Susanne Muschert
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View article: Disease‐Adaptive Drug Delivery to the Inflamed Intestinal Mucosa Using Poly(Lactic‐<i>Co</i>‐Glycolic Acid)‐cyclodextrin Hybrid Nanocarriers
Disease‐Adaptive Drug Delivery to the Inflamed Intestinal Mucosa Using Poly(Lactic‐<i>Co</i>‐Glycolic Acid)‐cyclodextrin Hybrid Nanocarriers Open
Fluctuating severity of symptoms is a common hallmark of many inflammatory disorders, including inflammatory bowel disease (IBD). Addressing the pH changes during active and resting phases in IBD‐affected tissue, a disease‐adaptive nanocar…
View article: Impact of Hot-Melt Extrusion on Glibenclamide’s Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices
Impact of Hot-Melt Extrusion on Glibenclamide’s Physical and Chemical States and Dissolution Behavior: Case Studies with Three Polymer Blend Matrices Open
This research work dives into the complexity of hot-melt extrusion (HME) and its influence on drug stability, focusing on solid dispersions containing 30% of glibenclamide and three 50:50 polymer blends. The polymers used in the study are …
View article: Nanoemulsion Loaded with Clotrimazole Based on Rapeseed Oil for Potential Vaginal Application—Development, Initial Assessment, and Pilot Release Studies
Nanoemulsion Loaded with Clotrimazole Based on Rapeseed Oil for Potential Vaginal Application—Development, Initial Assessment, and Pilot Release Studies Open
Vaginal candidiasis (VC) is an emerging global hardly treated health issue affecting millions of women worldwide. In this study, the nanoemulsion consisting of clotrimazole (CLT), rapeseed oil, Pluronic F-68, Span 80, PEG 200, and lactic a…
View article: Drug-Release Mechanisms Elucidated by Imaging Techniques: Visualizing the Invisible!
Drug-Release Mechanisms Elucidated by Imaging Techniques: Visualizing the Invisible! Open
Imaging techniques such as Raman spectroscopy, electron microscopy, laser scanning confocal microscopy, atomic force microscopy, tomography, magnetic resonance imaging, and terahertz are powerful tools to elucidate drug-release mechanisms …
View article: Towards a Better Understanding of Verapamil Release from Kollicoat SR:IR Coated Pellets Using Non-Invasive Analytical Tools
Towards a Better Understanding of Verapamil Release from Kollicoat SR:IR Coated Pellets Using Non-Invasive Analytical Tools Open
The aim of this study was to gain deeper insight into the mass transport mechanisms controlling drug release from polymer-coated pellets using non-invasive analytical tools. Pellet starter cores loaded with verapamil HCl (10% loading, 45% …