown adipose tissue (BAT) plays an important role in the regulation of body weight and glucose homeostasis. While increasing evidence supports white adipose tissue heterogeneity, little is known about heterogeneity within murine BAT. Usin…
View article: Adapting to the Cold: A Role for Endogenous Fibroblast Growth Factor 21 in Thermoregulation?
Adapting to the Cold: A Role for Endogenous Fibroblast Growth Factor 21 in Thermoregulation? Open
Fibroblast growth factor 21 (FGF21) is in biomedical focus as a treatment option for metabolic diseases, given that administration improves metabolism in mice and humans. The metabolic effects of exogenous FGF21 administration are well-cha…
View article: The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation
The scaffold protein p62 regulates adaptive thermogenesis through ATF2 nuclear target activation Open
During β-adrenergic stimulation of brown adipose tissue (BAT), p38 phosphorylates the activating transcription factor 2 (ATF2) which then translocates to the nucleus to activate the expression of Ucp1 and Pgc-1α . The mechanisms underlying…
View article: Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress
Muscle‐derived GDF15 drives diurnal anorexia and systemic metabolic remodeling during mitochondrial stress Open
Mitochondrial dysfunction promotes metabolic stress responses in a cell-autonomous as well as organismal manner. The wasting hormone growth differentiation factor 15 (GDF15) is recognized as a biomarker of mitochondrial disorders, but its …
View article: Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice
Endogenous FGF21-signaling controls paradoxical obesity resistance of UCP1-deficient mice Open
Uncoupling protein 1 (UCP1) executes thermogenesis in brown adipose tissue, which is a major focus of human obesity research. Although the UCP1-knockout (UCP1 KO) mouse represents the most frequently applied animal model to judge the anti-…
View article: Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles
Prediction of Adipose Browning Capacity by Systematic Integration of Transcriptional Profiles Open
Activation and recruitment of thermogenic cells in human white adipose tissues ("browning") can counteract obesity and associated metabolic disorders. However, quantifying the effects of therapeutic interventions on browning remains enigma…
View article: Mitochondria are physiologically maintained at close to 50 °C
Mitochondria are physiologically maintained at close to 50 °C Open
In endothermic species, heat released as a product of metabolism ensures stable internal temperature throughout the organism, despite varying environmental conditions. Mitochondria are major actors in this thermogenic process. Part of the …
View article: Erratum. Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66:1247–1257
Erratum. Direct Substrate Delivery Into Mitochondrial Fission–Deficient Pancreatic Islets Rescues Insulin Secretion. Diabetes 2017;66:1247–1257 Open
In the article listed above, the x -axis labeling in Fig. 6 C was mistakenly included twice during figure preparation; the labeling was …
View article: Mitochondria are physiologically maintained at close to 50 °C
Mitochondria are physiologically maintained at close to 50 °C Open
In endothermic species, heat released as a product of metabolism ensures stable internal temperature throughout the organism, despite varying environmental conditions. Mitochondria are major actors in this thermogenic process. Part of the …